Term
| doxorubicin affects DNa by- |
|
Definition
| intercalation of base pairs |
|
|
Term
| belomycin affects DNa thru |
|
Definition
|
|
Term
| mitomycin affects DNA thru |
|
Definition
|
|
Term
| mjaor mechnisams of ABX are-2 |
|
Definition
free radical generaiton
Topo II inhibition thru intercalation |
|
|
Term
| anthracyclines have tetracycline ring with what sugar |
|
Definition
|
|
Term
| agnets of the anthracyclines have a _ moeities to funct as both e-donating nad accepting |
|
Definition
|
|
Term
| the 3 MOAs of anthrcyclines |
|
Definition
-interaclate nucelotide pairs
-complex with helices to dissoc DNA
-complex with topo IIs |
|
|
Term
| how do the anthracyclines differ?-3 |
|
Definition
hydroxyl group
oxidation
carboxycylic ester |
|
|
Term
route of admin for doxorubicin
dosage form? |
|
Definition
|
|
Term
| freq of admin for doxorubicin |
|
Definition
| IV q 3 wks, or Iv for 3 days every q 3 weeks |
|
|
Term
| Doxorubicin is in what class |
|
Definition
| anthracyclines (so ahs these MOAs) |
|
|
Term
| doxorubicin is a _ that can produce free radicals to cleave DNA |
|
Definition
|
|
Term
doxorubicin is CCS, or CCNS.
what is odd about this tho |
|
Definition
CCNS
it is max cytotox in phase S |
|
|
Term
| mechansims of resistance to doxorubicin-3 |
|
Definition
decreased topo IIs
increase GSH
P-glycoprotein efflux pump |
|
|
Term
| doxorubicin is used for what cancers-3 |
|
Definition
sacromas
carcinomas
hematolgic cancers |
|
|
Term
| doxorubicin is most oftne in combo with- |
|
Definition
| AdOAP (adiramycin, oncovin, ARA-c/cytarabine, prednisone |
|
|
Term
|
Definition
|
|
Term
what drugs delay effect of doxorubicin?
how? |
|
Definition
barbituates
increase CYP3A4 |
|
|
Term
| what drugs cause cardiotox with doxorubicin? |
|
Definition
|
|
Term
|
Definition
cardiovasc
GI
genitourinary-
hematologic/myelosupp
hyperuricemia |
|
|
Term
| what med causes red urine |
|
Definition
|
|
Term
| which topo is NOT affecter by intercalating agents? |
|
Definition
|
|
Term
what rxn can topo II still do even with intercalating agents?
which cant it do? |
|
Definition
scission of DNA
relegation |
|
|
Term
| anthracyclins have hgih risk for carrdiotox* |
|
Definition
|
|
Term
| anthracyclin CHF is increased when pt have preexisitng- |
|
Definition
|
|
Term
| dose of _ has 48% of anthracyclin induced CHF |
|
Definition
|
|
Term
| Tx with anthracyclins must stop when cumm. dose >- |
|
Definition
|
|
Term
| counseling for doxorubicin-3 |
|
Definition
monitor total dose
no bolus
cardiac risk factors |
|
|
Term
cardiotox with doxirub:
acute= w/i minutes
subacute- within 1 yr
late onset- years fter |
|
Definition
|
|
Term
basis of cardiotox of dox part 1:
-_ strucutre permits E-accept and is catalzed by-2 in cardiac tissue |
|
Definition
|
|
Term
basis of cardiotox with dox part 2:
semiquinone forms donate e- to _ to form _ whcih cause- |
|
Definition
oxygen
hydroxyl radicals
DNA damage/destroy cardiac myoctes |
|
|
Term
| cardaic tissue doesnt have many enzymes to get rid of free radicals to convert _ to water |
|
Definition
|
|
Term
| anthracyclines have high affinty to bind _ which is another way to produce cardaic damaging radicals |
|
Definition
|
|
Term
what is the agent used to reduce cariotox from anthracyclines?
MOA? |
|
Definition
dexrazoxane
accepts the iron from anthracyclines to prevent iron radicals (intracell chelating agent) |
|
|
Term
| when is dexrazoxane given? |
|
Definition
|
|
Term
for Tx of Kaposi cancer, what drugs are available in liposomal form?-2
what does this form do? |
|
Definition
doxirubicin (Doxil)
daunorubicin
increase plasma circ x 100 fold (55hr) |
|
|
Term
| Ades of doxirubicin+ liposome form-2 |
|
Definition
| erethyma and skin sloughing on sole/palms |
|
|
Term
dactinomycin does what to DNA?
this complex then does wha? |
|
Definition
intercalate guanine-cytosine (topo II)
blocks RNA polymrease- DNA trnascp |
|
|
Term
| resistance to dactinomycin-2 |
|
Definition
effluc p-glycoprotein
DNa repair |
|
|
Term
| indications for dactinomycin?-3 |
|
Definition
|
|
Term
| less freq ueses for dactinomycin-4 |
|
Definition
melanoma
testic
uterine
germ cell |
|
|
Term
max dose of dactinomycin?
freq? |
|
Definition
15 mcg/kg/day
2 wk cycles |
|
|
Term
dactinomycin admin-
does it cross BB? |
|
Definition
|
|
Term
|
Definition
N/V
skin irritation/extravasation |
|
|
Term
| dactinomycin is vesicant or not? |
|
Definition
|
|
Term
| need to avoid what med with preggo? |
|
Definition
|
|
Term
| mitoxantrone vesicant or not? |
|
Definition
|
|
Term
|
Definition
| intercalates and affect Topo II |
|
|
Term
with anthracycline is less cardiotox?
why? |
|
Definition
mitoxantrone
no free radicals |
|
|
Term
| mitoxantrone can be used for-3 |
|
Definition
| breast, myelogeius leukemia, lymphomas |
|
|
Term
what is the bifunctional alkylating ABX with aziridine ring?
what crosslinks does it make? with what bases-2 |
|
Definition
mitomycin
intrastrand; G-G, A-G |
|
|
Term
|
Definition
|
|
Term
| resistance to mitomycin comes from-3 |
|
Definition
diaphorase
inactive quinine
efflux pump |
|
|
Term
| mitomycin can be used for what cancers-4 |
|
Definition
|
|
Term
| mitomycin is incompatible with-4 |
|
Definition
vinca alkaloids
etoposide
filgrastim
gemcitabine |
|
|
Term
single agnet tx with mitomycin freq:
comination therapy |
|
Definition
|
|
Term
|
Definition
|
|
Term
| mitomycin high conc not found where in the body? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| belomycin main forms A2 and B2* |
|
Definition
|
|
Term
| bleomycin are water sol/insol, _ molecules |
|
Definition
|
|
Term
| belomycin forms complexes with- |
|
Definition
|
|
Term
the bleomycin+_ complex has no anittumor act?
when is it active? |
|
Definition
|
|
Term
| cytotoxic effects of blemoycin is due to- |
|
Definition
| oxidative damage to deoxyribose of thymidalte -> DNa breaks |
|
|
Term
| which med mediates lipid peroxidaiton |
|
Definition
|
|
Term
|
Definition
increased belomycin hydrolase
GSH
efflux |
|
|
Term
| which med cna be used for pleural effusions? |
|
Definition
| bleomycin (intracivity injeciton) |
|
|
Term
| look at slide near ppt end wiht star to see idnicaitons for bleomycin |
|
Definition
|
|
Term
| which anticancer drug is the most pulm toxic? |
|
Definition
|
|
Term
MOAS:
inhibits DNa and RNA synth-
prevents transc-
degrade preformed DNA
degrade thru radicals/alkylation |
|
Definition
|
|
Term
| which meds are by parenteral route (Iv, IM, etc)-2 |
|
Definition
|
|
Term
|
Definition
alleric rxn
hyperpyrexia
pulmn fibrosis |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
hair loss
necorsis
myelop supp
carido |
|
|
Term
indicaitons for:
doxyr-3
dactino-2
bleo-3
mitomy-2 |
|
Definition
breast carcin, hodkins, non hodgkins
wilms, rhabdosarc
hodgkins, testicular, pleural effus
anal, bladder |
|
|
Term
| what are the only two ABX not vesicants |
|
Definition
|
|
Term
| a unique ABX toxicity is hemolytic uremic syndrome |
|
Definition
|
|
Term
what is a marker for Dox cardiotox?
why? |
|
Definition
BNP
rises with left vent dysfunct |
|
|
