Term
|
Definition
| Movement of drug from the blood to its site of action or storage |
|
|
Term
T/F
You do not have control over where the drug goes |
|
Definition
|
|
Term
T/F
Metabolism will cause drug to move back into the blood |
|
Definition
TRUE
met. causes a decrease in concentration in the blood and quilibrium will shift |
|
|
Term
Distribution Pattern
A) [drug] in blood = [drug] in tissue
B) [drug] higher in tissue than blood
C) [drug] higher in blood than tissue |
|
Definition
A) Total body water
B) Sequestered in Tissue
C) Primarily in the blood |
|
|
Term
Definition
Volume of Distribution |
|
Definition
| Volume at which the drug will be uniformly diluted to account for plasma concentration |
|
|
Term
|
Definition
Administer drug, Collect blood samples and measure [] @ different times, extrapolate to time zero
Vd= dose/C0 |
|
|
Term
What factors affect drug distribution?
(7) |
|
Definition
Lipophilicity
Acid/base ionization
molecular weight
blood flow
tissue permeability
plasma protein binding
active transporters |
|
|
Term
Why can anestetics penetrate the BBB so easily?
|
|
Definition
| The are very lipid soluble |
|
|
Term
| How do bran efflux pumps work? |
|
Definition
| Pump molecules from the brain and into the blood |
|
|
Term
Does the brain need influx pumps?
Why or why not? |
|
Definition
YES
almost all cells make proteins (amino acids) and you need to get these into the brain |
|
|
Term
What is the role of fenestrations?
Does the brain have these, why or why not? |
|
Definition
Fenestrations allow for the bulk flow of water and small lipid soluble molecules
The brain has TIGHT JUNCTIONS to prevent bulk flow |
|
|
Term
T/F
a drug that's a substrate for Pgp will NOT enter the brain |
|
Definition
|
|
Term
T/F
protein binding slows distribution of drug |
|
Definition
|
|
Term
How does liver damage relate to protein binding?
|
|
Definition
| Liver makes majoy proteins and less proteins mean less protein binding |
|
|
Term
What are the major plasma proteins?
(3) |
|
Definition
Albumin
alpa1-acid glycoprotein
lipoproteins |
|
|
Term
T/F
Bound drugs are able to move into the interstitium |
|
Definition
FALSE
Unbound drugs move to interstitium |
|
|
Term
T/F
Warfarin can be 100% bound |
|
Definition
|
|
Term
What types of drugs can cross the placenta?
which cant? |
|
Definition
CAN- lipophilic
CANT- polar |
|
|
Term
| What does it mean to be a drug reservoir? |
|
Definition
| prolong duration time in the body |
|
|
Term
What are some drug reserviors?
(5) |
|
Definition
Plasma proteins
Cells
Adipose
Bone
Teeth |
|
|
