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Exam 1 Review
Immunology Exam 1
87
Biology
Undergraduate 3
11/25/2014

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Term
Classify to following as to whether it is an external or internal defense mechanism:
Stomach acid
Definition
External Defense
Term
Classify to following as to whether it is an external or internal defense mechanism:
C-Reactive Protein
Definition
Internal Defense
Term
Classify to following as to whether it is an external or internal defense mechanism:
Cilia
Definition
External Defense
Term
Classify to following as to whether it is an external or internal defense mechanism:
Neutrophils
Definition
Internal Defense
Term
Classify to following as to whether it is an external or internal defense mechanism:
Complement
Definition
Internal Defense
Term
T cells which respond to self antigens are usually destroyed by the _____
Definition
Thymus
Term
T or F:
ABYs can be labeled with the fluorochrome fluorescein isothiocyanate (FITC)
Definition
True
Term
Use the following results to answer the question:
Total WBC = 5,000/microliter
Basophils 1%
Eosinophils 4
Neutrophils 40%
Lymphocytes 45%
Monocytes 10%
CD3 70%
CD4 40%
CD8 30%
CD19 20%
CD16 10%

The absolute T cell count is:
Definition
1575/micro liter
Term
T or F:
Interleukin is a cytokine
Definition
True
Term
T or F:
T cells are not included as a Phagocytic cell
Definition
True
Term
T of F:
AGN immunogenicity is NOT influenced by the molecular size of the substance
Definition
False
Term
Use the following to answer the question:
Mother - A1/A19, B5/B37, Cw1/Cw11, DR2/DR7
Man A - A3/A28, B14/B35, Cw5/Cw7, DR3/DR9
Man B - A1/A31, B12/B37, Cw2/Cw5, DR12/DR18
Child - A1/A3, B5/B35, Cw1/Cw7, DR2/DR3

Based on these results, which man is the father?
Definition
Man A
Term
Use the following results to answer the question:
Total WBC = 7,000/microliter
Basophils 1%
Eosinophils 4
Neutrophils 45%
Lymphocytes 40%
Monocytes 10%
CD3 70%
CD4 45%
CD8 25%
CD19 20%
CD16 10%

The absolute B cell count is:
Definition
560 / micro liter
Term
T or F:
B cells are derived from plasma cells
Definition
False
Term
Match the type of immunity with the following substance or activity:
Activated T helper cells
Definition
Acquired
Term
Match the type of immunity with the following substance or activity:
Inflammation
Definition
Natural
Term
Match the type of immunity with the following substance or activity:
Phagocytosis
Definition
Natural
Term
Match the type of immunity with the following substance or activity:
ABY Production
Definition
Acquired
Term
In which stage of B cell differentiation are IgM heavy chains developed?
Definition
Pro-B
Term
A T cell receptor (TCR) binds to:
Definition
AGN
Term
T or F:
The polymerase chain reaction (PCR) amplifies all the DNA in a test tube multiple times
Definition
False
Term
A cell which can display cytotoxic activity on tumor cells WITHOUT interacting with APCs is the:
Definition
NKC
Natural killer cell
Term
Cells are identified in flow cytometry by:
Definition
Combining forward and side scatter data
Term
When a cytokine acts on the cell which produced it
Definition
Autocrine
Term
ABY binding site
Definition
Epitope
Term
Substance added to vaccine to stimulate immune response
Definition
Adjuvant
Term
Cell self destructs
Definition
Apoptosis
Term
Substance which facilitates phagocytosis
Definition
Opsonin
Term
HLA - linked genes
Definition
Haplotype
Term
Substance which stimulates proliferation of many different clones of lymphocytes
Definition
Mitogen
Term
Different forms of a gene
Definition
Allele
Term
An immunogen only when combined with a carrier molecule
Definition
Hapten
Term
Memory-secondary immune response
Definition
Anamnestic response
Term
Glycoprotein formed in response to AGN
Definition
ABY
Term
Protection normally present at birth
Definition
Natural immunity
Term
Binding of two complementary strands of DNA
Definition
Hybridization
Term
First IgM predominant Ig; then heavy chain changes to IgG, A, or E
Definition
Class switching
Term
Lymphoid tissue located under skin epithelia
Definition
CALT
Term
Tumor marker
Definition
Beta 2 microglobulin
Term
When a cytokine acts on a cell that is far away from the one that produced it
Definition
Endocrine
Term
AGN presenting cells (APC) do not include:
Definition
Basophils
Term
Markers which must be on a thymocyte before it can be called a double-positive cell are:
Definition
CD4 and CD8
Term
T or F:
Memory cells have a relatively long life span
Definition
True
Term
Use the following results to answer the question:
Total WBC = 7,000/microliter
Basophils 1%
Eosinophils 4
Neutrophils 45%
Lymphocytes 40%
Monocytes 10%
CD3 70%
CD4 45%
CD8 25%
CD19 20%
CD16 10%

The ratio of Helper to cytotoxic T cells is:
Definition
1.8:1
Term
T or F:
The paracortex region of lymph nodes is the home of B cells
Definition
False
Term
T or F:
T lymphocytes are found primarily in the follicles of the secondary lymphoid tissues
Definition
False
Term
T or F:
Plasma cells are effector cells
Definition
True
Term
T or F:
NK cells can kill target cells through a process known as Antibody-dependent cell cytotoxicity (ADCC)
Definition
True
Term
A marker NOT found on T helper cells is:
Definition
CD8
Term
A type of cell often associated with chronic inflammation is:
Definition
Lymphocytes
Term
T or F:
A nucleic acid probe is designed to detect only a specific piece of DNA (or RNA)
Definition
True
Term
AGNs derived from individuals from different species are BEST described as
Definition
Heteroantigens
Term
T or F:
The Th2 helper subset occurs in response to intracellular microbes
Definition
False
Term
When a pregnant woman, chronically infected with HBV, gives birth, the child is given Hepatitis B immunoglobulin (contains ABY to HBV). This type of immunity is best described as:
Definition
Passively acquired
Term
T or F:
Cell markers typically present on B cells do NOT include CD56
Definition
True
Term
Primary lymphoid tissue includes the:
Definition
Bone Marrow
Term
Match the organ with its activity:
Site of B cell maturation
Definition
Bone Marrow
Term
Match the organ with its activity:
Site of T cell maturation
Definition
Thymus
Term
Match the organ with its activity:
Location of hematopoietic stem cells
Definition
Bone Marrow
Term
Match the organ with its activity:
Site of AGN-Dependent lymphopoiesis
Definition
Lymph nodes/spleen
Term
Match the organ with its activity:
Site of AGN-Indepedent lymphopoiesis
Definition
Bone Marrow
Term
The immunoglobulin present on immature B cells is:
Definition
IgMm
Term
Use the following results to answer the question:
Total WBC = 5,000/microliter
Basophils 1%
Eosinophils 4
Neutrophils 40%
Lymphocytes 45%
Monocytes 10%
CD3 70%
CD4 40%
CD8 30%
CD19 20%
CD16 10%

The percentage of NKC in this patient is:
Definition
Normal
Term
Listed below are the steps that occur during phagocytosis - in no particular order. Place them in the correct order:
A. formation of pagosome
B. physical contact between the phagocytic cell and foreign material
C. Exocytosis
D. formation of phagolysosome
Definition
B, A, D, C
Term
An example of an acute phase reactant is:
Definition
Complement
Term
T or F:
A flow cytometer can be used to detect specific cell AGNs
Definition
True
Term
T or F:
Tumor necrosis factor has antiviral activity
Definition
False
Term
Match the cell marker with its characteristic:
Co-receptors that bind to MHC molecules
Definition
CD4 & CD8
Term
Match the cell marker with its characteristic:
Responsible for sheep RBC rosetting around T cells
Definition
CD2
Term
Match the cell marker with its characteristic:
Marker associated with TCR
Definition
CD3
Term
Match the cell marker with its characteristic:
Leukocyte AGN
Definition
CD45
Term
Match the cell marker with its characteristic:
Marker of B cells
Definition
CD19
Term
Which of the following haplotypes belongs to the mother?
Mother - A1/A19, B5/B37, Cw1/Cw11, DR2/DR7
Man A - A3/A28, B14/B35, Cw5/Cw7, DR3/DR9
Man B - A1/A31, B12/B37, Cw2/Cw5, DR12/DR18
Child - A1/A3, B5/B35, Cw1/Cw7, DR2/DR3
Definition
A1, B5, Cw1, DR2
Term
The immunoglobulin that appears first in a primary antigenic stimulus is
Definition
IgM
Term
Ankylosing spondylitis is associated with which HLA AGN?
Definition
B27
Term
T or F:
Acute phase reactants usually INCREASE immediately after an injury
Definition
True
Term
A cell associated with allergies is:
Definition
Eosinophils
Term
T or F:
CD4 cells facilitate the development of humoral immunity but not cell mediated immunity
Definition
False
Term
T or F:
T cell dependent AGNs produce a stronger immune response than T cell independent AGNs
Definition
True
Term
Use the following results to answer the question:
Total WBC = 6,500/microliter
Basophils 1%
Eosinophils 4
Neutrophils 40%
Lymphocytes 45%
Monocytes 10%
CD3 70%
CD4 40%
CD8 30%
CD19 20%
CD16 10%

The absolute T helper cell count is:
Definition
1170 / micro liter
Term
Classify the following as MHC Class I or II Antigens:
Located on gene loci: A, B, C
Definition
MHC Class I antigens
Term
Classify the following as MHC Class I or II Antigens:
Involved in T cell activation by superantigens
Definition
MHC Class II antigens
Term
Classify the following as MHC Class I or II Antigens:
Involved in B cell-T helper cell interactions
Definition
MHC Class II antigens
Term
Classify the following as MHC Class I or II Antigens:
Involved in protecting the host from defects WITHIN host cells
Definition
MHC Class I antigens
Term
Classify the following as MHC Class I or II Antigens:
This class is expressed only on B cells, activated T cells, macrophages, monocytes, dendritic cells, and the endothelium
Definition
MHC Class II antigens
Term
Classify the following as MHC Class I or II Antigens:
Expressed by ALL nucleated cells
Definition
MHC Class I antigens
Term
T or F:
One of the functions of cytotoxic T cells is the removed of virally infected cells
Definition
True
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