Term
symapthetic nervous system decreases blood flow to?
it increases blood flow to? |
|
Definition
gi, kidneys;
muscles, heart |
|
|
Term
| which nervous sytem increases response to flight or fight? |
|
Definition
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|
Term
SNS affects on:
glucose
mental status
oxygen consumption |
|
Definition
-increases
increases
increases |
|
|
Term
which SNS effector acts as a neurotransmitter and a hormone?
-where is the hormone made? |
|
Definition
Epinephrine
-adrenal medula |
|
|
Term
| what is the rate limitng step of synthesis of SNS effectors? |
|
Definition
| tyrosine hydroxylase (tyrosine ->DOPA) |
|
|
Term
| what does PNMT enzyme do? |
|
Definition
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|
Term
which recptor on the SNS presynaptic terminal decreases NE release?
which increases? |
|
Definition
|
|
Term
NE vs. EPi
uptake by presynaptic terminal is better for?
uptake by effector cell is better for? |
|
Definition
|
|
Term
| if uptaken into the effector cell- what enzyme inactivates the SNS effector? |
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Definition
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|
Term
| if uptaken into the presynaptic cleft what enzyme cna inactive the SNS effector? |
|
Definition
|
|
Term
| where are B1 recptors found? |
|
Definition
juxtoglomerulus
myocardium |
|
|
Term
| where are B2 recptors found? |
|
Definition
| smooth muscles and others |
|
|
Term
| which type of recptor (and #) can be on presynatpic and post synaptic? |
|
Definition
|
|
Term
| all adrenorecptors for SNS are what type? |
|
Definition
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|
Term
A1 recptor is what spcific type of recptor?
if activated what will it increase? -3 |
|
Definition
Gq
-inositol triphosphate, diaglycerol, Ca |
|
|
Term
A2 is what recptor?
B (all) is a what recptor? |
|
Definition
|
|
Term
What recptor decreases adenyl cylcase/ cAMP?
which increases? |
|
Definition
|
|
Term
what do A1 recpotrs do to kidneys?
-2 things? |
|
Definition
vasocontriction
Na reabsorption |
|
|
Term
| where are A1 recpt mainly found? |
|
Definition
|
|
Term
| where are B1 recpt mainly found? |
|
Definition
|
|
Term
| which recptor has chrono, ino-tropic, dromotropic effects? |
|
Definition
|
|
Term
| which recpotr increases release of renin? |
|
Definition
|
|
Term
B2 recptor effects on
-smooth muscle arteriole
-" " bronhcial |
|
Definition
vasodilation
dilation and cinreased secretion |
|
|
Term
| which recptor promotes glycogenoylsis and gluconeogenesis in liver and skeletal? |
|
Definition
|
|
Term
| which promotes relaxation and increased intraocular pressure in cilliary part of eye? |
|
Definition
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|
Term
| B3 recpotr causes what in adipocytes? |
|
Definition
|
|
Term
1st gen Beta blockers:
2nd gen Beta blockers:
3rd gen: |
|
Definition
non selective B1 and B2
B1 selective
additional effects |
|
|
Term
beta blockers main site of action is?
when can you see effect from these meds? |
|
Definition
cardiovasc
SNS activty is high- stress, exercise, HTN |
|
|
Term
| what affects on the cardiac output does Beta blocker have -2 |
|
Definition
decrease chronotropic
decrease inotropic
-decrease dromotropic |
|
|
Term
short term effect of non selective Beta blocker? this causes what response?
what recpotrs will this then effect? |
|
Definition
decrease cardaic output->BP
reflexive SNS activation-> Epi/NE
alpha 1->constriciton |
|
|
Term
| what are the dromotropic affects of beta blockers -4 |
|
Definition
reduce sinus rate
decrease automatacity of pacemakers
slow conduction of AV
increase AV refractory |
|
|
Term
| if a beta blokcer has _ property that its effect on automaticity(pacemaker) is increased |
|
Definition
|
|
Term
| Beta blockers can be used to help increase exercise intolerrance how? |
|
Definition
| increase O2 supply and demand with CAD |
|
|
Term
reduction of BP in HTN by beta blocker is done how?
-2 |
|
Definition
decrease cardaic output
decrease renin release |
|
|
Term
| non selective beta blockers have what additoinal effects? |
|
Definition
| decrease NE release (B2 blocking) |
|
|
Term
| selective B1 blockers have what addiotnal effect? |
|
Definition
| vasodilation- thru B2 recptors |
|
|
Term
beta blockers have what effect on the eye?
what specific type of beta blocker does this? |
|
Definition
reduced pressure
nonslective (beta 2) |
|
|
Term
| which beta blocker has decreased recovery of hypoglycemia? |
|
Definition
| non selective (B2 blocked) |
|
|
Term
| besides HTN what diseases cna Beta blockers be used for? |
|
Definition
migraines
glaucoma
MI
arrthymias
angina pectoris |
|
|
Term
| which beta blocker also blocks Ca channel? |
|
Definition
|
|
Term
| which beta blocker also induces NO production -2 |
|
Definition
nebivolol/Bystolic
caretelol/cartol |
|
|
Term
what disease would partial agonist beta blockers be used for?
what are hte meds? -4 |
|
Definition
heart failure
acebutolol
cartelol
penbutolol
pindolol |
|
|
Term
| which beta blocker has antioxidant AND ca blocking activity? |
|
Definition
|
|
Term
what class of meds do you need to taper discontinuation?
why? |
|
Definition
beta blockers
induce angina pectoris (Myocadiral ischemia) |
|
|
Term
| beta blockers ADEs can cause what cardiovascualr effects?-4 |
|
Definition
arryhtmia with AV dysfunction
Heart failure if alreadu compensated
sex dysfunction
worsen PAD |
|
|
Term
| what ADES does beta blocker have on CNS? -3 |
|
Definition
depression
sedation
sleep disturb |
|
|
Term
| what metabolic/enddocrine ADes does beta blocker have? -2 |
|
Definition
mask hypoglycemia tachycardia
increase TGs |
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