Term
| what are the pyrimidine analogues-4 |
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Definition
flueouricil
floxuridine
capecitabine
cytarabine |
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Term
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Definition
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Term
| fluorouricl is phosphylated to-2 |
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Definition
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Term
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Definition
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Term
| FtUMP is a tight binding inhibitor of |
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Definition
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Term
| fluroribonucleotides are incoroporated into- |
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Definition
| RNa to mess with splicing, trnasport |
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Term
| fluerodeoxyuridines incorporate into- |
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Definition
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Term
| the prinicpal MOA of 5-FU is |
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Definition
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Term
| depletion of intracel folate prevents ternary formation (caused by 5 FU)* |
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Definition
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Term
using _ increases cytotoxicity of 5 FU
how? |
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Definition
leuvocorin
expands inatracell 5,10 methyltetrahydro and increase TS inhibiton |
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Term
| slide 8 has 5 FU patho phys. look at before test |
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Definition
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Term
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Definition
| GI, pancrease, head/neck, colon, rectum, breast, ovarian |
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Term
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Definition
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Term
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Definition
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Term
| ask someon what slide 10 means! |
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Definition
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Term
|
Definition
marrow suprr
mucosal N/V
cardiac
hand foot syndrome, alopecia |
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|
Term
| cytosine arabinose (araC) |
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Definition
|
|
Term
|
Definition
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|
Term
| how does cystine arabinose differ from cystine ribose? |
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Definition
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Term
|
Definition
| inhibitions of DNA plymerase alpha and incorportation into DNA (stops DNA repair and replicaiton) |
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Term
| cytarabine is indicated fro |
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Definition
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|
Term
| which antimetabolite is most specific for pahse S? |
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Definition
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Term
|
Definition
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Term
| this drug is activated by kinases to AraCTP |
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Definition
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|
Term
| ADes of cytarabine (the rst on slide 16)-5 |
|
Definition
severe mylosupp
GI (esoph,..
eye (conjuct..)
neuro (cerebell)
rashes |
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|
Term
Capecitabine is a pro drug of?
what is its indicaiton |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
|
Definition
| advanced or metastatic pancreatic cancer |
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Term
| he triphosphate-gemcitabine inhbits |
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Definition
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|
Term
| the diphosphate-gemcitaibine inhibits |
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Definition
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|
Term
| dose limitng tox of gemcitabine |
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Definition
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|
Term
| which has 20 x more conc ARAc or gemcetabine |
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Definition
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|
Term
| resistance to gemcetabine is done by- |
|
Definition
| increased deoxycytidine kinase |
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Term
|
Definition
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|
Term
phosphyrlated fludarabine inhibits
its other MOA is- |
|
Definition
DAN polymerase
incorp into DNA strand-> chain terminate |
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Term
| indicaiton for fludarabine |
|
Definition
| CLL chronic lymp leukemia |
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Term
| fludarabine has besides mylo supp, also had what tox observed-2 |
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Definition
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|
Term
|
Definition
mercaptopurine
thioguanine (6 TG)
cladribine
pentostatin |
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|
Term
| MOA of mercaptopurine (6 MP) |
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Definition
| 6 MP inhibts 1st step of purine synth |
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Term
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Definition
| incorp into DNA and RNA-> fragmentation |
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Term
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Definition
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Term
| the 6-MP rxn is more active in tumor cells* |
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Definition
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Term
| 6 MP inhibits committed step in de novo purine synth |
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Definition
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Term
| what is the substance that activates 6 MP and thioguanine |
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Definition
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|
Term
| resistance to 6 MP and thiogunaine is due to-2 |
|
Definition
decrease HGPRT activity
increased alkaline phosphatases that inactivate nucelotoides |
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|
Term
6 MP is metab in the liver to-
so? |
|
Definition
xanthine oxidase
allopurinol is concurrent to prevent hyperuricemia |
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|
Term
| pearl: if allopurinol used, need to do what with 6 MP? why? |
|
Definition
decrease 75%
prevent heptox, hematox, myelosupp |
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Term
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Definition
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|
Term
| what regulates the effect of thiopurines? |
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Definition
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Term
| if pt has deficient _ becomes sensitive to toxic effects of 6MP and 6 TG |
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Definition
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|
Term
| ribonucelotide reductase catalyzes- |
|
Definition
| ribonucl diphosphates to deoxyribo diphosphates |
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|
Term
ribonucl reductase regulates level of_
activated when?
controlled by?
*is hgihly regulated |
|
Definition
dNTPS
prior to DNA synth
feedback inhibiton |
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Term
| ask someon about slide 28 |
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Definition
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|
Term
| what inhibits ribonucleotide reductase |
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Definition
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|
Term
| what drug inhibits DNA synth without affecting RNA? |
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Definition
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|
Term
| why isnt hydroxyurea used a lot in clinic?q |
|
Definition
| cleared from body too rapidly |
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|
Term
| hydrxyurea indicated for? |
|
Definition
| chronic granulo leukemia, polycythermia vera, sickle cell anemia |
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