Term
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Definition
-DIRECT: GH binds directly to receptor on target cell
-INDIRECT: GH promotes release of IGF-1 from liver and other tissues which goes on to initiate responses |
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Term
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Definition
-you get fatter and bone density decreases
-frailty, muscle atrophy, obesity, crappy sleep |
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Term
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Definition
| -GH deficiency during childhood causing retarded sk. growth, poorly dev muscles and excess sub Q fat (due to decreased lipolysis) |
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Term
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Definition
-GH insensitivity/resistance
-very rare (250 cases worldwide)
-mutation in GH receptor (dwarfism sxs) |
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Term
| Thyroid Hormone Synthesis Steps |
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Definition
-uptake and concentration of I within the gland
-ox and incorporation of I into Tyr
-coupling of 2 iodinated Tyr |
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Term
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Definition
-Autoimmune destruction of Thyroid
-LOW Thyroid hormone/HIGH TSH |
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Term
| Hypothyroidism due to AP/hypothalmic failure |
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Definition
| LOW Thyroid hormone and LOW TSH |
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Term
| Iodide deficiency will cause |
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Definition
| LOW thyroid hormone (GOITTER) and very high TSH |
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Term
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Definition
autoimmune dz causing hyperthyroidism due to activating the TSH receptor and increasing T hormone synth and secretion.
-will see high T hormone level and LOW TSH |
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Term
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Definition
-Excess TSH will cause excess T hormone
-also, a hypersecreting thyroid tumor (HIGH t hormone and low TSH) |
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Term
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Definition
-cortisol
-aldosterone
-androgens
(steroid hormones) |
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Term
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Definition
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Term
| 3 things to know about Cortisol secretion |
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Definition
| -it's pulsatile, diurnal and stim by stress |
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