Term
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Definition
| Short Acting Insulin; tx for type 1 and 2 DM, life threatening hyperkalemia and stress-induced hyperglycemia |
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Term
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Definition
| Short acting insulin; tx for type 1 and 2 DM, life threatening hyperkalemia and stress-induced hyperglycemia |
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Term
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Definition
| short acting; tx for type 1 and 2 DM, life threatening hyperkalemia and stress-induced hyperglycemia |
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Term
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Definition
| Intermediate insulin; tx for type 1 and 2 DM, life threatening hyperkalemia and stress-induced hyperglycemia |
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Term
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Definition
| Long acting insulin; tx for type 1 and 2 DM, life threatening hyperkalemia and stress-induced hyperglycemia |
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Term
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Definition
| Long acting insulin; tx for type 1 and 2 DM, life threatening hyperkalemia and stress-induced hyperglycemia |
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Term
| Tolbutamide/Chlorporpamide |
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Definition
First generation sulfonylureas
Use: Type II diabetes
Mech: Close K+ channel in B cell -- depolarizes -- cell releases insulin
Tox: disulfiram like effects |
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Term
| Glyburide/Glimepiride/Glipizide |
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Definition
Second generation sulfonylureas
Use: Type II diabetes
Mech: Close K+ channel on B cells and depolarizes, releasing insulin
Tox: hypoglycemia |
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Term
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Definition
Use: Oral hypoglycemic
Mech: insulin sensitizer
Tox: lactic acidosis |
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Term
| Pioglitazone/Rosiglitazone |
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Definition
Use: diabetes
Mech: inc target cell response to insulin
Tox: weight gain, edema, hepatoxicity, CV tox |
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Term
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Definition
Alpha-glucosidase inhibitors
Use: Diabetes
Mech: Inhibit intestinal brush border alpha-glucosidases -- delayed sugar hydrolysis and glucose absorption
Tox: GI disturbances |
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Term
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Definition
Mimetic
Use: Type II DM
Mech: decrease glucagon
Tox: hypoglycemia, nausea, diarrhea |
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Term
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Definition
GLP-1 Mimetics
Use: Type II DM
Mech: increase insulin and decrease glucogon release
Tox: Nausea, vomiting, pancreatitis |
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Term
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Definition
Use: Long term obesity management
Mech: Alters fat metabolism by inhibiting pancreatic lipase. (Orlistat gets rid of fat)
Tox: Steatorrhea, GI discomfort, reduced absorption of fat soluble vitamins, headache |
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Term
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Definition
Use:Short term and long term obesity management
Mech: Sympathomimetic serotonin and NE reuptake inhibitor
Tox: Hypertension and tachycardia |
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Term
| Propylthiouracil, methimazole |
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Definition
Use: Hyperthyroidism
Mech: Inhibit organification and coupling of thyroid hormone synthesis. Propylthiouracil decreases peripheral conversion.
Tox: Skin rash, agranulocytosis, aplastic anemia |
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Term
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Definition
| Use: GH deficiency, Turner's syndrome |
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Term
| Somatostatin (octerotide) |
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Definition
Use: acromegaly, carcinoid, gastrinoma, glucagonoma
Mech: Inhibits the release of GH, TSH, and many digestive hormones |
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Term
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Definition
| Use: stimulates labor, uterine contractions, milk let-down, controls uterine hemorrhage |
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Term
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Definition
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Term
| Levothyroxine/Triiodothyroxine |
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Definition
Use: Hypothyroidisn, myxedema
Mech: Thyroxine replacement
Tox: techycardia, heat intolerance, tremors, arrhythmias |
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Term
Glucocorticoids
(hydroxortisone, prednisone, triamcinolone, dexamethasone, beclomethasone) |
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Definition
Use: Addison's disease, inflammation, immune supression, asthma
Mech: decrease the production of leukotrienes and prostaglandins by inhibiting phosphlipase A2 and expression of COX-2
Tox: Iatrogenic Cushing's syndrome |
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Term
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Definition
Use: SIADH
Mech: ADH antagonist
Tox: Photosensitivity, abnormalities of bone and teeth, nephrogenic DI |
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