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Epilepsy Drugs
FA pg 473
12
Pharmacology
Graduate
02/18/2013

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Cards

Term
phenytoin
Definition
tonic-clonic. status epilepticus prophylaxis. increase Na+ inactivation.
SLE-like syndrome. neuro symptoms. gingival hyperplasia. hirsutism. megaloblastic anemia. teratogen. P450.
Term
Carbamazepine
Definition
simple. complex. tonic-clonic. trigeminal neuralgia. increase Na+ inactivation.
neuro symptoms. agranulocytosis. aplastic anemia. liver probs. teratogen. P450. SIADH. Stevens Johnson syndrome.
Term
lamotrigine
Definition
blocks voltage gated Na+ channels.
Stevens Johnson syndrome.
Term
Gabapentin
Definition
inhibits HVA Ca2+ channels.
Sedation. Ataxia.
Term
Topiramate
Definition
blocks Na+ channels. increase GABA action.
sedation. kidney stones. weight loss.
Term
Topiramate
Definition
blocks Na+ channels. increase GABA action.
sedation. kidney stones. weight loss.
Term
phenobarbital
Definition
increase GABA action. first line for pregnant and kids.
sedation.
Term
Valproic acid
Definition
tonic-clonic. increase Na+ inactivation, increase GABA concentration.
GI distress. hepatotoxicity. neural tube defects in fetus. tremor. weight gain.
Term
Ethosuximide
Definition
absence seizures. blocks thalamic T-type Ca2+ channels.
GI distress. headache. urticaria. Stevens Johnson syndrome.
Term
Benzodiazepines
Definition
acute status epilepticus. increase GABA action.
sedation.
Term
tiagabine
Definition
inhibits GABA reuptake.
Term
Vigabatran
Definition
irreversibly inhibits GABA transaminase which increases GABA
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