Term
| should you discountinue if you see distensitazation ? |
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Definition
| NO. Becaucse receptors may be supersensitize. |
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Term
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Definition
1-due to change in the location that makes the hormone
2- change in receptor structure |
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Term
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Definition
| oppose the effect of desensitization |
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Term
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Definition
| lack of hormone or presense of inhobitor |
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Term
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Definition
| E max dec. no change in EC 50 |
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Term
| response to reseptor is a known function :T or False |
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Definition
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Term
| psartial agonist no sprae receptors |
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Definition
| you dont spare receptors: you wont get the max effect |
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Term
| agonist with spare receptors |
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Definition
| you get increase response |
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Term
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Definition
| you get flat line bottim of the curve. no response ......... Dead :X |
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Term
| Do not mix affinity with efficacy |
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Definition
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Term
| Higher affinity means higher efficacy : true or False>? |
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Definition
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Term
| From the substance receptor complex that shows the affinity of the receptor you cant tell if the substance is agonist, antagonist, partial agonist !!! |
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Definition
| Affinity and Efficacy are indep. parameters |
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Term
| from the decrease in the EC50 alone (same E max) you can't tell if the substance is competative inhibitor or non competative inhibitor. GOT ITTTTT |
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Definition
| yes TRUE .....look at the graph |
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Term
| both competative and non competative inhibitor will inhibit (decrease response) an endogenous hormon : T F? |
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Definition
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Term
| inverse agonist = negative efficacy |
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Definition
| mutation , virus, binds to receptor turn it off, negative efficacy. |
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Term
| which plot do you use to interpret cooperativity? |
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Definition
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Term
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Definition
| slope of hill plot is more steep =greater than 1.... you need less of the hormone for the unoccupied receptor. |
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Term
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Definition
| slope of hill plot is negative. you need more hormone for the unoccupied receptor to cause the same effect. |
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Term
| positve coperativity for a receptor of a drug ....you need more drug or less drug to get to a desired response? |
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Definition
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Term
| if the hormone binds to heterogenous receptor the plot looks like? |
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Definition
| the plot of binding will look like negative cooperativity. |
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Term
| what if you cant distinguish between negative coop and heretrogenity???? |
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Definition
| Apparent negative cooperativity. |
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Term
| repeated or continuous exposure of a cell to hormon dimonishes the response to subsequence dose |
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Definition
| desensitization, refractoriness, tachyphalaxis |
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Term
| Homologous desensitization |
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Definition
| it is specific to one hormone |
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Term
| Heterologous desensitization |
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Definition
| desensitization towards multiple hormones... act on diff receptors but have same effect |
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