Shared Flashcard Set

Details

Estrogens and Progestins
Pharm 2 Exam 4
54
Health Care
Graduate
04/13/2009

Additional Health Care Flashcards

 


 

Cards

Term
Oral Estrogens
Definition

conj equine

conj synthetic

estradiol

ethinyl estradiol

Term
transdermal estrogen
Definition
estradiol
Term
tx uses of estrogens
Definition

menopausal hormone replacement

prevention of post-menopausal osteoporosis

Term
AE estrogens
Definition

endometrial hyperplasia -> CA's

CV events

promote growth of CA w/ estrogen receptors

Term
Oral progestins
Definition

medroxyprogesterone acetate

norethindrone acetate

megesterol acetate

Microionized form

Term
IM progestins
Definition

medroxyprogesterone acetate

progesterone

Term
intravaginal progestin
Definition
progesterone gel
Term
transdermal progestin
Definition

norethindrone (+ estradiol)

lebonorgestrel (+ estradiol)

Term
tx uses progestins
Definition

post-menopausal hormone tx

dysfunctinoal uterine bleeding

amenorrhea

Term
how does progestin help dysfunctional uterine bleeding
Definition
balancing influence of estrogen on the endometrium
Term
Estrogen/progestin combo
Definition
conjugated estrogens/medroxyprogesterone acetate
Term

Selective Estrogen Receptor Modulators

(SERMS)

Definition

Tamoxifen

Raloxifene

Toremifene

Fulvestsrant

Term
which SERM shows no increased risk of endometrial CA
Definition
Raloxifene
Term
which SERM shows fewer cases of blood clotting
Definition
Raloxifene
Term
which SERM shows NO risk of endometrial CA
Definition
Fulvestrant
Term
which SERM is IM only
Definition
fulvestrant
Term
MOA SERMS
Definition
activate estrogen receptors in SOME tissues and BLOCK them in others
Term
tx uses of SERMS
Definition

benefits estrogen w/o risks

inhibit breast tissue growth

incr bone mineral density

decr LDL and incr HDL

Term
AE SERMS
Definition

hot flashes

fluid retention

vag discharge

N/V

menstrual irregularities

endometrial CA

Term
SERMS ___ LDL and ___ HDL
Definition
DECREASE LDL, INCREASE HDL
Term
SERMS are used in the tx and prevention of
Definition
breast CA
Term
Oral contraceptives
Definition

combo E&P

progestin only

 

Term
progestin pills are aka
Definition
"mini pills"
Term
what 2 estrogens are used in OCP's
Definition

ethinyl estradiol

mestranol (converts to ethinyl estradiol in body)

Term
what is the most common progestin used in OCP's
Definition
norethindrone
Term
OCP's w/ constant doses throughout cycle
Definition
monophasic
Term
OCP where estrogen is constant and progestin incr over 2nd half of cylce
Definition
biphasic
Term
OCP where doses are divided into 3 phases where progestin levels change.  also estrogen may vary too
Definition
triphasic
Term
MOA OCP's
Definition

inhibit ovulation

thicken cervical mucous

modify endometrium (less favorable implant)

Term
non-contraceptive tx uses of OCP's
Definition

decr risk endometrial, ovarian CA/ cysts

PID, PMS, TSS, anemia, acne

decr cramps

lighter shorter period (more predictable)

Term
AE OCP's
Definition

thromboembolic d/o

HTN

CA (protect some, incr risk others)

abn. uterine bleeding

benign hepatic adenoma

mult births

glucose intolerance

gallballder dz

melanoderma

acne, hirsuitism, hair loss

Term
excess estrogen signs
Definition

N

breast tenderness

edema

Term
excess progestin sx
Definition

increased appetite

fatigue

depression

Term
CI/interactions of OCP's
Definition

obesity (decr)

NO PREGO

Term
what drugs reduce OCP effectiveness
Definition

rifampin

carbamazepine

phenobarb

phenytoin

 st. johns wort

(P450 inducers)

antibiotics that decr enterohep cycling

Term
OCP's reduce effects of
Definition

warfarin

hypoglycemic agents

 

Term
OCP's incr effect of
Definition

theophylline

imipramine

(impairs hepatic met)

Term
yasmin contains
Definition

EE and drospirenone

 

*reduce fluid retention

Term
what is the major concern of yasmin
Definition
hyperkalemia
Term
patch composition
Definition

EE and norelgestromin

 

levels plateau day 2

 

> E than OCPs

Term
AE patch
Definition

HA

skin irritation

N

cramping

Term
Vag ring comp
Definition
EE, etonogestrel
Term
AE vag ring
Definition

vaginitis

HA

wt. gain

N

thrombosis

HTN

embolism

Term
MOA progestin only
Definition

alter cervical excretions

endometrium less favorable for implant

Term
AE progestin only
Definition

irregularity/spotting

amenorrhea

inconsistent cycles

Term
do progestin only meds cause thromboembolic d/o?
Definition
NO
Term
what to do w/ missed dose of progestin only
Definition

1 x: take ASAP

2 x: asap, discard other

3 x: d/x until menstruations -> r/o prego

Term
long-acting contraceptives
Definition

implant

depo medroxyprogesterone acetate

Term
implant MOA
Definition

inhibit ovulations by preventing mid-cycle lutenizing homrone peak

 

changes in cervical mucous

Term
most effective form contraceptive
Definition
implant
Term
onset of implant
Definition

w/i 8 hrs

peaks 4 days-> steady

Term
AE implant
Definition

menstrual irregularities

prolonged bleeding

spotting

breast d/c

cervicitis/vaginitis

Term
depot AE
Definition
bone loss
Term
what dose for estrogen to start out
Definition
35 mcg or <
Supporting users have an ad free experience!