What does H&E stand for?

and what does it bind.

Hematoxylin & Eosin

Hematoxylin binds acidic structures such the DNA in the nucleus

Eosin binds proteins such the ones present in the cytoplasm

1. Tight junctions, zona occludens to seal off basal side form the apical side.

2. Pumps to create agradient

Replacement of normal epithelial tissue

with connective tissue in an organ

is called _________

Fibroblasts
Adipocytes
Macrophages
Mast cells
Plasma cells
Lymphocytes
Neutrophils

Eosinophils

True or False

Connective tissue cells require a basal membrane to replicate

True or False

The most important feature of macrophages is that they are signaling molecules

True or False

Macrophages are found in ALL connective tissue

Store and release substances that mediate inflammatory response

Examples: histamine, heparin, leukotrienes

Where are plasma cells derived from?

What is their function?

Derived from B lymphocites

Function: release antibodies.

True or false

Usually neutrophils and eosinophils are found in connective tissue

False

They are usually found in blood and are only found in connective tissue at sites where infection is present or at sites where there is an inflammatory event.

Collagen fibers (collagen I)

Reticular fibers (collagen III)

Elastic fibers

Arrange in order:

Biggest structure to smallest structure:

tendon, fibril, fiber,

bundle, alpha chain,

tropocollagen molecule

Name some locations for

Type I collagen

Where do you find

Elastic fibers

larynx

skin

trachea

bronchi

arteries

Responsible for CT's ability to:

Store electrolytes and water

Resist compression

Form viscous barrier

Attachment and movement of cells in ECM

Where does ground substance come from?

What does it consists of?

Secreted by fibroblasts.

Consists of proteins and carbohydrates

or to be more specific:

Glycoconjugates and Tissue fluids

Repair by connective tissue features

inflammation

angiogenesis

mirgration and proliferation of fibroblasts

scar formation

connective tissue remodeling

OR

Inflammarion, Proliferation, Maturation

neutrophils initialte response

clot formation begins

3 to 7 days after the injury

"proliferation" stage

At what stage of the wound healing response is granulation tissue formed?

Ahat is a characteristic histologic feature of granulation tissue?

Proliferation stage (3 to 7 days after injury)

Presence of small new vessels (angiogenesis)

At what stage of wound healing does collagen deposition happen?

Where do you find

simple cuboidal epithelium

Where do you find

non-ciliated simple columnar epithelium

where do you find

ciliated simple columnar epithelium

lining of bronchioles of respiratory tract,

uterine tubes, uterus,

paranasal sinuses,

central canal of spinal cord,

ventricles of brain

where do you find

pseudostratified epithelium

lining of airways of upper respiratory tract

larger ducts of many glands,

epididymis, parts male urethra

Where do you find

stratified squamous epithelium?

superficial layers of skin

wet surfaces

Where do you find

stratified cuboidal epithelium

ducts of adult sweat glands

esophageal glands,

male urethra

where do you find

Stratified columnar epithelium

lining part of urethra,

large excretory ducts of some glands

anal mucous membrane

part of eye

where do you find

transitional epithelium

lines urinary bladder

portions of ureters and urethra

Where do you normally find

stem cells and transit amplifying cells

alteration of adult tissue that makes a change in 

type, or distribution

of cells normally expressed.

Often involves alteration of progenitor cells or stem cells

Alteration in adult tissue that makes a change in

the type or distribution of normal cells but

it is associated with a disease

- Loose

- Dense (regular and irregular)

Fibroblasts

Adipocytes

reticular cells

melanocytes

pericytes

Macrophages

plasma cells

mast cells

lymphocytes

leukocytes

Store electrolytes and water,

resist compression

form viscous barrier

attachment and movement of cells in ECM

host defense peptides.

They are active against viruses, bacteria and fungus