Term
| what is unique about nitrates? |
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Definition
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Term
| when metabolized what do nitrates release |
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Definition
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Term
| no vasodilation occurs by decreasing intracellular- and dephosphoryltaitng _ |
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Definition
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Term
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Definition
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Term
low doses of nitrates dilate veins or arteries?
what is the overall BP reduction? |
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Definition
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Term
| high doses of nitrates can cause? |
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Definition
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Term
| hgih doses of nitrates cause venous _ adn decreased aretery _ |
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Definition
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Term
| to work on coronary blood flow what dose of nitratres is needed? |
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Definition
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Term
low to mod dose of nitrates:
dilate the _
dont impair
decreases _ |
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Definition
epicardial vessels
autoregulation in small vessels
BP |
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Term
| if nitrates dilate these vein it can imporve coronary microcirculation |
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Definition
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Term
| Nitrates can increase blow flow to the _ |
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Definition
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Term
| what is the primary antianginal affect of nitrates? -2 |
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Definition
decrease venous return
decrease O2 demand |
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Term
| what does NO do to plateltes? |
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Definition
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Term
| repeated high doses of nitrates can lead to- |
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Definition
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Term
Most common ADE of nitrates?
what are others-3 |
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Definition
headache;
rash, dizziness, orthostatic hypotension |
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Term
nitrate + PDE5 inhibitor causes severe-
why? |
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Definition
hypotension
inhibit the degredation of cGMP |
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Term
| which isosorbide can be oral or sublingual |
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Definition
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Term
| sublingual NTG has faster_ but less _ than oral |
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Definition
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Term
| dose for isosorbide mononitrate |
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Definition
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Term
| dose for isosobide dinitrate |
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Definition
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Term
dose for NTG Sublingual
for oral |
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Definition
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Term
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Definition
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Term
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Definition
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Term
| ALL nitrates have a large what- |
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Definition
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Term
| all nitrates but _ have short half life and fast cleareance -2 |
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Definition
isorbide mononitratre
NTG Patch |
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Term
highest conc of nitrate seen thru what admin?
lowest seen thru? |
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Definition
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Term
| sublingual NTG used for- 2 |
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Definition
angial attack
before exercise |
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Term
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Definition
| clinic for better control |
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Term
| what admin of NTG is used for long term?- 3 |
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Definition
| chewable, oral, trnasdermal |
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Term
| Beta blockers for these disease target what receptor? |
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Definition
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Term
| blocking B1 recpotr decreases what? |
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Definition
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Term
| in what type of disease does ebta blocker imrpove mortality |
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Definition
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Term
DHP-CCBs cause what to O2?
how? |
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Definition
increase in supply
vasodilation, decrease PR |
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Term
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Definition
1)smooth msucle relaxation (vasodilate)
2) decrease platelet activation |
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Term
| how does dipyridamole cause vasodilation? |
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Definition
| inhibits PDE- increase in cGMP- then works like NO |
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Term
| how does dipyridamole cause decrease in platelet activaiton |
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Definition
| inhibits adenosine uptake- more on platelet surface->A2 recptor stimulated-> incr cAMP |
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