Term
| microtubuels are the most strategic _ target |
|
Definition
|
|
Term
| microtubules are static/dynamic? |
|
Definition
| dynamic (undergo assembly and dissembly a lot) |
|
|
Term
| microtubules determine what for a cell-2 |
|
Definition
cell shape
intracell movement of organelles |
|
|
Term
microtubules have a role in mitosis/meosis?
what is it? |
|
Definition
mitosis
form mitotic spindle |
|
|
Term
| microtubules are invovled in what intracell proceses?-4 |
|
Definition
trnapsort, secretion, neurotransmission
singal trnasuction |
|
|
Term
| microtubules made of alpha adnd beta _ subunits |
|
Definition
|
|
Term
| microtubule assembly and dissembly are in dynamic equil. but depedn on what 2 things- |
|
Definition
|
|
Term
microtubule agetns/anti-mitotics classes-3
which inst useful for cancer bc so toxic? |
|
Definition
taxanes
vinca alkaloids
colchine
colchine |
|
|
Term
| how must all anti-mitotic agents be admin? |
|
Definition
|
|
Term
| look at sldie 7 and see if someone understands |
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Definition
|
|
Term
| which drug comes form the madagascar periwinkle |
|
Definition
|
|
Term
| vinblastine and vincristine inhibit? |
|
Definition
| microtubule formation (then do apoptisosi) |
|
|
Term
| indication for vinblastine |
|
Definition
|
|
Term
indicaiton for v
incristine |
|
Definition
|
|
Term
| which has longer half life, vincristine or vinblastine |
|
Definition
| vincristine (85 vs 25 hr) |
|
|
Term
| vinca alkaloids are CCS or CCNS? |
|
Definition
|
|
Term
| vinca alkaloids work in what specific phases? |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| which vinca alkaloid is better tolerated in children |
|
Definition
|
|
Term
| look at slide _ for other uses for vinca alkaloids (more cancers than mentioned in prev slides) |
|
Definition
|
|
Term
| the vinca alkaloids are given how often? |
|
Definition
|
|
Term
| if vincristine is given intrathecal its dealy- why? |
|
Definition
|
|
Term
| are the vinca alkaloids vesicants or not? |
|
Definition
|
|
Term
|
Definition
| leukopenia, GI, peripheral neurop |
|
|
Term
| the major ADEs of vincristine-2 |
|
Definition
| peripheral neuropathy, constipation |
|
|
Term
| vincrisitne cant exceed what dose? |
|
Definition
|
|
Term
| what is vinorelbine used for-2 |
|
Definition
|
|
Term
| what are the ADEs of vinorelbine-2 |
|
Definition
myelosuppression
peripheral neuropathy |
|
|
Term
| which vinca has the least neurotox? |
|
Definition
|
|
Term
| vincas are taken into cells how? |
|
Definition
|
|
Term
vincas bind to high/low affinty _?
this then caises? |
|
Definition
high and low tubulin proteins
depolymerize (dissemble) microtubules |
|
|
Term
| vinca alkaloids arrest cells in what phase? |
|
Definition
|
|
Term
| the major resistnace mech against vinca meds is? |
|
Definition
| MDR-P glycoprotein efflux pump |
|
|
Term
|
Definition
|
|
Term
| whcih med comes from yew trees? |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Taxanes work on what cell cycle phases?-2 |
|
Definition
|
|
Term
| taxanes STABILIZE microtubuels*** this eventually causes them to stack and then not work properply-> apoptosis |
|
Definition
|
|
Term
| which emd group promotes microtubule growth to clog cell up and get apopotsis? |
|
Definition
|
|
Term
| paclitaxol can be used what _ resistant cnacers |
|
Definition
|
|
Term
| paclitaxol production comes from semisynth of _ |
|
Definition
|
|
Term
| what is the analgouge of paclitaxel |
|
Definition
|
|
Term
| Taxanes are used for what cancers4 |
|
Definition
| breast, ovarian, AIDS's Kaposi;s, and lung |
|
|
Term
| the _ is required for taxane biological activty |
|
Definition
|
|
Term
| paclitaxol is hydrophob/phillic and so is? |
|
Definition
|
|
Term
| what lipid solvents have to be given with paclitaxel?-2 |
|
Definition
|
|
Term
| what solvents are givne with docetaxel-2 |
|
Definition
|
|
Term
| *taxanes are dilutes at edn of process 5 fold with saline |
|
Definition
|
|
Term
| taxanes have a lot of hypersensitivty due to |
|
Definition
|
|
Term
| solvent formulation of taxols cause- |
|
Definition
|
|
Term
| the castor oil in taxol formulations is active and its infusion produces_ |
|
Definition
| histamine relase->anaphylaxis |
|
|
Term
| taxol drugs due to hypersensitivty are always admin after premedication of-2 |
|
Definition
antihistamine or cortcosteroids (give 12 hrs prior!)
(diphenhydr, cimedtidine, dexmethasone, etc) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| p450s (so worry with liver!) |
|
|
Term
| paclitaxol is admin how often?-3 diff |
|
Definition
|
|
Term
| what are the main ADes of paclitexol-5 |
|
Definition
| meylosuppresion, alopecia, peripheral neuropathy, myalgia, fatgue |
|
|
Term
| how long before would you give dexmethasone before Taxoo? |
|
Definition
|
|
Term
what kind of tubing is used for Taxol?
why? |
|
Definition
|
|
Term
| if taxol is given with other chemo, is it first or last? |
|
Definition
|
|
Term
| which more potent, Taxol or docetaxel |
|
Definition
|
|
Term
| Docetaxel is admin how often |
|
Definition
|
|
Term
|
Definition
| mylepsuppr, myaglia, peripheral neruo, alopecia |
|
|
Term
| pre-med of dexmethasone for docetaxol- |
|
Definition
| BId x 1 d prior, then for 4 days after |
|
|
Term
| what is the solvent (Cremophor) free paclitaxel formulation |
|
Definition
|
|
Term
| what is the good thing about abroxane? |
|
Definition
| can give high dose paclitexal |
|
|
Term
| in _ cancer, abraxane has mroe acitvity than Taxol |
|
Definition
|
|
Term
| * abraxane is 45% protein/albumin bound |
|
Definition
|
|
Term
| mechanisms of resistance agaisnt taxanes-2 |
|
Definition
efflux pump
alterations of tubulin proteins |
|
|
Term
| slide 27 has breast cancer regiens with taxol. maybe read, prob not important |
|
Definition
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|
