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Exam 1
Introduction to ABO Blood Group System
34
Science
Graduate
02/27/2013

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Cards

Term
If a person has an H gene then which antigen is on their red blood cells?
Definition
fucsyl transferases which adds L-fuctose to the base of the immunodominant structure of H antigen
Term
If a person has an A gene then which antigen is on their red blood cells?
Definition
galactosaminyl-transferase that adds N-acetyl-galactosamine to the H (L-fructose) base
Term
If a person has an B gene then which antigen is on their red blood cells?
Definition
galactosyl-transferase adds D-galactose to the H (L-fructose) base
Term
Genotype AB
Definition
Phenotype AB
Term
Genotype AO or AA
Definition
Phenotype A
Term
Genotype BO or BB
Definition
Phenotype B
Term
Genotype O
Definition
Phenotype O
Term
Characteristics of the ABO antibodies
Definition
naturally occurring, anti-b (A blood), anti-a (B blood), both (O blood) or neither (AB blood), Attack foreign antigens on the RBC surfaces
Term
Distinction and practical importance between A1 and weaker subgroups of A.
Definition
A1 gene allows for more A antigens to be expressed on the RBC surface, A2 genes do not code for as many enzymes so not as many antigens are A
Term
A1 blood reacts with
Definition
AntiA1 (positive)
Term
A2 blood reacts with
Definition
AntiA, not AntiA1
Term
Steps to be taken when forward and reverse do not match?
Definition
order a new specimen, wash the specimen (retest), look at patient file, determine the cause of the discrepancy
Term
Who discovered the ABO blood group system and when did he discover it?
Definition
Karl Landsteiner, 1902
Term
What is Landsteiner's Rule?
Definition
reciprocal antibodies are consistently and predictably present in the sera of normal people whose rbcs lack the corresponding antigen

If you have the antibody you CANNOT have the antigen
Term
Describe Group A blood
Definition
A antigens, Anti-B antibody
Term
Describe Group B blood
Definition
B antigens, Anti-A antibody
Term
Describe Group AB blood
Definition
A and B antigens, no antibodies
Term
Describe Group O blood
Definition
neither antigen, anti-a and anti-b antibodies
Term
What does ABO inheritance follow?
Definition
Mendalian Genetics
Term
What is the most frequent blood type?
Definition
O (in whites)
Term
Why do babies give weaker ABO results?
Definition
because antigens are not fully developed
Term
Where are ABO antigens located?
Definition
RBCs, lymphs, platelets, tissue cells, bone marrow and solid organs
Term
Are antigens direct products of genes?
Definition
No, enzymes from genes
Term
What do genes code for?
Definition
transferase enzymes
Term
Immunodominant structure of H antigen
Definition
L-fructose
Term
Immunodominant structure of A antigen
Definition
N-acetyl-galactosamine
Term
Immunodominant structure of B antigen
Definition
D-galactose
Term
An emergency transfusion of packed RBC's is required for a premature newborn. What ABO type should be issued for transfusion?
Definition
O
Term
Which of the following is true of ABO antibodies?
Definition
They are "naturally occuring" antibodies
Term
A2B Dad and A1O Mom =
Definition
OO offspring with O phenotype not possible
Term
Individuals of blood group O have:
Definition
The isoagglutinins A and B in their plasma
Term
Which phenotype is seen more frequently in the "white" population than the "black" population
Definition
A
Term
Given a mother of Group O and an infant of Group B, which of the following blood groups of the questionable father would eliminate his paternity?
Definition
AB
Term
Which of the following ABO blood groups contains the least amount of H substance?\
Definition
A1B
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