Term
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Definition
| thickened keratin layer of the surface epithelium |
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Term
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Definition
| there is no granular cell layer and the epithelial nuclei are retained in the keratin layer. |
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Term
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Definition
| intercellular edema of the spinous layer |
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Term
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Definition
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Term
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Definition
| alteration in size, shape, and organization of adult cells. Usually begins in the basilar portions of the epithelium. |
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Term
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Definition
| a type of papillary, exophytic proliferation of squamous epithelium. Usually seen in smokeless tobacco |
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Term
leukoedema
clinical features |
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Definition
*white bluish tinge of the buccal mucosa
*painless and persistent
*more common in blacks and dark skinned caucasians
*not a neoplasm but a normal variation
**white appearance disappears when tissue is stretched (differentiates from leukoplakia) |
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Term
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Definition
*white line along buccal mucosa in region of occlusal plane
*5-13% of all patients
*due to biting cheeks
*differentiate from moricatio buccarum |
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Term
squamous papilloma
clinical feat |
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Definition
*COMMON oral lesion
*exophytic, "cauliflower" like soft lesion
*1/3 found of soft palate or uvula. |
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Term
Squamous papilloma
Histology |
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Definition
long thin finger like projection of squamous epithelium containing a thin connective tissue core
*may show hyperkeratosis |
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Term
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Definition
| excisional biopsy (including base of lesion), vaccine targeted for HPV tyes 6, 11, 16, and 18 |
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Term
verrucous vulgaris
clinical features |
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Definition
common painless persistent
wart-like with sessile base
FINGER LIKE PROJECTION (which always comes down to a squamos core)
white or normal color
can be clinically identical to papilloma |
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Term
verrucous vulgaris
histology |
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Definition
pointed projections from the surface wpithelium
thickened keratin
viral inclusions may be seen in upper spinous layer
inflammation in connective tissue |
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Term
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Definition
ranges from dysplasia to carcinoma in situ
HPV subtypes 16, 18 |
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Term
condyloma acuminatum
vs
squamous papilloma |
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Definition
condyloma acuminatum grows faster and gets larger- much faster proliferation
CM is mainly due to HPV 6, 11
incubation period for CM is 1-3 months |
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Term
condyloma acuminatum
clinical features |
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Definition
sexually transmissible and autoinoculable viral disease (STD)
may occur 1-3 months after contact
soft papillary nodules that proliferate rapidly in size
most common in anogenital skin
if in mouth:
*multiple papillary masses involving tongue, buccal mucosa, palate, gingiva
*white or pink
*up to 2cm in diameter
**in anogenital area, HPV 16 &18 are associated with increse in squamous carcinoma |
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Term
Focal Hyperplasia (Heck's Disease)
Clinical Features |
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Definition
painless and persistent
ist observed in american indians
flattened multiple nodular lesions usually on lower lip (also on commissures, buccal mucosa, upper lip and tongue)
lesions usually 1-5mm diameter
same color as adjacent mucosa
may undergo spontaneous regression after 4-6mo or years |
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Term
Focal Hyperplasia
Histology |
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Definition
ancanthosis
mitosoid cells are simetimes seen in squamous epithelium |
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Term
verruciform xanthoma
clinical features |
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Definition
lipid laden histocytes beneath epithelium
uncommon, painless, persistent
usually solitary lesion up to 1.5cm diameter
sessile or pedunculated base
ROUGH or PEBBLY surface |
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Term
Verruciform xanthoma
HISTOLOGY |
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Definition
verrucous hyperparakeratotic surface with elongated rete ridges
LARGE SWOLLEN FOAM CELLS (HISTOCYTES AND XANTHOMA CELLS) in connective tissue papillae between peithelial pegs |
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Term
keratoacanthoma (self-healing carcinoma)
clinical features |
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Definition
*self healing benign lesion that clinically resembles squamous cell carcinoma
usually on sun exposed skin
may be: solitary or multiple, painful
3 growth phases: growth, static, involution |
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Term
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Definition
| abnormal keratin production |
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Term
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Definition
| abnormal keratin production |
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Term
white spongus nevus
clinical features |
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Definition
autosomal dominant transmitted condition.
due to defect of normal keratinization
mucosa appears thickened and corrugated with sponge texture
usually involves buccal mucosa (also palate, gingiva,floor of mouth, and tongue)
childhood onset
often mistaken for leukoplakia |
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Term
white sponge nevus
histology |
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Definition
acanthosis and hyperparakeratosis
intracellular edema on surface |
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Term
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Definition
white patch on the mucosa that will not wipe off and is no other specific disease
ONLY A CLINICAL TERM |
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Term
| frictional (focal) keratosis |
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Definition
non cancerous
similar to callus on skin |
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Term
leukoplakia
clinical features |
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Definition
premalignant lesion
older population
varies: small localized area to large diffuse lesion (multifocal)
vary from non palpable faintly white to leathery areas
most common sites are BUCCAL MUCOSA AND MANDIBULAR ALVEOLAR MUCOSA
80% are smokers |
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Term
| clinical types of leukoplakia |
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Definition
mild or thin
homogenous or thick
granular or nodular-bad
verrucous or verruciform-bad |
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Term
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Definition
acanthosis, hyperkeratosis and hyperparakeratosis
possibly some mild inflammation
***may become dysplastic,invasive without any change in clinical appearance. |
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