Term
| Phenytoin a strong inducer or inhibitor? |
|
Definition
|
|
Term
| Does Phenytoin lower the concentration of other drugs? |
|
Definition
Yes; other anticonvulsants - carbamazepine, valproate, lamotrigine, as well as birth control pills.
|
|
|
Term
| Describe Phenytoin'st binding? |
|
Definition
High protein binding (90 - 95 %); it can displace other highly - protein bound drugs, and others can displace phenytoin, causing an increase in drug levels and potential toxicity.
|
|
|
Term
| DescribeIV phenytoin preperations? |
|
Definition
IV phenytoin can only be mixed with NS.
|
|
|
Term
| Describe fosphenytoin IV preperation? |
|
Definition
| fosphenytoin can use NS or D5W? |
|
|
Term
| Can phenytoin be given with tube feedings? |
|
Definition
No. Do not give with tube feeds. Hold tube feeds 2 hrs prior and 2 hrs after dosing. Calcium supplements should also be given at separate times. |
|
|
Term
| Use special caution with combination of valproate and lamotrigine due to what? |
|
Definition
serious risk of rash (combo is used in children, requires slow titration and parent counseling).
|
|
|
Term
| Carbamazepine a strong inducer or inhibitor? |
|
Definition
Carbamazepine is a strong 3A4 inducer and auto inducer.
It will decrease the levels of many drugs & including oral contraceptions. |
|
|
Term
| Carbamazepine is what kind of substrate? |
|
Definition
|
|
Term
| Is carbamazepine better or worse than oxcarbazepine in terms of side effects? |
|
Definition
Less drug interactions than carbamazepine
|
|
|
Term
| Oral contraceptions regarding oxcarbazepine and carbamazepine? |
|
Definition
Significant decreasing of oral contraceptivies with either carbamazepine and oxcarbazepine.
|
|
|
Term
| What anticonvulsant increases lamotrigine? |
|
Definition
|
|
Term
| What decreases levels of lamotrigine? |
|
Definition
| penytoin, phenobarbital, primidine, carbamazepine |
|
|
Term
| Phenobarbital/Primidine are inducers or inhibitors? |
|
Definition
Phenobarbital (primidone is the pro-drug) is a strong inducer of most CYP enzymes, including 3A4. These two drugs will lower the levels of many drugs that are hepatically metabolized. |
|
|
Term
| Name Levetiracetam's significant drug - drug interactions. |
|
Definition
| No significant drug interactions! |
|
|
Term
| Is Felbamate comonly used? |
|
Definition
No. If it being used in a case, there is likely a reason why it should not be used. This drug is used by nerologists only for reactive caues. |
|
|
