Term
| The theory of ADHD malfunction is that the _ inhibiton is deicient wherre? |
|
Definition
response
prefrotnal cortex |
|
|
Term
| dysregulaiton of _ has also been a theorry of ADHD malfunctoin |
|
Definition
|
|
Term
| The ADHD treatments target what 2 substances, and these help with what-2 |
|
Definition
NE, DA
executive functioning, arousal |
|
|
Term
| what has expanded in primates and humans? |
|
Definition
|
|
Term
| what is the function of the prefrontal cortex-2 |
|
Definition
| decision mkaing and behvaior |
|
|
Term
| what are the parts of the prefrontal cortex affected in ADHD-4 |
|
Definition
dorsal anterior cingulate cortex
dosolateal prefrontal cortex
prefrotnal motor cortex
obitofrontal cortex |
|
|
Term
what is the function of the dorsal anterrio cingulate cortex?
what is a characterstic that shows a problem with this? |
|
Definition
slective attention
cant focus attenion, lose things, forget things |
|
|
Term
| what is the function of dosrolateral prefrontal cortex-3 |
|
Definition
| sustained attention, probelm solving, executive function |
|
|
Term
| what does the prefrontal motor cortex control |
|
Definition
|
|
Term
| what does the orbitofrontal cortex control |
|
Definition
|
|
Term
| damage to _ causes symptoms like-3 |
|
Definition
prefrontal motor
like fidgeting, have trouble being quiet or still |
|
|
Term
| damage to _ causes symtpoms like-2 |
|
Definition
orbital frontal cortex
talking excessive, blurting out |
|
|
Term
| which med is the cure for ADHD? |
|
Definition
|
|
Term
ppl with hypoarousal during the day expereience what-3
what symtpoms is linked wiht hypofunciton of orbital frontal cortex |
|
Definition
inattention, sleepy, impulsivity
impulsivity |
|
|
Term
| can hyperactivity arise from a person fighting their hypoarousal state? |
|
Definition
|
|
Term
| hypoaorusal is asoc with low firing of what 2 things- |
|
Definition
|
|
Term
| how do you treat hypoarousal ? |
|
Definition
| increase DA and NE in prefrontal cortex |
|
|
Term
| hyperarousal is associtated with chronic- |
|
Definition
|
|
Term
hyperarousal means the _ is out of tune?
this means there is too much firing of? |
|
Definition
|
|
Term
| how do you decrease hyperarousal? |
|
Definition
|
|
Term
| what med blocks NE continously? |
|
Definition
|
|
Term
| what med acts continously at 2A adrenergic recetpors to block DA/NE |
|
Definition
|
|
Term
| how do stimulants increase Ne and DA?-2 |
|
Definition
block NE trnasporter
block DA trnasporter |
|
|
Term
| what are the stimulants-2 |
|
Definition
amphetamine
methylphenidate |
|
|
Term
| what are other names for amphetamine |
|
Definition
|
|
Term
| what are other names for methylphenidate-2 |
|
Definition
|
|
Term
| high doses of stimulants can cause actions seen in- |
|
Definition
|
|
Term
| thereaputic improvement depedns on what |
|
Definition
| how fast and how long the stimulants occupy the trnasporters |
|
|
Term
| the best thing for stimulant therapy is for a _ onset with _ drug levels, and then _ action |
|
Definition
| slow, substantial, long duraiton of |
|
|
Term
| pulsatile stimulants cause what |
|
Definition
| rapid increases in NE and SA and abuse |
|
|
Term
| look at slide 46 to clarify on stimulants |
|
Definition
|
|
Term
immediate release forms of stimulants has to be taken how many tiems per day?
why |
|
Definition
|
|
Term
| once daily stimulants provide how many hours of symtpoms control?q |
|
Definition
|
|
Term
| Daytrana is what kind of formulation |
|
Definition
|
|
Term
| Concerta is what kind of formulaiton |
|
Definition
| osmotic controlled release |
|
|
Term
| what are rare side effects of stimulatns-3 |
|
Definition
height deficit
cardiac
psychiatric |
|
|
Term
| what are some common side effects fo stimulants-3 |
|
Definition
stomach ache
headhache
irritable |
|
|
Term
| does taking stimulants increase risk for substance abus? |
|
Definition
| no, it can lower it if taken correctly |
|
|
Term
inhibitng NET can increase NE AND DA where?
where can it not do this? why? |
|
Definition
preforntal cortex
nucelus accumdens, bc not a lot of NET there |
|
|
Term
what medicine is best for decrease arousal-
due to this, these drugs have what potential for abuse |
|
Definition
selective sNRIs in the prefrontal cortex
but wont affect the accumbens;
none |
|
|
Term
|
Definition
|
|
Term
| what is the MOA of atomoxetine |
|
Definition
|
|
Term
| is atomoxetine a controlled substance? |
|
Definition
|
|
Term
| How does the onset of action for atomoxetine compare to stimulants? |
|
Definition
| slower 2-4 weeks compared to 1 hr |
|
|
Term
| side effects of atomoxetine-3 |
|
Definition
| anorexia, fatigue, sedation |
|
|
Term
| why are alpha 2 adrenergic recptors a good target for ADHD? |
|
Definition
| present in prefrontal but not accumbens |
|
|
Term
| the alpha 2 aderenergic receptors are responsible or what symtpoms of ADHD? |
|
Definition
| inattention, hyperactive AND impulsivity |
|
|
Term
| what is the MOA of clonidine |
|
Definition
| alpha 2 non selective agonist |
|
|
Term
| what is the MOA of Guanfacine? |
|
Definition
| alpha 2A selective agonist |
|
|
Term
| what is diff between clonidine and guafacine |
|
Definition
| guanfacine has less side effects and long half life |
|
|
Term
| the noradreenrigc agents are more less effective than other ADHD drugs? |
|
Definition
|
|
Term
| what are noradrenergic drugs adjuncts for? |
|
Definition
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|
Term
|
Definition
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