Term
Definition:
A)Pharmacodynamics
&
B) Pharmacokinetics |
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Definition
A) Effect of Drug on the body
B) Effect of Body on the drug |
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Term
T/F
ADME occurs in sequential order |
|
Definition
False
all occurring simultaneously |
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Term
Passive Diffusion
A) energy?
B) up or down concentration gradient
C) Carriers? |
|
Definition
A) No energy required, uses kinetic energy
B) Down concentration gradient
C) No carriers |
|
|
Term
T/F
Increasing C1 results in greater absorption |
|
Definition
TRUE
increase in C1 creates a larger concentration gradient, and therefore an increase in absorption
|
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Term
| Passive Diffusion excludes_____and allows for _____ substances (polarity & lipophilicty) |
|
Definition
excludes Polar substances
allows lipophilic substances |
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Term
Definition and Equation
Fick's Law |
|
Definition
transport rate or flux across a membrane
(C1-C2) x area x perm. coefficient
thickness |
|
|
Term
T/F
Permeability Coefficient is related to lipophilicty |
|
Definition
TRUE
its the ability of drug molecules to move through a membrane |
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Term
| For Passive Diffusion, does the presence of a different drug affect the transport rate of a drug? |
|
Definition
| No, molecules move independently of one another |
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|
Term
Primary or Secondary Active? & ATP directly dependent?
A) Pgp
B) Solute Carrier proteins
C)PepT1
D)ATP binding Cassette proteins |
|
Definition
A) Primary yes
B) Secondary no
C) Secondary no
D) Primary yes |
|
|
Term
Active Transport
A) up/down concentration gradient
B) Carrier?
C) enegery?
|
|
Definition
A) against concentration gradient
B) Yes
C) ATP yes |
|
|
Term
Definition
A) Primary Active Transport
B) Secondary Active Transport
|
|
Definition
A) transporter itself has to extend energy
B) energy dependent but not directly, coupled with something else moving across the membrane |
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Term
Kinetics
A) V?
B) Vmax
C)Km |
|
Definition
A) transport rate at substrate concentration C
B) maximum transport rate
C) substrate concentration at which the transport rate is 1/2 Vmax (dissociation constant) |
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Term
MATCH
A) Competitive Inhibitor 1) Altered Translocation
B) Substrate 2) Altered binding
C) Non-competitive Inhibitor 3) Normal Transport |
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Definition
A) Competitive Inhibitor=2) Altered binding
B) Substrate=3) Normal Transport
C) Non-competitive Inhibitor=1) Altered Translocation
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Term
Facilitated Diffusion
A) carrier?
B) energy?
C) up/down concentration gradient |
|
Definition
A) Yes carrier
B) no energy
C) down con. gradient |
|
|
Term
| What is endocytosis? What types of molecules are involved? |
|
Definition
cell membrane engulfs molecules
Large...too large for Active Transport |
|
|
Term
| What is bulk flow and what is it dependent on? |
|
Definition
| Movement between cells and it depends on the tisse |
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