Term
|
Definition
| remove as much of tumor as possiblevia surgery, making chemo and radiation more effective |
|
|
Term
|
Definition
| radiation therapy, markings placed on skin to calibrate radiation machine |
|
|
Term
| whats worse? Dry or Wet desquamation |
|
Definition
| Wet. Sloughing of skin. Keep area clean and protected and avoid constricting clothes |
|
|
Term
| When and Why does fatigue result during radiation? |
|
Definition
| 3-4 weeks. Result of accumulation of metabolites from cellular destruction. Walking program intervention. EBP |
|
|
Term
| Factors that determine chemotherapy response |
|
Definition
| location, mitotic rate, size and age of tumor. more rapid = better response smaller = better response younger = greater response |
|
|
Term
| Which drug(s) are cell cycle non specific? |
|
Definition
| Cyclophosphaminde (Cytoxan) & Doxorubicin(Adriamycin) |
|
|
Term
| Which drug(s) are cell cycle specific? |
|
Definition
| Fluorouracil (5FU) & Vincristine (Oncovin) |
|
|
Term
| What class is Cyclophosphamide (Cytotoxan)? |
|
Definition
| Alkylating agent. May cause a 2nd malignancy. cell cycle non specific |
|
|
Term
| What class is Flourouracil (5FU)? |
|
Definition
| Antimetabolite. Cell Cycle specific and works on the S phase. |
|
|
Term
| What class is Doxorubicin (Adriamycin)? |
|
Definition
| Antitumor antibiotic. Cell Cycle non specific |
|
|
Term
| What class is Vincristine (oncovin)? |
|
Definition
| Mitotic inhibitor. Cell cycle specific and works on the M phase. |
|
|
Term
| What are the side effects of Cyclophosphamide (Cytotoxan)? |
|
Definition
| hemorrhagic cystitis N&V, myelosuppression, alopecia & hemorrhagic cystitis - permanent bladder destruction. |
|
|
Term
| What are the side effects of Flourouracil (5FU)? |
|
Definition
stomatitis, diarrhea, N&V, myelosuppression, hyperpigmentation, hand-foot syndrome.
stomatitis - mouth sores |
|
|
Term
| What are the side effects of Doxorubicin (Adriamycin)? |
|
Definition
Cariac toxicity, vesicant, myelosuppression, alopecia, N&V.
Cardiac toxicity - remember ejection fraction |
|
|
Term
| What are the side effects of Vincristine (oncovin)? |
|
Definition
Neurotoxicities, constipation, Vesicant, parasthesia, foot drop, mild myelosuppression.
VinCristiNe (vessicant,constipation,neurotoxicity) |
|
|
Term
| What are nursing implications for Cyclophosphamide (Cytotoxan)? |
|
Definition
| Increase fluid intake, give early in the day, void frequently. |
|
|
Term
| What are nursing implications for Flourouracil (5FU)? |
|
Definition
| monitor mouth and bowel patterns, keep out of the sun, use sunscreen. |
|
|
Term
| What are nursing implications for Doxorubicin (Adriamycin)? |
|
Definition
| Need ejection fractions before given, first void will have pink urine due to red nature of drug. Also - vesicant. |
|
|
Term
| What are nursing implications for Vincristine (oncovin)? |
|
Definition
| Need bowel protocol (monitor constipation), Assess for peripheral neuropathy symptoms. Also- vesicant. |
|
|
Term
| Why is chemotherapy given through a central line? |
|
Definition
| Because Vesicant drugs can destroy tissues if they get out of the vessel. |
|
|
Term
|
Definition
| boosting the immune system to better deal with cancer. |
|
|
Term
| What two types of biotherapy are there? |
|
Definition
| Alpha interferon & Interleukin - Aldesleukin (Proleukin) |
|
|
Term
| What are side effects of biotherapy? |
|
Definition
| flu-like effects. Acetaminophen before tx and q4h after tx. IV meperidine (demerol) to control severe chills, Vital signs, rest, adequate oral intake. |
|
|
Term
| What is targeted therapy? |
|
Definition
| Interferes w/ CA growth by targeting specific cellular receptors and pathways important for tumor growth. Able to kill tumor cells w/ less dmg. to normal cells. |
|
|
Term
| Rituximab (Rituxin) function |
|
Definition
| bind to CD 20; used with non-Hodgkin's lymphoma. Caoable of binding to target cells and destroying them. (TARGETED THERAPY) |
|
|
Term
| Rituximab (Rituxin) side-effects |
|
Definition
| flu like sx, BM suppression, fatigue, cardiotoxicity, hepatotoxicity, diarrhea, risk of anaphylaxis |
|
|
Term
|
Definition
| Beta-Blockers- Check BP and HR. Hold <60 HR. 'olol SE: Bradycardia, Hypotension |
|
|
Term
| Class III Antidysrhythmic |
|
Definition
| Potassium Channel Blockers- Amiodarone, Sotalol |
|
|
Term
|
Definition
| Calcium Channel Blockers - Diltiazam - Decreases HR and BP. SE: Bradycardia, Hypotension |
|
|
Term
|
Definition
| Used to treat TACHYCARDIA, slows down the SA node |
|
|
Term
|
Definition
| Used to treat BRADYCARDIA, speeds up the heart! SE: dilation of the pupils |
|
|
Term
| 5 lead EKG (rhythm strip) |
|
Definition
| Just to show electro activity in the heart. |
|
|
Term
|
Definition
| ischemia or infarction? electrolyte imbalances? irregular positioning of heart? |
|
|
Term
|
Definition
|
|
Term
| How many small boxes in one large box in an EKG? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Angiogenesis inhibitor function |
|
Definition
| VEGF- binds to vascular endothelial growth factor. VEGF |
|
|
Term
| Angiogenesis inhibitor side effects |
|
Definition
| HTN, colon bleeding & perforation, impaired wound healing, thromboembolism, hemorrhage. ALL BLEEDING RELATED STUFF |
|
|
Term
| What does Trastuzumab (Herceptin) do? |
|
Definition
| Binds to HER-2 & inhibits growth of breast cancer cells that overexpress the HER-2 protein. |
|
|
Term
| What herbs can interfere with CA treatment? |
|
Definition
| St. John's Wart, garlic, Echinacea |
|
|
Term
| Class IA,IB,IC Antidysrithmics |
|
Definition
| Sodium Channel Blockers Lidocaine, Procainimide, Quinidine |
|
|
Term
| How long is one large box on an EKG strip? |
|
Definition
|
|
Term
| What does the P wave represent? |
|
Definition
|
|
Term
| What does the P wave represent? |
|
Definition
|
|
Term
| What does the QRS complex represent? |
|
Definition
| Ventricular depolarization |
|
|
Term
| What does the T wave represent? |
|
Definition
| Ventricular repolarization |
|
|
Term
|
Definition
0.12 - 0.20 seconds
(3-5 small boxes) |
|
|
Term
|
Definition
Less than or equal to .11 seconds
(<3 small boxes) |
|
|
Term
|
Definition
| .12 seconds (3 little boxes) |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| How do you treat symptomatic bradycardia? |
|
Definition
|
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