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Exam 1
Ch.1-6
124
Physiology
Undergraduate 2
10/28/2012

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Term
Negative Feedback
Definition
Set pt:homeostatic range want to keep things in; sensor:detect given stimuli; Integrator:process and decision; Effector:respond and fix situation
Term
Nonpolar Covalent Bond
Definition
Electrons are shared and are equally distributed btw. the atoms.
Term
Examples of Nonpolar covalent bond
Definition
O_2, Lipid, CO_2
Term
Ribosomes
Definition
Come in 2 parts; produced in the nucleolus; rRNA-protein synthesis
Term
Vaults
Definition
Transport materials in/out of nucleus
Term
DNA Replication
Definition
Helicases:breaks hydrogen bonds in helix; DNA Polymerase:makes a polymer that attaches to each strand, makes complementary pairing; Semiconservative duplication: each is 2 sets-1parent/1 new daughter strand
Term
Cyclins
Definition
Chemicals that promote different phases of the cell cycle
Term
Cyclin D
Definition
promotes cell division (makes cells divide); to much/to fast-cancer
Term
Facilitated Diffusion
Definition
Need a carrier; requires no ATP; move from high to low; passive; specific-specialize to transport a specific solute; saturable-limited quantity of carriers; competitive-closely related compounds can complete for a given carrier
Term
Exocytosis
Definition
take out of cell
Term
Endocytosis
Definition
put into the cell
Term
Phagocytosis
Definition
cell pulls in; "eats"
Term
Pinocytosis
Definition
drinking
Term
Receptor Mediated
Definition
Receptors on outside take in solute, make vesicle, brings in and then reuses them
Term
Vesicular Transport
Definition
requires energy; movement of very large molecules-polar
Term
Active Transport
Definition
requires energy-ATP; move from high to low; Ex) Na/Kpump
Term
p53
Definition
tumor suppressor gene; inactivate cyclin D; control back up
Term
Golgi Apparatus
Definition
receives vesicles, identify, sorted, makes small transport vesicles to send to corresponding parts
Term
List the subatomic structures and their electrical charges
Definition
protons (+) electrons (-) neutrons
Term
What determines the atomic # of an element
Definition
# of protons in an atom
Term
Dehydration Synthesis
Definition
Remove H_2O, form bond
Term
Hydrolysis
Definition
Add H_2O, break bond
Term
Polymer of Amino Acids
Definition
Polypeptide (protein)
Term
Type of bonds in Amino Acids
Definition
peptide bond
Term
Polymers of Glycerol and Fatty Acids
Definition
Triglyceride
Term
Type of bond in Glycerol and Fatty acids
Definition
Ester bond
Term
Polymer of Glucose
Definition
Carbohydrate
Term
Type of bond in Glucose
Definition
Glycosidic
Term
Polymer of Nucleotides
Definition
DNA/RNA
Term
Hydrophilic
Definition
Molecules are soluable in water
Term
pH scale
Definition
Runs from 0-14; pH of 7 is neutral; pH of 8-14 is basic (alkaline); pH of 0-6 is acidic
Term
Cell Membrane
Definition
thin; divides living/non-living; selectively semi-permeable
Term
Nucleus
Definition
double membranous sac; 2 basic functions-genetic blue print for future generations, protein synthesis (control center)
Term
Cytoplasma
Definition
Everything inside cell, but the nucleus; organelles; cytosol-liquid portion; cytoskeleton-bones/muscle of cells, gives shape, movement
Term
rER
Definition
ribosomes on it; synthesizes proteins destined for secretion; synthesizes both proteins and phospholipids needed to build membrane structure; sends products to sER
Term
sER
Definition
no ribosomes; detoxification; store Ca; synthesizes lipids, phospholipids and steroids; takes materials from rER, packages, sends in transport vesicles to Golgi
Term
What determine the atomic mass of an element
Definition
the sum of the protons and neutrons in an atom
Term
What is an Isotope
Definition
same # of protons, but different # of neutrons; atomic # is the same, atomic mass is different
Term
Mitochondrion
Definition
double membranous sac; "power house"-generates greatest # of ATP from food; has own DNA
Term
Extrinsic Control
Definition
CNS and Endocrine-control the level of activity; maintain a balance throughout whole body; Extrinsic overrides intrinsic; principles of (-) and (+) feedback
Term
Basic functions of catalysts
Definition
Increase rate of a reaction; use over and over; doesn't change the nature of the reaction or the end product
Term
3subunits of a nucleotide
Definition
5 carbon (pentose) sugar; phosphate group attached to one end of the sugar; nitrogenous base attached to other end of sugar
Term
4 nitrogenous bases found in DNA
Definition
Adenine, Thymine, Guanine, Cytosine
Term
Lysosomes
Definition
membranous sacs that contain hydrolytic enzymes
Term
4 General Groups of Lipids
Definition
Phospholipids, Triglycerides, Prostaglandins, Steroids
Term
How are covalent bonds formed?
Definition
When atoms SHARE their valence electrons
Term
Ionic Bond
Definition
One or more valence electrons from one atom are completely transferred to a second atom
Term
Polar Covalent Bond
Definition
Unequally shared electrons btw. atoms
Term
Examples of Polar Covalent Bonds
Definition
Water, Glucose, Amino Acids
Term
Electrons
Definition
Capture and transfer energy
Term
What is a molecule
Definition
2 or more atoms joined together by a bond
Term
Plasma Membrane composition
Definition
Lipid Bilayer, Phospholipids, Cholesterol
Term
Pathological cell death
Definition
Natural, happens (no blood), swells and ruptures
Term
Apototsis (cell death)
Definition
programed death
Term
Interphase
Definition
Nucleus is visible; G1-growth and differentiation; restriction pt.; S-DNA duplicates; G2-growth and differentiation and organelles duplicate
Term
Membrane Proteins
Definition
Channels, Carriers, Receptors, Enzymes
Term
Channels
Definition
hollow, water filled tunnel; ions go through; chem./electrically/mechanically controlled; specific
Term
Carriers
Definition
transport substance through that can't get in on own; specific
Term
Receptors
Definition
have a binding site (outer surface); recognize/bind specific molecule
Term
Enzymes
Definition
control specific chem. reactions on outside/inside surface
Term
Membrane
Definition
non-polar; non-polar molecules move through by simple diffusion; driven by concentration gradient
Ex) Fats, O_2, CO_2
Term
Charged Ions
Definition
Facilitated; channels
Term
Polars
Definition
needs ATP; facilitated diffusion
Term
Anaphase
Definition
sister chromatids are pullen apart; chromosomes move to opposite ends of cell
Term
Telophase
Definition
Chromosomes disappear; nucleolus and nuclear envelop reappear; fibers gone; cleavage furrow
Term
Cytokinesis
Definition
Division of cytoplasm into 2 daughter cells
Term
3 types of RNA
Definition
mRNA, rRNA, tRNA
Term
Transcription
Definition
process of rewriting DNA; takes DNA template, rewrites into mRNA, exits nucleus to cytosol
Term
Translation
Definition
takes 3 letter words (codon) and translates into Amino Acids
Term
Start codon
Definition
AUG
Term
Stop codons
Definition
UAG, UAA, UGA
Term
Primary Structure
Definition
peptide bonds
Term
Secondary Structure
Definition
hydrogen, peptide
Term
Tertiary Structure
Definition
hydrogen, disulfide, peptide
Term
Quaternary structure
Definition
hydrogen, disulfide, peptide
Term
Physiology
Definition
the study of how the body works
Term
8 cellular functions necessary for life
Definition
1) Cell has to obtain nutrients/O_2 from surrounding environment
2) Perform chemical reactions
3) Excretion
4) Protein synthesis
5) Responsiveness
6) Control exchange of materials btw. the cell and surrounding environment
7) Movement
8) Reproduce
Term
4 basic types of tissue
Definition
Nervous tissue, Epithelial Tissue, Muscle tissue, Connective tissue
Term
Intracellular Fluid
Definition
fluid inside the cell
Term
Extracellular Fluid
Definition
fluid outside the cell
Term
Plasma
Definition
extracellular fluid; liquid part of blood
Term
Interstital Fluid
Definition
Around the outside of cells; fluid in the tissue btw. the cell
Term
Homeostatsis
Definition
Maintenance of a relatively stable environment for the cell in order for that cell to function/survive
Term
4 Functions of a Protein
Definition
Channels, Enzymes, Receptors, Carriers
Term
3 types of RNA
Definition
mRNA, rRNA, tRNA
Term
mRNA
Definition
carries the genetic code into the cytoplasm where protein synthesis occurs
Term
rRNA
Definition
decodes mRNA into various amino acids and assisting in trasnlation
Term
tRNA
Definition
transporting specific amino acids to the ribosome to be added onto the growing polypeptide chain
Term
Membrane Carbohydrates
Definition
cell identity and recognition
Term
Hydrophobic
Definition
molecules are insoluable in water
Term
6 homeostatically regulated factors
Definition
1)Concentration of nutrients and O_2
2)Concentration of waste products
3)Concentration of salts and electrolytes
4)Acid/Base balance
5)Temperature
6)Volume and pressure
Term
Aerobic Respiration
Definition
O_2 is present
Term
Anaerobic Respiration
Definition
No O_2 is present
Term
Hypertonic
Definition
Water came out; going to shrivel/crenate
Term
Hypotonic
Definition
Water moves in; going to swell/lysis
Term
Isosmotic
Definition
both have the same # of solute particles
Term
Glycolysis
Definition
Conditions: Aerobic and Anaerobic
Location: Cytosol
Products: 2 Pyruvic Acid, Net of 2 ATP, 2NADH, 2Water, by product of lactic acid
Term
Acetyl formation
Definition
Conditions: Aerobic
Location: Mitochondrial Matrix
Products: Acetyl CoA, CO_2, NADH (2x's)
Term
Kreb Cycle
Definition
Conditions: Aerobic
Location: Mitochondrial matrix
Products: 2 CO_2, 3NADH, 1FADH_2, 1ATP (2x's/glucose)
Term
Electron Transport Chain
Definition
Conditions: Aerobic
Location: Mitochondrial Matrix, Inner Mitochondrial membrane, Intermembranous space
Products: 26 ATP, Water
Term
Positive Feedback
Definition
antibody production, blood clot, uterine contraction during child birth
Term
Intrinsic control
Definition
An organ has some control over it's own level of activity; Accomplished by local neural mechanisms or local hormones
Term
Hypoosmotic
Definition
decrease # of solute
Term
10 systems that contribute to homeostasis
Definition
Circulatory, Respiratory, Digestive, Skeletal, Muscular, Integumentary (skin), Urinary, Endocrine, Nervous, Immune
Term
1 system that does not help contribute to homeostasis
Definition
Reproductive
Term
Control of Enzymatic activity
Definition
By temp. and pH of solution; concentration of cofactors and coenzymes; concentration of enzymes and substrate molecules; stimulation and inhibitory effects of products on enzyme activity
Term
Endergonic Reactions
Definition
Require an input of energy
Term
Exergonic reactions
Definition
output (energy released); product less than reactions
Term
Energy carriers
Definition
ATP, NAD, FAD
Term
Equilibrium
Definition
No longer a gradient
Term
Fick's Law of Diffusion: Diffusion directly related to
Definition
Concentration gradient, Surface area, Permeability of membrane, Temperature
Term
Fick's Law of Diffusion: Diffusion inversely related to
Definition
Size, Distance, Membrane thickness
Term
Osmosis
Definition
Movement of water to an area of higher solute concentration
Term
Isotonic
Definition
No net water movement; 0.9% NaCl, 5% Dextrose, 300 mOs
Term
Peroxisomes
Definition
Small membranous sacs-oxidative enzymes; some detoxification
Term
Prophase
Definition
DNA becomes visible, because chromatin fiber coils around histone; Nucleolus/Nuclear envelop disappear; Centrioles migrate to opposite end of cell; Spindle fibers develop off centrioles and attach to centromere
Term
Metaphase
Definition
All chromosomes line up in the middle
Term
Hyperosmotic
Definition
increase # of solute
Term
Amphipathic Molecule
Definition
head- polar, tail- non polar; Membrane behaves as a non polar due to the hydrophobic region made by the fatty acid chains
Term
Desmosomes
Definition
"spot welds"; Protein filaments tie cells together (not touching); strong/stretchy; Permeable
Term
Tight Junctions
Definition
impermeable junctions; proteins tie membranes together (nothing moves through); highly selective; strong sheets
Term
Gap junctions
Definition
communicating junctions; 2 cells that don't touch; hollow proteins in wall makes hollow tunnel, can move ions rapidly w/out barriers
Term
Diffusion
Definition
random passive movement down a gradient from high to low concentration
Term
Electrical Gradient
Definition
Simple diffusion; Separation of charges; (+) pull (-) one way and vise versa
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