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Exam 2 Cardio 2
Drugs
121
Pharmacology
Graduate
03/14/2011
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Term
Tolterodine - Overactive Bladder
 Definition
(Detrol)
Term
Oxybutynin - Overactive Bladder
 Definition
(Ditropan)
Term
Darifenacin - Overactive Bladder
 Definition
(Enablex)
Term
Solifenacin - Overactive Bladder
 Definition
(Vesicare)
Term
Trospium- Overactive Bladder
 Definition
(Sanctura)
Term
Fesoterodine - Overactive Bladder
 Definition
(Toviaz)
Term
Flavoxate - Overactive Bladder
 Definition
(Urispas)
Term
Propantheline - GI/IBS/Pre-Op
 Definition
(ProBanthine)
Term
Dicyclomine - GI/IBS/Pre-Op
 Definition
(Bentyl)
Term
Glycopyrrolate - GI/IBS/Pre-Op
 Definition
(Robinul)
Term
Tropicamide -mydriasis/cylcoplegia
 Definition
(Mydriacyl)
Term
Tropicamide/Hydroxyamphetamine -mydriasis/cylcoplegia
 Definition
(Paremyd)
Term
Cyclopentolate -mydriasis/cylcoplegia
 Definition
(Cyclogyl)
Term
Pancuronium- Non depolarizing blocking agent
 Definition
(Pavulon)
Term
Succinylcholine - depolarizing blocking agent
 Definition
(Anectine)
Term
Norepinephrine - Direct acting NS
 Definition
(Levophed) α1, α2, β1
Term
Epinephrine - Direct acting NS
 Definition
(Adrenalin) α1, α2, β1, β2
Term
Isoproterenol - Direct acting NS
 Definition
(Isuprel) β1, β2
Term
Dobutamine - Direct acting NS
 Definition
(Dobutrex) β1, some β2
Term
Fenoldopam - Direct acting NS
 Definition
(Corlopam) D1
Term
Carvedilol - antioxidant (non class effect) decrease apoptosis
 Definition
Coreg β1, β2, possibly α1
Term
Captopril -1st ACEi; caused blood dyscrasia; reduce dose made more effective
 Definition
Capoten
Term
Enalapril - ACEi
 Definition
Vasotec (Enalaprilat - Vasotec I.V.)
Term
Lisinopril - ACEi
 Definition
Prinivil, Zestril
Term
Ramipril - ACEi
 Definition
Altace
Term
Quinapril - ACEi
 Definition
Accupril
Term
Trandolapril - ACEi
 Definition
Mavik
Term
Fosinopril - ACEi
 Definition
Monopril
Term
Benazepril - ACEi
 Definition
Lotensin
Term
Moexipril - ACEi
 Definition
Univasc
Term
Perindopril - ACEi
 Definition
Aceon
Term
Losartan - ARB prodrug weak; active metabolite
uricosuric
reversible
 Definition
Cozaar
Term
Valsartan - ARB
 Definition
Diovan
Term
Irbesartan - ARB
 Definition
Avapro
Term
Candesartan - ARB prodrug -activated in intestine not kidney
irreversible
 Definition
Atacand
Term
Telmisartan - ARB
 Definition
Micardis
Term
Eprosartan - ARB
 Definition
Teveten
Term
Olmesartan - ARB prodrug
activated in intestine not kidney
 Definition
Benicar
Term
Aliskiren - NOT used for CHF
Renin inhibitor
 Definition
Tekturna
Term
Nesiritide - atrial natriurectic factor
recombinate form of B-NF
dilatione, used for acute decompensated CHF, more cGMP
 Definition
Natrecor
Term
Chlorothiazide -thiazide
high dose needed for same efficacy
 Definition
Diuril
Term
Hydrochlorothiazide (HCTZ) -thiazide
low dose needed for same efficacy
 Definition
Hydrodiuril, Esidrix, Oretic
Term
Methyclothiazide -thiazide
 Definition
Enduron
Term
Polythiazide -thiazide
 Definition
Renese
Term
Chlorthalidone -thiazide
 Definition
Hygroton
Term
Metolazone -thiazide
 Definition
Zaroxolyn
Term
Indapamide -thiazide
 Definition
Lozol
Term
Furosemide -loop diuretic
 Definition
Lasix
Term
Ethacrynic acid -loop diuretic
 Definition
Edecrin
Term
Bumetanide -loop diuretic
 Definition
Bumex
Term
Torsemide -loop diuretic
 Definition
Demadex
Term
Triamterene - K sparing diuretic
bind to Na channel
no effect on aldosterone
 Definition
Dyrenium
Term
Amiloride - K sparing diuretic
 Definition
Midamor
Term
Spironolactone - K sparing diuretic
bind to MR receptor
reduce effect on aldosterone
 Definition
Aldactone
Term
Eplerenone - K sparing diuretic
similar to spironolactone but no hormone effects
 Definition
Inspra
Term
Mannitol - osmotic diuretic
 Definition
Osmitrol
Term
Urea - osmotic diuretic
 Definition
Ureaphil
Term
Glycerin - osmotic diuretic
 Definition
Osmoglyn, Glyrol
Term
Acetazolamide - carbonic anhydrase inhibitor
 Definition
Diamox
Term
Methazolamide - carbonic anhydrase inhibitor
 Definition
Neptazane
Term
Digoxin - cardiac glycoside
block Na/K ATPase --> inc Ca
toxic
 Definition
Lanoxin -yellow 125; white 250
Term
Digoxin Immune Fab Fragments (ovine) - cardiac glycoside
 Definition
Digibind (antidote for Dig toxicity)
Term
Dopamine - direct & indirect - adrenergic agonist
 Definition
Intropin
Term
Dobutamine - adrenergic agonist; direct
 Definition
Dobutrex
Term
Amrinone -PDE III inhibitor
 Definition
Inocor
Term
Milrinone -PDE III inhibitor
 Definition
Primacor
Term
Aspirin
 Definition
Inhibitors of Cyclooxygenase
Term
Clopidogrel - inhibitor of ADP
 Definition
Plavix
Term
Dipyridamole -PDE V inhibitor
 Definition
Persantine
Term
Abciximab -GP IIb/IIIb receptor blocking agent
chimeric monoclonal Ab FAB frag
irreversible
 Definition
Reopro
Term
Tirofiban -GP IIb/IIIb receptor blocking agent
nonpeptide inhibitor; RGD mimic
reversible
 Definition
Aggrastat
Term
Eptifibatide -GP IIb/IIIb receptor blocking agent
synthetic peptide; cyclic RGD peptide; stable
reversible
 Definition
Integrilin
Term
Enoxaparin -LMWH 7 & 10
 Definition
Lovenox
Term
Dalteparin -LMWH 7 & 10
 Definition
Fragmin
Term
Tinzaparin -LMWH 7 & 10
 Definition
Innohep
Term
Fondaparinux -Indirect Thrombin Inhibitors
Injection; only pentasach; need AT3
Kidney; no antidote
 Definition
Arixtra
Term
Rivaroxaban -Indirect Thrombin Inhibitors
don't need AT3; PO; liver;
 Definition
Xarelto
Term
Hirudin,Hirulog,Hirugen
 Definition
Direct Thrombin Inhibitors
Term
Recombinant hirudin - Direct Thrombin Inhibitors
 Definition
lepirudin – Refludan
Term
Bivalirudin - Direct Thrombin Inhibitors
doesn't last long
 Definition
Angiomax
Term
Argatroban - Direct Thrombin Inhibitors
rapid & short duration
 Definition
Acova
Term
Desirudin - Direct Thrombin Inhibitors
SQ
 Definition
Iprivask
Term
Dabigatran - Direct Thrombin Inhibitors
POBID
acid environment required
 Definition
Pradaxa
Term
Warfarin - inhibitor of synthesis of Vit K dependent Coagulation factors(2, 7, 9, 10, protein C & S)
 Definition
Coumadin
Term
Streptokinase -Thrombolytic agent
NS; nondirect
 Definition
Streptase
Term
Urokinase -Thrombolytic agent
direct; NS; not widely used
 Definition
Abbokinase
Term
APSAC (acylated plasminogen streptokinase activator complex) - Thrombolytic agent
possible fibrin selective
 Definition
anistreplase – Eminase
Term
tPA - alteplase -Thrombolytic agent
frequent bleeding @ high dose; fibrin selective
 Definition
Activase
Term
rPA -reteplase -Thrombolytic agent
long duration; less binding & affinity; penetrate longer
fibrin selective
 Definition
Retavase
Term
Tenecteplase -Thrombolytic agent
not inhibited by PAI
fibrin selective
 Definition
TNKase
Term
Drotrecogin alfa activated - activated protein C
anticoagulant
 Definition
Xigris
Term
Epsilon aminocaproic acid - binds to lysine-binding sites on both plasminogen and plasmin
anticoagulant
 Definition
Amicar
Term
Aprotinin -taken off market; lots of death; blocked plasmin, tPA & factor 12a
anticoagulant
 Definition
Trasylol
Term
Benazepril and amlodipine
 Definition
Lotrel
Term
Enalapril and felodipine
 Definition
Lexxel
Term
Trandolapril and verapamil
 Definition
Tarka
Term
Valsartan and Amlodipine
 Definition
Exforge
Term
Olmesartan and Amlodipine
 Definition
Azor
Term
Triamterene / Hydrochlorothiazide
 Definition
Dyazide
Term
Spironlactone/ HCTZ
 Definition
Aldactazide
Term
Lisinopril / Hydrochlorothiazide
 Definition
(Zestoretic)
Term
Benazepril/ HCTZ
 Definition
(Lotensin HCT)
Term
Valsartan / Hydrochlorothiazide
 Definition
(Diovan HCT)
Term
Losartan potassium / Hydrochlorothiazide
 Definition
(Hyzaar)
Term
Olmesartan / Hydrochlorothiazide
 Definition
(Benicar HCT)
Term
Aliskiren/ HCTZ
 Definition
(Tekturna HCT)
Term
Labetalol -BB 3rd gen
 Definition
Trandate, Normodyne B1, B2 maybe a1
Term
Dorzolamide - Carbonic anhydrase inhibitor
Gluacoma
 Definition
(Trusopt)
Term
Brinzolamide - Carbonic anhydrase inhibitor
Gluacoma
 Definition
(Azopt)
Term
Vaprisol - non selective AVP blocker
 Definition
(Conivaptan)
Term
Samsca - V2 selective AVP blocker
 Definition
Tolvoptan
Term
Dichlorophenamide - Carbonic anhydrase inhibitor
 Definition
Daranide
Term
Exanta - Off market, Direct Thrombin Inhibitor
 Definition
Ximegalatran- hepatic damage
Term
Telmisartan + Hydrochlorothiazide- ARB combination
 Definition
Micardis HCT
Term
Eprosartan Mesylate + Hydrochlorothiazide ARB combination
 Definition
Teveten HCT
Term
Irbesartan + HCTZ - ARB combination
 Definition
Avalide
Term
Dorzolamide and Timolol - Carbonic anhydrase inhibitor
Gluacoma
 Definition
(Cosopt)
Term
Homotropine
 Definition
diagnostic agent-mydriasis/cylcoplegia
Term
Infliximab - Anti TNF chimeric monoclonal AB
 Definition
Remiciade
Term
Adalimumab - Anti TNF chimeric monoclonal AB
 Definition
Humira
Term
Unfractionated Heparin
 Definition
inhibits activated: 2, 7, 9, 10, 11 & 12
indirect thrombin inhibitors
Negative charge- Kidney excretion
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