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Epidemiology Intro
Revision
34
Medical
Undergraduate 2
04/14/2012

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Term
Epidemiology
Definition
The study of the determinants and distribution of health related states or events in specified populations and the application of this study to the prevention and control of health problems
Term
Sufficient
Definition
Presence of this factor is enough to result in disease
Term
Necessary
Definition
Disease is never present when factor is not present.
Term
Factors in causation
Definition
+ Pre-disposing
+ Enabling
+ Precipitating
+ Re-inforcing
Term
Attribution fraction
Definition
The likely preventative impact of eliminating a specific causal factor. (Re-Ru)/Re x 100%
Term
Bradford-Hill Causation model
Definition
+Temporal relationship (necessary)
+ Plausibility
+ Reliability
+ Strength of study design
+ Consistency
+ Strength of association
+ Dose-response
+ Reversibility
Term
WHO definition of Health
Definition
Health is a state of complete mental, social and physical well-being and not merely the absence of disease or infirmity.
Term
Incidence
Definition
Rate of new cases of disease over a given time in a specified population
Term
Prevalence
Definition
Frequency of existing cases of a disease in a defined population at a given point in time.
Term
Case fatality
Definition
Number of deaths per total number of cases in a given period of time.
Term
Risk ratio / Relative risk
Definition
Risk in exposed / Risk in unexposed. For cohort and RCT.
Term
Risk difference/ Attributable risk
Definition
Risk in exposed - risk in unexposed
Term
Population Attributable Risk
Definition
% of disease in the whole population that can be attributed to a particular exposure. Rt-Ru (or for percentage: (Rt-Ru)/Rt x 100%)
Term
Odds Ratio
Definition
Compares the odds of exposure in cases vs. controls. OR = ad/bc. For case-control and cross-sectional studies.
Term
Random error
Definition
Due to chance alone. Includes sampling errors and measurement errors.
Term
Systematic error
Definition
Where results differ from true values. Includes selection bias, measurement bias + recall bias.
Term
4 Potential errors in epidemiological studies
Definition
+ Random (sampling, measurement)
+ Systematic (recall, measurement, selection)
+ Sample size
+ Confounding
Term
Control of confounding factors
Definition
+ Design stage: Randomisation, restriction & matching
+ Analysis stage: Stratification, statistical modelling
Term
Reliability
Definition
Stability (consistent answers) and reproducibility over time.
Term
Validity
Definition
Is test capable of measuring what it is intended to measure? Internal validity is whether results are correct for the group being studied and external validity is how these results apply to those not in the study.
Term
Descriptive study
Definition
Observational study which routinely collects data and makes no link between exposure and outcome.
Term
Ecological study
Definition
Observational study that is hypothesis generating and where the unit of measurement is a population rather than individuals.
Term
Cross-sectional study
Definition
Observational study where exposure and outcome are measured at one point in time. OR
Term
Case-control study
Definition
Observational study which compares cases (disease) with controls (no disease). OR
Term
Cohort study
Definition
Observational study which compares exposed and unexposed and follows them in time to observe outcomes of disease. May be prospective or retrospective. RR
Term
Randomised control trial
Definition
Experimental study which compares outcomes of treatment groups allocated randomly and often blinded. Must be approved by an ethics committee. RR
Term
Meta-analysis
Definition
Gold standard. Compares the results of numerous studies on a particular question.
Term
T-test
Definition
Compares means from two groups
Term
Chi-squared test
Definition
Association between two categorical variables
Term
Correlation & regression
Definition
Linear relationship between two continuous variables.
Term
Primordial prevention
Definition
Actions at a government level to ensure underlying socioeconomic and environmental conditions limit the development of disease.
Term
Primary prevention
Definition
Targets those with specific risk factors at the population level.
Term
Secondary prevention
Definition
Early detection and treatment
Term
Tertiary
Definition
Reduce progression of disease and complications once it has occurred.
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