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Endocrinology
Lecture 4 Part 1
126
Pathology
Graduate
06/23/2014

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Term
Endocrine Functions: 1
Definition
Differentiation of the reproductive system and CNS in the developing fetus
Term
Endocrine Functions: 2
Definition
Stimulation of growth and development during childhood and adolescence
Term
Endocrine Functions: 3
Definition
Coordination of the male and female reproductive systems
Term
Endocrine Functions: 4
Definition
Maintenance of the optimal internal environment
Term
Endocrine Functions: 5
Definition
Initiation of corrective and adaptive resposnes when emergency situations arise
Term
Neural pathways connect the _______ gland to the ______ gland
Definition
hypothalmus, pituitary
Term
Disorders of the hypothalmus pituitary gland connectoin may cause
Definition
excess/deficient hormone levels
Term
tropic hormones are also known as
Definition
stimulating
Term
effect hormones are also known as what
Definition
inhibiting
Term
The posterior pituitary gland secretes what?
Definition
oxytocin, antidiuretic hormone
Term
What does oxytocin do?
Definition
stimulates uterine contraction and milk letdown reflex in lactating women
Term
What does ADH do?
Definition
changes the permeability in the renal system controlling concentration of bodily fluids
Term
ADH
Definition
Antidiuretic Hormone
Term
What does the anterior pituitary gland secrete?
Definition
prolactin
Term
What does prolactin stimulate?
Definition
milk production, human grown hormone
Term
What does HGH do?
Definition
increases protein synthesis by decreasing carb utilization
Term
Hyposecretion of HGH results in
Definition
dwarfism
Term
Hypersecretion of HGH results in
Definition
giantism, acromegaly
Term
The thyroid gland secretes what?
Definition
T3, T4
Term
T3
Definition
triiodothyronin
Term
T4
Definition
thyroxine
Term
The thyroid is responsible for what?
Definition
normal growth and development, maintenance of basal metabolism
Term
Hypothyroidism leads to
Definition
decreased metabolism
Term
Hyperthyroidism
Definition
increases metabolism
Term
The parathyroid gland secretes what?
Definition
parathyroid hormone
Term
Which hormone is essential for metabolism of calcium and phosphorus?
Definition
PTH
Term
Which hormone is essential for calcification of bone?
Definition
PTH
Term
What cells does the pancreas have?
Definition
alpha and beta
Term
The alpha cells secrete what?
Definition
glucagon
Term
The beta cells secrete what?
Definition
insulin
Term
A fasting state releases what hormone?
Definition
glucagon
Term
Which hormone releases stored glucose and raises the blood glucose level?
Definition
glucagon
Term
Which hormone is associated with a nourished state?
Definition
insulin
Term
Insulin's Role: 1
Definition
Facilitates glucose transport
Term
Insulin's Role: 2
Definition
promotes glucose storage
Term
Insulin's Role: 3
Definition
stimulates protein synthesis
Term
Insulin's Role: 4
Definition
increases free faty acid uptake and storage
Term
An insulin deficiency leads to...
Definition
diabetes
Term
An insulin excess leads to..
Definition
hyperglycemia
Term
THe adrenal medulla produces and releases...
Definition
epinephrine and norepinephrine
Term
Epinephrine and norepinephrine are responsbile for what?
Definition
flight or flight
Term
The underlying cause for dysfunction within the endocrine system may be a result of
Definition
inflammation, tumor
Term
If inflammation is chronic, it may lead to glandular ______
Definition
hypofunction
Term
This may leads to serious health concerns and the need for lifelong hormone replacement therapy
Definition
hypofunction
Term
An example of a tumor causing glandular dysfunction is...
Definition
goiter
Term
This may lead to hormone production of a hormone-like substance from an abnormal source
Definition
tumor
Term
production of a hormone or a hormone-like substance from an abnormal source
Definition
ectopic hormone production
Term
Ectopic hormone production may affect
Definition
musculoskeletal system
Term
Glandular _______ is common with tumors
Definition
hyperfunction
Term
Specific Glandular Changes: Pituitary Gland
Definition
loses ~75% of its mass, blood supply is reduced, higher rate of adenomas and cysts present
Term
Specific Glandular Changes: Thyroid gland
Definition
loses mass, becomes fibrotic, position changes, blood supply reduced, secretions diminished
Term
Where does the thyroid gland move to?
Definition
retrosternally
Term
Specific Glandular Changes: Parathyroid gland
Definition
loses mass, reduced blood supply, no significant alteration in secretion
Term
Specific Glandular Changes: Adrenal Glands
Definition
become more fibrotic but there is no significant decrease in cortisol production
Term
Specific Glandular Changes: Reproductive Glands: Ovarian
Definition
age-related changes have direct effects on the cardiovascular system and skeletal system
Term
Specific Glandular Changes: Reproductive Glands: Testicular
Definition
muscle mass, libido
Term
What leads to changes in teh female's reproductive systems, genitourinary tract, lipid composition, accelerates demineralization of bone
Definition
Term
What have shown to help preserve bone and muscle mass but may lead to increased incidence of certain diseases
Definition
male hormones
Term
Signs of endocrinopathy and hyposecretion of hormones: 1
Definition
Loss of body hair
Term
Signs of endocrinopathy and hyposecretion of hormones: 2
Definition
changes in the skin's collagen content
Term
Signs of endocrinopathy and hyposecretion of hormones: 3
Definition
increase in body fat percentage
Term
Signs of endocrinopathy and hyposecretion of hormones: 4
Definition
decrease in bone mass
Term
Signs of endocrinopathy and hyposecretion of hormones: 5
Definition
disrupted sleep
Term
Signs of endocrinopathy and hyposecretion of hormones: 6
Definition
increase in protein synthesis
Term
Potential ptnt impairments
Definition
fatigue, muscle weakness, muscle/bone pain
Term
RA, adhesive capsulitis, CTS may not be diagnosed with an _______ disorder
Definition
endocrine
Term
role of the PT and ednocrine disorders
Definition
be aware of systemic signs and symptoms
Term
Insulin dependent diabietes mellitus, juvenile onset
Definition
Type 1
Term
Type 1 is caused by
Definition
underproduction of insulin and secretion
Term
Do type 1 diabetics require exogenous insulin?
Definition
yes
Term
non-insulin dependent diabetes mellitus, adult onset diabetes
Definition
Type 2
Term
Caused by both a cellular resistance to insulin action and an inadequate insulin secretory response
Definition
type 2
Term
Type 1 Diabetes destroys what cells of the pancreas?
Definition
beta
Term
Type 2 diabetes involves what
Definition
ineffective insulin action at the cellular level
Term
Autoimmune destruction of beta cells occurs in which type of diabetes?
Definition
type 1
Term
Insulin is secreted by what
Definition
islets of langerhans
Term
What is insulin's function?
Definition
transport glucose into the cell for energy, stimulates protein synthesis and storage of fat
Term
Beta cells increase the secretion of insulin after a meel in order to
Definition
transport and dispose of the glucose into the peripheral tissues, decrease the blood glucose levels
Term
WHere else is glucose deposited for storage?
Definition
liver
Term
Insulin Deficiency: Problem 1
Definition
decreased utilization of glucose
Term
Insulin Deficiency: Problem 2
Definition
increased fat metabolism
Term
Insulin Deficiency: Problem 3
Definition
impaired protein utilization
Term
Type 1 Diabetes: Digestion: Step 1
Definition
Stomach changes food into glucose
Term
Type 1 Diabetes: Digestion: Step 2
Definition
Glucose enters teh bloodstream
Term
Type 1 Diabetes: Digestion: Step 3
Definition
Pancreas makes little to no insulin
Term
Type 1 Diabetes: Digestion: Step 4
Definition
Little or no insulin enters the bloodstream
Term
Type 1 Diabetes: Digestion: Step 5
Definition
Glucose builds up in the bloodstream
Term
Type 2 Diabetes: Digestion: Step 1
Definition
Stomach changes food into glucose
Term
Type 2 Diabetes: Digestion: Step 2
Definition
Glucose enters teh bloodstream
Term
Type 2 Diabetes: Digestion: Step 3
Definition
Pancreas makes insulin
Term
Type 2 Diabetes: Digestion: Step 4
Definition
Insulin enters the bloodstream
Term
Type 2 Diabetes: Digestion: Step 5
Definition
Glucose can't get into teh cells of the body. Glucose builds up in the blood vessels
Term
Chronic hyperglycemia may result in
Definition
blood vessel damage
Term
Blood vessel damage as a result of hyperglycemia is common where?
Definition
coronary, cerebral, peripheral
Term
Common organ failures due to ischemia as a result of hyperglycemia
Definition
kidneys, retinas
Term
Clinical Picture: DM1: 1
Definition
polyuria
Term
Clinical Picture: DM1: 2
Definition
polydipsia
Term
Clinical Picture: DM1: 3
Definition
weight loss despite polyphagia
Term
Clinical Picture: DM1: 4
Definition
blurred vision
Term
polyuria
Definition
increased urinary frequency
Term
polydipsia
Definition
thirst
Term
polyphagia
Definition
increased appetite
Term
Clinical Picture: DM1: Early onset of ______ is also common due to hyperglycemia and increased fat metabolism
Definition
atherosclerosis
Term
Clinical Picture: DM2: 1
Definition
blurred vision
Term
Clinical Picture: DM2: 2
Definition
neuropathic complications
Term
Clinical Picture: DM2: 3
Definition
infection
Term
Clinical Picture: DM2: 4
Definition
blood lipid abnormalities
Term
Clinical Picture: DM2: Long-term complications: 1
Definition
neuropathy
Term
Clinical Picture: DM2: Long-term complications: 2
Definition
retinopathy
Term
Clinical Picture: DM2: Long-term complications: 3
Definition
nephropathy
Term
Clinical Picture: DM2: Long-term complications: 3
Definition
increased risk of cornoary artery disease, stroke, peripheral vascular disease
Term
Diabetic patient should always do what pre and post exercise?
Definition
assess blood-glucose level
Term
Diabetes and Exercise: Benefits: 1
Definition
improved CV function
Term
Diabetes and Exercise: Benefits: 2
Definition
improved max O2 uptake
Term
Diabetes and Exercise: Benefits: 3
Definition
improved insulin binding and sensitivity
Term
Diabetes and Exercise: Benefits: 4
Definition
lowered insulin requirements
Term
Diabetes and Exercise: Benefits: 5
Definition
incresaed carbohydrate metabolism
Term
Diabetes and Exercise: Benefits: 6
Definition
reduced hypertension
Term
Diabetes and Exercise: Benefits: 7
Definition
weight loss and stress reduction
Term
Diabetes and Exercise: Risks: 1
Definition
hypoglycemia
Term
Diabetes and Exercise: Risks: 2
Definition
worsening of hyperglycemia
Term
Diabetes and Exercise: Risks: 3
Definition
certain CV disorders
Term
Diabetes and Exercise: Risks: 4
Definition
microvascular disease (i.e retinal hemorrhage)
Term
Diabetes and Exercise: Risks: 5
Definition
degenerative joint disease
Term
Diabetes and Exercise: Risks: 6
Definition
orthopedic injury related to peripheral neuropathy
Term
Leading cause of hospital admission in diabetics
Definition
foot problems leading to amputation
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