Term
| aromatase is what kind of enzyme |
|
Definition
|
|
Term
| aromatase converts 2 adrogen to what? |
|
Definition
testo to estradoil
androtesenion-> estrone |
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|
Term
| rxns with aromatase occur in what tissues-5 |
|
Definition
| ovary, liver, msucle, adipose, breast |
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|
Term
| in _ menopause the aromatizing is the majority circ estrogen. **therefore only able to tx these types of ppl with these antagonists! |
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Definition
|
|
Term
| what are hte non steroidal aromatase inhb-2 |
|
Definition
|
|
Term
non selective aramatase inhibtion affect both-
selective jsut affect? |
|
Definition
ovarian an dadrenal steroidgenesis
(adrenl-cortisol, aldosterone)
ovarian (estrone, estradoil) |
|
|
Term
| the 3rd gen armot inhibit-3 |
|
Definition
anastrazole
exemestane
letrozole |
|
|
Term
| beenfits of being 3rd generaiton aromt inhb. -3 |
|
Definition
more potent
less toxic
more specific/less adrenal insuff |
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Term
| anastrazole and letrazole are used for post nad pre-men women when tamoxifen cant be used |
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Definition
|
|
Term
| emetic effect of anastrazole and letrazole |
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Definition
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Term
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Definition
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|
Term
| ADes of anastrazole ANd LETRAZOLE-3 |
|
Definition
hot flash
headache
bone pain |
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|
Term
which med is a cytochrome P450 3A4
inhbt? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| what med is 2A6 and 2C19 inhibitor |
|
Definition
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|
Term
| which med cna be used as prevention for psot menopausla women with hgih risk of breast cancer? |
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Definition
|
|
Term
| whcih med is a suicide/irreverible inhibtor of aromatase? |
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Definition
|
|
Term
| which med doenst have effect on other steroidgenesis enzymes and indicated for breast cancer? |
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Definition
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Term
|
Definition
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|
Term
|
Definition
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|
Term
| ADE of exemstane bsides the ones for letrazole and anastrazole-2 |
|
Definition
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|
Term
postrate cnacer depedns on what hromeoens?
mostly? |
|
Definition
|
|
Term
what accounts for 95% of androgen production?
what is the exact hromen rpoduced? |
|
Definition
hypothalmul-pituitary-testes
testosterone |
|
|
Term
what regulates androgen rpoduction for 5%?
what is the hormone? |
|
Definition
hypothalmus-pituiutary-adrenal
andrastendion |
|
|
Term
| testosterone is converted to DHT in rpostate by? |
|
Definition
|
|
Term
DHT in porstate changes gene expression.
what adrogen can mimic this? |
|
Definition
|
|
Term
| the androgen recpt has 3 parts- *transactive, DNa binding, DHT binding |
|
Definition
|
|
Term
| what is surgicla removal of testicles |
|
Definition
|
|
Term
| what are 4 ways to remove androgens and help protate cancer |
|
Definition
srugery removal of testicles
block testost production
block conversion to DHT
block testost effects |
|
|
Term
| what hormones increases testorone? |
|
Definition
|
|
Term
|
Definition
| chronic admin of this eventually inhibits LH secrection bc LHRH pituitary recpt decrease-> lower testost |
|
|
Term
| LHRH are like estrogen anticancer meds but w/o? |
|
Definition
|
|
Term
|
Definition
leuprolide
goserelin
triptorelin |
|
|
Term
after LHRH agonists, peak LH occurs at?
peak testost at?
test castration (0%) is at- |
|
Definition
|
|
Term
| what are the anti-androgens (block AR)-3 |
|
Definition
flutamide
biculatmide
nilutamide |
|
|
Term
|
Definition
|
|
Term
|
Definition
| gyncomastia, decreased libido, elevated liver enzymes |
|
|
Term
| what drug increases warfarin effect?-2 |
|
Definition
|
|
Term
| ADE of bicalutamide is similar to flutamide, but also has- |
|
Definition
|
|
Term
|
Definition
|
|
Term
| emetic effects of the anti-androgen meds |
|
Definition
|
|
Term
| ADE of nilutamide in addition to to flut/bical ones |
|
Definition
|
|
Term
| which drug has the disulfurm rxn to alcohol |
|
Definition
|
|
Term
|
Definition
|
|
Term
| LHRH agnets also decrease estrogen and progesterone in premenopausla females* |
|
Definition
|
|
Term
|
Definition
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|
Term
ADes of leuprolide, goserelin:
male-3
female-3 |
|
Definition
testicular atrophy, impotence, hot flash
hot flash, amennorhea, vaginits |
|
|
Term
dosing if 3.5 or 7.5 mg leuporlide
if 22.5-30 mg |
|
Definition
|
|
Term
| which drug cna cause tumor flare?-3 |
|
Definition
| leuprolide, goserelin, triptorelin |
|
|
Term
| leuprolide is contraindicated in |
|
Definition
|
|
Term
| which leuporlide is approved for endometriosis? |
|
Definition
|
|
Term
|
Definition
|
|
Term
Goserelin dosing
3.6 mg
10.8 mg |
|
Definition
|
|
Term
| goserlin is contraidnicated in |
|
Definition
|
|
Term
triptorelin dosing for
3.75 mf
11.25 mg |
|
Definition
|
|
Term
| how is triptorelin admin? |
|
Definition
|
|
Term
| what additonal ADE from the toher LHR agonists does triptorelin have? |
|
Definition
|
|
Term
MOA of croticosteroids in cancer
they bind to what recpt? |
|
Definition
lymphopenia is cytotoxic to leukemia lymphoblastas
glucorticoid recpt in nucelus |
|
|
Term
| corticosteroids induce apoptosis using supra concn. it will affect what cells- |
|
Definition
lymphocytes
plasma (myelomas) |
|
|
Term
| what corticosteorids are used in cancer-3 |
|
Definition
prednisone
methylprednisolone
dexmethasone |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| what steroids are used for non hodgkins |
|
Definition
prednisone
methylprednisolone |
|
|
Term
|
Definition
|
|
Term
| dexmethasone is used for what cancer? |
|
Definition
|
|
Term
| ADEs of corticosteorids-3 |
|
Definition
cuhsign;s
hyperglycemia
edema |
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|
