Term
| What is the physiology of statural bone growth |
|
Definition
A)Growth plate with resting, proliferative and hypertrophic zones
B)Hypetrophic zones deposit cartilage matrix C)C)Neovascularization brings osteoblast and osteoclasts to resorb cartilage and deposit bone
D)Rate of growth regulated by nutient supply and hormone induction |
|
|
Term
| What is the definition of short stature and what are the two categories |
|
Definition
Height below 3rd Percentile
Types: Variants of Normal, Pathological Short Stature |
|
|
Term
| What are some reasons why a child would have short stature and be variant of normal growth |
|
Definition
Short Family
Delay of Growth
Sometimes Both |
|
|
Term
| How would you estimate the projected height of a child based on the height of the child's parents |
|
Definition
Male:(Dad's Height+Mom's Height+13cm)+/-2
2
Female(Dad's-13cm+Mom's)+/-2cm
2 |
|
|
Term
| How fast do children grow during ages 3-12 |
|
Definition
|
|
Term
| When should children be measured in the supine position versus the standing position |
|
Definition
Supine: birth to 36 months
Standing: 24 months to 18 yrs |
|
|
Term
| What are the most common causes of pathological short stature |
|
Definition
Prenatal: IUGR, Bone Dysplasia, Chromosome Abnormalities
Postnatal: Malnutrition, Chronic Disease, Endocrine, Drugs(Stimulants,Glucocorticoids), Psychosocial
|
|
|
Term
| What are some signs of GH deficiency |
|
Definition
| Normal growth for first 6 months followed by decline and hypoglycemia |
|
|
Term
| Describe the growth pattern with Precocious puberty |
|
Definition
| Early Rapid growth followed by eventual short stature |
|
|
Term
| What patients should be worked up for short stature |
|
Definition
Height below 3rd percentile
Significantly below target height
Moving downward crossing Percentiles after 18 months |
|
|
Term
| What are the diagnostic tests typically used in assessing short stature |
|
Definition
CBC, SMA7, Renal,ESR
TSH, T4
IGF-1
Bone Age(x-ray) |
|
|
Term
| What are some endocrine disorders that can produce short stature |
|
Definition
Hypothyroid
GH Deficiency/Insensitivity
Diabetes Mellitis
Cushing's
Precocious Puberty |
|
|
Term
| What should you always consider as a cause for poor growth in a girl |
|
Definition
|
|
