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Enterobacteriaceae
3/7/2011 gasstrointestinal disease
30
Microbiology
Undergraduate 3
04/04/2011

Additional Microbiology Flashcards

 


 

Cards

Term

enterobacteriaceae

name two kinds

Definition

salmonella spp

shigella spp

Term

salminella spp.

five major pathogens?

Definition

s. thyphimurium

s. choleraesuis

s. enteritidis

s. typhi

s. paratyphi

Term
characteristic of salmonella
Definition

gram negative

motile (flagellated) bacillus

non-lactose fermenter (on agar plate, shows up black)

Term

on an envelope of salmonella, what are major antigens?

 

Definition

LPS: >2400 O serotypes

>119 Hantigens for flagellum

Term
among five salmonella species, which patogen causes gastroenteritis aka, food poisoning?
Definition

salmonella enteritidis

invasive bacterium

Term
site of action of s. enteritidis?
Definition
intestine
Term
duration of gastrointeritidis?
Definition

2-4days

self-limiting

Term

salmonella elicit _____ of the ____ cytoskeleton of the host cell.

 

___ is observed b4 invasion by salmonella into the host cell

Definition

rearrangement

actin

 

ruffling

Term
risk group for s. enteritidis?
Definition
birds, human
Term
among the five salmonella species, which causes typhoid fever?
Definition
salmonella typhi
Term
risk group for typhoid fever?
Definition
ONLY human
Term
for typhoid fever, after dissemination from intestine via macrophages to the lymphatics, bloodstream, liver, kidneys, gall bladder, it causes
Definition
systemic bacteremia
Term
one of the serious effect of typhoid fever is
Definition

hemorrhagic ulceration

spilling gut into abdomen

Term
entery of typhi is where?
Definition
gut tpithelium then becomes systemtic
Term
virulence proteins expressed by salmonella?
Definition

pathogenicity island; virulence genes are clustered

SPI-1

Term

how do you know that SPI-1 gene is virulence factor?

 

Definition
with mutaion in SPI-1 gene, salmonella can't do its job
Term
what does SPI-1 encode for?
Definition
Type III secretion system
Term
what is Type III secretion system?
Definition

this introduces protein into the cytoplasm of the infected cell

 

Effector proteins manipulate cell function

Term
type III secretion system injhects ____ into the cell
Definition

SIP

salmonella invasion protein

 

to epithelial cells

Term
SPI-2 encodes for
Definition

SSEE

 

almonella secretion effector protein

 

in phagocytes

Term
what is a causative agent for bacillary dysentery ?
Definition
shigella spp.
Term
four species of shigella?
Definition

shigella boydii

shigella flexneri

shigella sonnei

shigella dysenteriae

Term
reservoir for shigella?
Definition

obligate human pathogen so

only human

Term
characteristic of shigella
Definition

gram negative

non-motile

not ferment lactose

Term
on hektoen enteric agar, shigella spp presents
Definition
green, raised, moist colonies
Term
envelope of a shigella spp, what are some major antigens used for serotyping?
Definition

~45 O anigen

LPS much less diverse than salmonella

NO flagellar antigen

Term
site of onset of shigella?
Definition

submucosal cells of the lining of the intestine

invades thru m cell

 

localized to the gut

Term
invasive phenotype of shigella is encoded by
Definition
a large virulence plasmid which encodes Ipa and type III secretion system
Term
thpe III secretion system in shigella function?
Definition
injects Ipa proteins into the cell
Term
how does shigella mobilize?
Definition
by rearranging actin
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