Term
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Definition
| continue to function even when removed from celss |
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Term
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Definition
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Term
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Definition
| transient carries of specific functional groups |
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Term
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Definition
| coenzyme or metal ion bound together with an enzyme |
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Term
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Definition
| catalytically active enzyme together with its bound coenzyme or metal ion |
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Term
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Definition
| protein part of holoenzyme |
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Term
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Definition
| where the enzyme-catalyzed rxn takes place |
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Term
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Definition
| molecule bound in the active site and acted on by the enzyme |
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Term
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Definition
| starting point of the rxn |
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Term
| Standard free-energy change |
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Definition
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Term
| biochemical standard free-energy change |
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Definition
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Term
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Definition
| top of the curve on a rxn coordinate |
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Term
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Definition
| deltaG, the difference between the ground state and transition state |
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Term
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Definition
| formation and decay of transient chemical species |
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Term
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Definition
| determined by the slowest step (the step that requires the most activation energy) |
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Term
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Definition
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Term
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Definition
| k=1.38*10e-23(T)(e^(-deltaG/RT))/6.63*10e-34 |
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Term
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Definition
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Term
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Definition
| energy derived from enzyme-substrate interaction |
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Term
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Definition
| the ability to discriminate between a substrate and a competing molecule |
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Term
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Definition
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Term
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Definition
| the release of bound water from the substrate |
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Term
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Definition
| when a substrate binds, both the substrate and enzyme undergo conformation (change in shape) |
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Term
| specific acid-base catalysis |
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Definition
| acid-base catalysis involving the two constituents of water |
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Term
| general acid-base catalysis |
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Definition
| catalysis involving the transfer of a proton to form a water molecule |
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Term
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Definition
| process of determining the rate of the rxn and how it changes in response to experimental parameters |
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Term
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Definition
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Term
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Definition
| Fastest speed a rxn can take place |
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Term
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Definition
| time at which substrates bind to most of the enzymes if not all |
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Term
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Definition
| products remain constant over time |
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Term
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Definition
| analysis of initial rxn rates |
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Term
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Definition
| formation of ES = breakdown of ES |
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Term
| michaelis-menten equation (rate equation) |
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Definition
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Term
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Definition
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Term
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Definition
| breakdown of a complex into two or more biomolecules |
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Term
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Definition
| # of substrates converted to product in a given unit of time |
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Term
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Definition
| rate constant for the conversion of E+S to E+P. |
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Term
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Definition
| inhibitor of an enzyme that doesn't affect the enzyme for future rxns once the inhibitor is no longer bound |
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Term
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Definition
| competes with the substrate for the active site of an enzyme |
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Term
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Definition
| doesn't bind to active site, and will bind to either ES or E |
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Term
| noncompetitive inhibition |
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Definition
| a random molecule effects the S from being about to bind to the active site by blocking it |
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Term
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Definition
| undergoes normal enzymatic rxn but instead of being transformed into the normal product, the E becomes very reactive and irreversibly binds to the inactivator |
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Term
| mechanism-based inactivators |
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Definition
| product formed by suicide inactivators |
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Term
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Definition
| enzymes that cleave beta-lactam antibiotics |
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Term
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Definition
| possess an RNA genome and an enzyme, reverse transcriptase, that uses its RNA to synthesize DNA in the host cell |
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Term
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Definition
| regulate catalytic activity |
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Term
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Definition
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Term
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Definition
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Term
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Definition
| rate is slowed or sped up based on the need of the product; the more product the slower the rxn |
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Term
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Definition
| catalyzes the attachment of phosphoryl groups to specific amino acids |
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Term
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Definition
| removes catalyzed phosphoryl groups |
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Term
| zymogen (proproteins/propenzymes) |
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Definition
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