Term
topoisomerases are?
they are in what organisms? -2 |
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Definition
nucelar enzymes
prokaryotes, eukaryotes |
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Term
| what is the action of topoisomerases? |
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Definition
| catalyze intervoncersion of DNA/ nick closing enzyme |
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Term
| topoisomerases are requireed for cell viability (neg DNA superhelix?)** |
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Definition
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Term
| Type 1 topoisomerases MOA- |
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Definition
| nicks a strnad of DNA, then prevent rotation -> passes other strnad through and cuts the end |
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Term
| the end result of type 1 topoisomerases- |
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Definition
| 1 less neg supercoil on the DNA |
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Term
topoisomerases solve what problems?
by untangling _ for replication and seperating_ |
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Definition
topological
positive supercoils; catananes |
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Term
| topoisomerases nicks DNA but then reseals it; is essential for replicaiton (sepearting strnads and replicaiton!**** look at slide 6 |
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Definition
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Term
Ttopoisomerases 1 break _ chains
what does 2 do? |
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Definition
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Term
Topo 1 and topt2 similar func is?
topo 2 has what other one? |
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Definition
removes psotive supercoils during trnascription
-seperates chromosomes in mitosis |
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Term
without anti-neoplastic agent the Topo has equilibrium btwn what two things?
which the antineoplastic agents whihc one has more? |
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Definition
cleavage
religation
cleavage |
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Term
| ask someone about slide 9 before test |
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Definition
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Term
| MOA of antitopoisomerases agents0 |
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Definition
| cause accumulation of DNA cleavages-> apoptpsis |
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Term
| what are the Top II inhibitors-2 |
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Definition
etoposide
teniposide
(epidophyllotxins) |
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Term
| *podophyllintox bidns with tublulin, etoposide does not alter microtubules |
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Definition
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Term
| epidophyllotxins (etoposide and teniposide) are CCS or CCNS |
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Definition
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Term
| what cycel phase doe epipodophyllotxins wrok-2 |
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Definition
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Term
| where do epidophyllotxins stop cell replicaiton at? |
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Definition
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Term
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Definition
| lung, testicular, lymphomas |
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Term
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Definition
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Term
which is elminated slower, etoposide or tenoposide?
which has higher hypersens and why? |
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Definition
teniposide (also mroe potent)
teniposide, bc of castor oil formulation |
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Term
| ADes of tenoposide and etoposide-2 |
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Definition
| nuetropenia, meylosuppresion |
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Term
| admin of etoposide nad teniposide are for how mnay days? |
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Definition
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Term
| what drugs do you need ot reduce dose for low Cr cl?-2 |
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Definition
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Term
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Definition
camptothecin
irinotecan
topotecan |
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Term
| are the thecins CCS or CCNS |
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Definition
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Term
| the thecins are water soluble/insoluble and admin by_ |
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Definition
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Term
| irinothecan was approved for what cancer-2 |
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Definition
5-FU refracotry colorecal
also pedatric tumors |
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Term
| topothecan was approved for- |
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Definition
| ovarian cancer (2nd line) |
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Term
| the thecans are metab thru? |
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Definition
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Term
| half life longer for topthecan or inriothecan |
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Definition
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Term
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Definition
| meylosupp, neutropenia, N/D |
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Term
| for Cr Cl of 40-60, topotecan dose reduced to- |
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Definition
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Term
| if pt had neutropenia > 3 d, dose of topotecan reduce to- |
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Definition
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Term
| whcih thecan is a prodrug and needs to be metaboliccly activated to 7-ehtyl, hydroxycamptotjeic (SN-38)? |
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Definition
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Term
| *irinotecan pts can have dirrhea within hrs of infusion |
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Definition
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Term
| consider _ when irinotecan pt has cholinergic symtpoms with their diarrhea? |
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Definition
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Term
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Definition
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Term
| to controll delayed onset odiarreha with inriotecan, cang ive oral dose of _ q 2 hr in day and q4h at night |
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Definition
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