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Enzymes of Metabolism
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24
Biochemistry
Undergraduate 3
04/16/2012

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Term
Hexokinase
Definition
Glucose -> Glucose-6P
Control point enzyme;
Coupled with ATP -> ADP;
acts on any hexose
Term
Phosphoglucose Isomerase (PGI)
Definition
G6P -> Fructose-6P
Acts on any hexose
Term
Phosphofructokinase (PFK-1)
Definition
F6P -> Fructose-1,6BP (FBP)
Control point enzyme;
Coupled with ATP -> ADP
Term
Aldolase
Definition
FBP -> DihydroxyacetoneP (DHAP) + Glyceraldehyde-3P (GAP)
Term
Triose P Isomerase
Definition
DihydroxyacetoneP (DHAP) -> Glyceraldehyde-3P (GAP)
Bridge to E production phase;
Occurs twice for every glucose
Term
Glyceraldehyde-3P Dehydrogenase (GAPDH)
Definition
Glyceraldehyde-3P (GAP) -> 1,3-BPG
Coupled with NAD+ -> NADH;
Creates HIGH E MOLECULE
Term
Phosphoglycerate Kinase (PGK)
Definition
1,3-BPG -> 3-P glycerate (3PG)
Coupled with ADP -> ATP;
Creates ATP!
Term
Phosphoglycerate Mutase (PGM)
Definition
3-P glycerate (3PG) -> 2-P glycerate (2PG)
Term
Enolase
Definition
2-P glycerate (2PG) -> P enolpyruvate (PEP)
Creates HIGH E MOLECULE
Term
Pyruvate Kinase (PK)
Definition
P enolpyruvate (PEP) -> Pyruvate
Control point enzyme;
Coupled with ADP -> ATP;
Creates ATP!
Term
Pyruvate Dehydrogenase
Definition
Pyruvate -> Acetyl CoA after glycolysis & before TCA
Term
Hexokinase allosteric modulators
Definition
Glucose-6P (-)
Term
Phosphofructokinase (PFK-1) allosteric modulators
Definition
ADP/AMP (+)
Fruc-1,6BP (+) Permanent
ATP (-)
Citrate (-) From TCA Cycle
Term
Pyruvate Kinase (PK) allosteric modulators
Definition
ATP (-)
Fruc-1,6BP (+)
Term
Lactate Dehydrogenase (LDH)
Definition
Pyruvate -> Lactate
Coupled with NADH -> NAD+
Term
Fructose-1-P Aldolase
Definition
Fructose-6-P -> glyceraldehyde + dihydroxyacetoneP (DHAP)
In LIVER when Fructose has been eaten :)
Term
Glycerol Kinase
Definition
Glycerol -> Glycerol-3-P
When excess of fructose has been eaten
Term
Gluctose-6-P Dehydrogenase
Definition
NADP+ -> NADPH
Control Point for PPP
Term
6-P-Gluconate Dehydrogenase
Definition
NADP+ -> NADPH
In PPP
Term
Glutathione Peroxidase
Definition
GSH -> GSSG (ox)
Free radical -> water (red)
In Glutathione Cycle
Term
Superoxide Dismutase
Definition
O2 radical from oxphos -> H2O2
Term
Glutathione Reductase
Definition
NADPH -> NADP+ (ox)
GSSG -> 2GSH (red)
In Glutathione Cycle
Term
BPG Mutase
Definition
1,3BPG from glycolysis -> 2,3BPG for high altitudes
Term
2,3BPG Phosphatase
Definition
2,3BPG -> 3-PG dumped back into glycolysis at lower altitudes
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