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Exam 2
Transport
16
Pharmacology
Professional
10/13/2010

Additional Pharmacology Flashcards

 


 

Cards

Term

Definition:

A)Pharmacodynamics
&

B) Pharmacokinetics

Definition

A) Effect of Drug on the body

B) Effect of Body on the drug

Term

T/F

ADME occurs in sequential order

Definition

False

all occurring simultaneously

Term

Passive Diffusion

A) energy?

B) up or down concentration gradient

C) Carriers?

Definition

A) No energy required, uses kinetic energy

B) Down concentration gradient

C) No carriers

Term

T/F

Increasing C1 results in greater absorption

Definition

TRUE

increase in C1 creates a larger concentration gradient, and therefore an increase in absorption

 

Term
Passive Diffusion excludes_____and allows for _____ substances (polarity & lipophilicty)
Definition

excludes Polar substances

allows lipophilic substances

Term

Definition and Equation

Fick's Law

Definition

transport rate or flux across a membrane

(C1-C2) x    area x perm. coefficient

        thickness

Term

T/F

Permeability Coefficient is related to lipophilicty

Definition

TRUE

its the ability of drug molecules to move through a membrane

Term
For Passive Diffusion, does the presence of a different drug affect the transport rate of a drug?
Definition
No, molecules move independently of one another
Term

Primary or Secondary Active? & ATP directly dependent?

A) Pgp

B) Solute Carrier proteins

C)PepT1

D)ATP binding Cassette proteins

Definition

A) Primary yes

B) Secondary no

C) Secondary no

D) Primary yes

Term

Active Transport

A) up/down concentration gradient

B) Carrier?

C) enegery?

 

Definition

A) against concentration gradient

B) Yes

C) ATP yes

Term

Definition

A) Primary Active Transport

B) Secondary Active Transport

 

Definition

A) transporter itself has to extend energy

B) energy dependent but not directly, coupled with something else moving across the membrane

Term

Kinetics

A) V?

B) Vmax

C)Km

Definition

A) transport rate at substrate concentration C

B) maximum transport rate

C) substrate concentration at which the transport rate is 1/2 Vmax (dissociation constant)

Term

MATCH

A) Competitive Inhibitor        1) Altered Translocation

B) Substrate                      2) Altered binding

C) Non-competitive Inhibitor   3) Normal Transport

Definition

 

A) Competitive Inhibitor=2) Altered binding

 

B) Substrate=3) Normal Transport

 

C) Non-competitive Inhibitor=1) Altered Translocation

 

Term

Facilitated Diffusion

A) carrier?

B) energy?

C) up/down concentration gradient

Definition

A) Yes carrier

B) no energy

C) down con. gradient

Term
What is endocytosis? What types of molecules are involved?
Definition

cell membrane engulfs molecules

Large...too large for Active Transport

Term
What is bulk flow and what is it dependent on?
Definition
Movement between cells and it depends on the tisse
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