Term
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Definition
| a ton of stuff... you probably got it right. just remember it is short acting |
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Term
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Definition
ultra-short acting insulin analogue.
given subQ with Zn. forms hexamer(insoluble) must form monomer.
the B chain is modified to decrease stability of hexamer |
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Term
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Definition
Intermediate insulin analogue
NPH:
premixable. stabalized by protamine (slow off time)
Lente:
not premixable. high Zn content increases stability. |
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Term
Glargine
Detemir
Ultralente |
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Definition
Long acting insulin analogue
Ultralente: higher Zn content
Glargine/Detemir: increased B chain stability |
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Term
tolbutamide
chlorpropamide
tolazamide
acetohexamide |
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Definition
1st gen. sulfonylurea
Closes ATP sensitive K channels -> increase insulin exocytosis
long half life. |
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Term
glyburide
glizipide
gliclazide
glipiride |
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Definition
2nd gen sulfonylurea
close ATP sens K channels -> increase insulin exocytosis
100X potency and shorter half life than 1st gen. |
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Term
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Definition
meglitinides
similar to sulfonylureas except no sulufur. Not direct |
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Term
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Definition
metformin
increases insulins actions.
C/I: renal, hepatic, lactic acidosis |
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Term
pioglitizone
rosiglitazone
troglitazone |
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Definition
Thiazolidinediones
increase insulin action by increasing GLUTs via binding to PPARg NR
watch out for liver and fluid retent. |
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Term
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Definition
glucosidase inhibitor:
decrease glucose uptake in gut.
makes you fart. |
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Term
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Definition
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Term
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Definition
| inhibits dipeptidyl peptidase-4 (which degrades GLP-1) |
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Term
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Definition
amylin analogue
slows gastric emptying and promotes satiety. |
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Term
| What do ethanol, salicylates, and b-blockers have in common? |
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Definition
| they are all hypoglycemic... get it? |
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Term
epinephrine
b2-agonist
glucocorticoids
diazoxide
diuretics
Ca channel blocker
clondine
phenytoin |
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Definition
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Term
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Definition
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Term
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Definition
| enhance residual ADH FX in kidney |
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Term
thiazides
indomethacin
Amiloride |
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Definition
nephrogenic DI Rx
indo inhibits PG's
Amiloride is for Li(which inhibits V2) induced DI |
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Term
Demeclocycline
Li
Conivaptan |
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Definition
SIADH Rx
Demeclocycline: inhibit ADH signaling
Li inhibits V2
Conivaptan: ADH R blocker |
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Term
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Definition
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Term
misoprostil
Ergonovine
methylergonovine |
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Definition
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Term
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Definition
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Term
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Definition
| tocolytic: Ca channel blocker |
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Term
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Definition
Tocolytic: inhibits PG's
don't close that DA |
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Term
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Definition
| tocolytic: oxytosin R blocker |
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Term
Somatropin
somatrem
mecasermin |
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Definition
GH deficiency Rx:
soma... : analogues
Mecasermin: IGF-1 analogue w/ BP (use for GH resistance) |
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Term
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Definition
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Term
monotropin
urofollitropin
Follitropin |
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Definition
Fertility Drugs:
M: LH and FSH
U: mainly FSH
F: recombinant FSH |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
gonadarelin
leuprolide
histrelin
deslorelin
nafarelin
buserelin
goserelin
triptorelin
ganirelix
cetrorelix
abarelix |
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Definition
GnRH analogue
gonadorelin is short acting and used pusitile |
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Term
Bromocriptin
cabergolin
pergolide
quinagolide |
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Definition
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Term
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Definition
| somatostatin analogue w/ longer half life |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| What do glucocorticoid, androgen, salicylates have in common? |
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Definition
| They all decrease binding of T3 to TBG |
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Term
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Definition
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Term
| What do propranolo, dexamethasone, PTU, Amiodorone, and Radiology contrast dies have in common? |
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Definition
| they inhibit type 1 5'-deiodinase |
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Term
|
Definition
thioureylenes:
inhibit thyroid peroxidase
PTU has shorter half life and inhibits peripheral T4-> T4 |
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Term
thiocyanate
perchlorate
fluroborate |
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Definition
compete with I
fatal aplastic anemia |
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Term
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Definition
| mineralocorticoid replacement |
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Term
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Definition
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Term
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Definition
GR blocker
chemical abortion |
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Term
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Definition
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Term
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Definition
| inhibit SCC, 11B-OH, aromatase |
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Term
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Definition
| 17,20- lyase and at HD SCC inhibitor |
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Term
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Definition
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Term
| why don't we use straight up estradiol (oral)? |
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Definition
| B/c we ain't hard like that... or b/c it has a really high first pass |
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Term
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Definition
| low first pass, oral, potent, |
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Term
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Definition
conjugated estrogen:
less potent, EstrogenRT, |
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Term
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Definition
SERM:
estrogen R blocker in pituitary. |
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Term
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Definition
Breast cancer Rx: post tamoxifen
full estrogen R blocker |
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Term
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Definition
SERM:
Anti-estrogen in Breast cancer
estrogenic in endometrium and bone |
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Term
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Definition
SERM: Awesome
estrogenic in bone
anti-estrogenic in breasts in endometrium |
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Term
hydroxyprogestrone caproate
" acetate |
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Definition
caproate is parenteral
acetate - oral ERT |
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Term
norethindrone
norgetrel
norgestimate
desogestrel
drospirenone |
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Definition
progestrone analogues
oral |
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Term
ANAstrozole
letrozole
aminoglutethimide |
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Definition
non-steroidal aromatase inhibitor:
reversible |
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Term
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Definition
steroidal Aromatase inhibitor:
irreversible |
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Term
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Definition
| MAB against HER2/erB-2/NEU (RTK) |
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Term
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Definition
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Term
testonsterone proprionate
cypionate
enanthate |
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Definition
test esters:
proprionate is short acting
low 1st pass |
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Term
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Definition
| GnRH analogue - decrease LH/FSH... eventually |
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Term
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Definition
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Term
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Definition
| 17,20-lyase and SCC inhibitor |
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Term
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Definition
17B-OH inhibitor
and andro R inhibitor |
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Term
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Definition
type 2 5a-reductase inhibitor
dutasteride does type 1 and 2 |
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Term
flutamide
bicalutamide
nilutamide
cyproterone |
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Definition
Andro R blocker:
bicalutamide less toxic
cyproterone also progesterone R agonist |
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Term
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Definition
sex enhancer:
fluidize RBC's ->improve blood flow |
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Term
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Definition
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Term
sildenafil
tadalafil
vardenafil |
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Definition
Sex enhancer:
inhibit cGMP phosphodiesterase |
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Term
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Definition
sex enhancer:
A1/2 blocker |
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Term
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Definition
sex enhancer:
A1/2 blocker |
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Term
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Definition
sex enhancer:
dopa agonist |
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Term
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Definition
Sex enhancer:
PGE1, inject into penis |
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Term
metronidazole
quinolones
penicillin
ceftriaxone |
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Definition
M: T. vaginalis
Q: chlamydia, gonorrhea (no prego's)
P: syphillis
C: gonorrhea |
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Term
doxycyclin
azithromycin
acyclovir, valacyclovir, famciclovir
foscarnet, ganiclovir |
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Definition
D: Chlamydia (GI elim)
A: chlamydia
cyclovir: HSV-2
F/G: CMV |
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Term
ergocalciferol
cholecalciferol |
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Definition
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Term
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Definition
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Term
calcitriol
paricalcitriol
22-oxacalcitriol
calcipotriol |
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Definition
active
P: reduces PTH
22: reduces PTH gene, low gut and bone
calcipotriol: psoriasis Rx |
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Term
DiHydroTachysterol
doxercalciferol |
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Definition
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Term
etidronate
pamidronate
alendronate
risedronate
riludronate
zoledronate
ibandronate |
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Definition
bisphosphate:
retard bone form and dissolution |
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Term
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Definition
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Term
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Definition
| antibiotic that also decreases plasma Ca via inhibition of bone resorption. |
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Term
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Definition
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Definition
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Definition
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Definition
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