Term
|
Definition
|
|
Term
| [(SFD/V)/ (1-e^/kT)](e^-kt) |
|
Definition
|
|
Term
|
Definition
| D and T unchanged; 3-5 half lives elapsed |
|
|
Term
|
Definition
| D and T changed or 3-5 half lives have not elapsed |
|
|
Term
|
Definition
| Confounding factors; complex equations; difficult PK workup |
|
|
Term
| T < or = 1/2 the half life |
|
Definition
|
|
Term
|
Definition
|
|
Term
| tin< 1/6 of the half life |
|
Definition
| IVB ( (SFD/V)/1-e^-kT) (e^-kt) ) |
|
|
Term
| tin > or equal to 1/6 of the half life |
|
Definition
| Short infusion ( (SFD/tin)/(1-e-kT) (1-e-ktine)(e-kt) ) |
|
|
Term
|
Definition
| Intermittent IV bolus model |
|
|
Term
|
Definition
|
|
Term
| Therapeutic range of Digoxin for CHF |
|
Definition
|
|
Term
| Digoxin confounding factors: |
|
Definition
| hypokalemia, hypercalcemia, Cor Pulmonale --> AF, LSHF, Afib (may be able to tolerate higher doses) |
|
|
Term
| bioavailability: digoxin tablet |
|
Definition
|
|
Term
| bioavailability: digoxin gel caps |
|
Definition
|
|
Term
| bioavailability: digoxin elixer |
|
Definition
|
|
Term
| bioavailability effect on digoxin with St. John's Wort |
|
Definition
| decreased; p-glycoprotein |
|
|
Term
| bioavailability effect on digoxin with antibiotics |
|
Definition
| increased; eubacterium lenum (metabolizes digoxin but is wiped out by abx) |
|
|
Term
|
Definition
|
|
Term
| Digoxin volume of distribution with renal failure |
|
Definition
|
|
Term
| Digoxin volume of distribution with hypothyroidism |
|
Definition
|
|
Term
| digoxin volume of distribution with hyperthyroidism |
|
Definition
|
|
Term
| digoxin volume of distribution with quinidine |
|
Definition
|
|
Term
| clearance with hypothyroid |
|
Definition
|
|
Term
| clearance with hyperthyroid |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Clearance eq. without CHF |
|
Definition
| (0.8 m/kg/min) (wt) + renal creatnine clearance |
|
|
Term
|
Definition
| (0.3 ml/kg.min) (wt) + (0.9) (renal creatnine clearance) |
|
|
