Term
| What are the POMC products involved with the melanocortinin system? |
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Definition
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Term
| What are the melanocortinin receptors involved with the melanocortinin system? |
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Definition
MC*R
Where * = 1 through 5 |
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Term
| What are the melanocortinin antagonists involved with the melanocortinin system? |
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Definition
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Term
| What are the proteins that modulate melanocortinin activity? |
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Definition
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Term
What effects does a-MSH have on the following:
Brain
skin |
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Definition
brain - inhibits food intake
Skin - acts on melanocytes |
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Term
| A mutation during processing of a-MSH in the brain will cause what? |
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Definition
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Term
| A mutation during processing of a-MSH in the skin will cause what? |
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Definition
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Term
| A mutation of MCR will cause what? |
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Definition
| sexual dysfunction/malfunction |
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Term
| A mutation in MCR4 will cause what? |
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Definition
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Term
| How does a-MSH increase the brown/black pigment in skin? |
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Definition
1. a-MSH binds to MCR1 receptors in mmb
2. Signal pathways activated (cAMP, G-protein receptors etc)
3. MITF synthesized
4. Tyr & DCI are synthesized (influence pigment) |
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Term
| Why are mice with the Agouti gene yellow? |
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Definition
| Agouti interferes (blocks) MCR1 receptors so a-MSH can't bind |
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Term
| Why do yellow mice overeat? |
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Definition
| Agouti gene also blocks MCR4 in the brain, causing overeating |
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Term
| A dominant mutation in MC1R is associated with what? |
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Definition
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Term
| A recessive mutation in MC1R is associated with what? |
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Definition
| red hair (if the person has 2 copies of the gene) |
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Term
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Definition
a melanocortinin agent which can stimulate the CNS without affecting the vascular system
used to treat erectile dysfunction without artifically increasing blood pressure |
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Term
| PT141 is an analog to what? |
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Definition
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