Term
| What is the most common cause of Hypothyroid in patients with adequate Iodine intake |
|
Definition
|
|
Term
| What are some common Antigens attacked in Hashimoto's? |
|
Definition
Thyroid Peroxidase
TSH Receptor
Thyroglobulin |
|
|
Term
| What is the typical histology of hashimoto's thyroiditis? |
|
Definition
Lymphocytic Infiltrate with Lymph Nodules
Atrophic Follicles with Hurthle Cell-Oncocytic cells(form of Metaplasia)(Eosinophillic)
Fibrosis increases with time
|
|
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Term
| What is a comorbid risk of any Autoimmune disease |
|
Definition
| Having another Autoimmune Disorder |
|
|
Term
| How is hashimoto's thyroiditis diagnosed |
|
Definition
| Ab detection in the blood |
|
|
Term
| How would the fibrosing variant of hashimoto's appear |
|
Definition
| Dense collagen deposition similar to keloid histology |
|
|
Term
| How can Hashimotos present clinically |
|
Definition
A)Slow Hypothyroid
B)Rapid Thyrotoxicosis (Transient Hashitoxicosis)-> Slow Hypothyroid |
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|
Term
| What is the histology of Subacute Granulomatous Thyroiditis? |
|
Definition
PMN Microabcesses
Multinucleated Giant Cells
Epitheliod Histiocytes |
|
|
Term
| What is the presumed etiology, presentation and prognosis of De Quervain's Thyroiditis |
|
Definition
Et:Viral
Pres: Neck Pain w/ Flu like Symptoms, 2-6 wks Hyperthyroid->2-6 wks Hypothyroid
Prog: Complete Recovery |
|
|
Term
| What is the clinical triad of Graves Disease |
|
Definition
Hyperfunctioning Goiter
Infiltrative Opthalmopathy
Infiltrative Dermopathy |
|
|
Term
| What are the common antigens of Graves Disease |
|
Definition
TSH Receptor: Thyroid stimulating immunoglobulin, Thyrotropin binding inhibitor immunoglobulin
|
|
|
Term
| Treatment of Graves Disease |
|
Definition
| Surgery and Radioactive Iodine |
|
|
Term
| What are the common causes of Multinodular Nontoxic Goiter |
|
Definition
Iodine Deficiency
Goiterogenics
Hereditary defects |
|
|
Term
| What is the histology of Multinodular Nontoxic Goiter |
|
Definition
| Areas of distended follicles and other cellular colloid-poor areas |
|
|
Term
| When is a thyroid nodule more likely to be a malignant lesion |
|
Definition
Young Patient
Male
Solitary
Non-functional |
|
|
Term
| What is the structure of a folicular tumor of the thyroid and how do you differentiate a carcinoma from an adenoma |
|
Definition
Completely encapsulated lesion with more cellular stroma
Carcinoma will have capsule busting or vessel spread |
|
|
Term
| What is the histology of an papillary carcinoma of the thyroid |
|
Definition
Papillary projections
Orphan Annie Cell's(Clear Chromatin)
Psammoma Bodies |
|
|
Term
| What is the difference in metastasis of papillary verses follicular carcinoma of the thyroid |
|
Definition
Papillary spreads via lymph
Follicular spreads via blood |
|
|
Term
| How does the prognosis differ between the types of thryroid carcinomas |
|
Definition
Papillary Best
Anaplastic Worst
|
|
|
Term
| What is the histology of medullary carcinoma of the thyroid |
|
Definition
Nests of Polygonal/spindle cells
Amyloid
Calcitonin Immunostain |
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