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Enzymes B
Enzymes B
28
Chemistry
Undergraduate 1
11/18/2008

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Term
What holds substrate at active site?
Definition
chemical bonds
physical interactions
Term
Describe lock and key model for enzymes
Definition
enzyme is rigid 3D body
Enzyme surface contains the active site
Term
Describe the induced fit model.
Definition
Actie site becomes modified to accommodate the substrate
Term
Which amino acids participate in teh active sites of more than 65% of enzymes
Definition
His/Cys/Asp/Arg/Glu
Term
What occurs at the active site?
Definition
selection of a stereoisomer
Term
What is at the active site of Trypsin?
Definition
A well for Lysine.
Term
What is the well for that is created by Chymotrypsin?
Definition
Phenylalanine, Tryptophan, and Tyrosine
Term
What factors affect teh rate of an enzyme-catalyzed reaction?
Definition
1. enzyme concentration
2. substrate concentration
3. temperature
4. pH
Term
What is activation:
Definition
any process that initiates or increases the activity of an enzyme
Term
What is inhibition:
Definition
any process that makes an active enzyme less active or inactive
Term
What is a competitive inhibitor:
Definition
any substance that binds to the active site of an enzyme thereby preventing binding of substrate
Term
What is a noncompetitive inhibitor
Definition
Any substanc hat binds to a portion of the enzyme othr than the active site and thereby inhibits the activity of the enzyme
Term
Which has more of a detrimental effect on the enzyme- competitive inhibitor or noncompetitive inhibitor
Definition
noncompetitive inhibitor
Term
What is FEEDBACK CONTROL
Definition
An enzyme regulatin process where the product of a series of enzyme-catalyzed reactions inhibits an earlier reaction in the sequence. The inhibition may be cometitive or noncompetitive
Term
Name an inactive form of an enzyme
Definition
Proenzyme-zymogen
Term
How does an inactive form of an enzyme become activated?
Definition
Part of a polypeptide chain must be removed by hydrolysis to activate the enzyme
Term
What is an example of a proteolytic enzyme
Definition
Trypsin (proteolytic enzyme) synthesized and stored as trypsinogen
Term
How does the molecule achieve its active form?
Definition
Changing the primary structure changes the tertiary structure allowing the molecule to achieve its active form
Term
What is Allosterism?
Definition
Enzyme regulation based on an event occurring at a place other than the active site but that creates a change in the active site
Term
Do Allosteric enzymes have multiple polypeptde chains?
Definition
Yes
Term
What is negative and positive modulation of an Allosteric enzyme
Definition
Negative -inhibition of an allosteric enzyme
Postivie-stimulation of an allosteric enzyme
Term
What is a regulator in regard to an Allosteric enzyme?
Definition
A substance that binds to an allosteric enzyme
Term
How does protein modification work with regard to enzyme regulation?
Definition
the process of affecting enzyme actibity by covalently modifying it....phosphorylation and dephosphorylation
Term
What is an enzyme that occurs in multiple forms, each catalyzes the same reaction?
Definition
Isoenzyme
Term
What is an example of an isoenzyme?
Definition
Lactate dehydrogenase catalyzes the oxidation of lactate to pyruvate
Term
What medical diagnosis is made by Acid phosphatase?
Definition
Prostate cancer
Term
What diagnosis is made by creatine phosphokinase ck?
Definition
heart attack
Term
What diagnosis is made by amylase?
Definition
Pancreatic disease
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