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Endo week 2- chemo
Pharm
31
Medical
Graduate
11/26/2018

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Cards

Term
At what cell count are most tumors clinically detectable?
Definition
1 billion
Term
What weight is considered the lethal tumor burden?
Definition
1kg
Term
In what type of cancer is surgery often used to control metastatic disease?
Definition
Ovarian
Term
What is the most common type of cancer emergency requiring surgical treatment?
Definition
Spinal cord compression
Term
What is the genetic mutation disorder that may cause some patients to elect for colectomy?
Definition
Lynch syndrome
Term
When is neo/adjuvant chemo used in relation to sugery?
Definition
Neo: before to "shrink" tumor
Adjuvant: after to eradicate remaining cancer
Term
Which type of chemo agents have a plateau killing effect, meaning a dose beyond which the increase will not result in further cell death: cell cycle specific or nonspecific?
Definition
Specific
Term
How is the plateau killing effect of cell cycle specific agents overcome?
Definition
Continuous infusion or daily boluses over several days --> maximizes exposure to cells in that phase of the cycle
Term
What are some of the long-term effects associated w/ cell cycle nonspecific chemo?
Definition
Fertility, secondary cancers
Term
What types of cancers usually involve rescue therapy?
Definition
Leukemia and lymphoma
Term
What is febrile neutropenia?
Definition
Oncologic emergency
Fever of 100.4 for more than 1hr OR single temp of 101.4 PLUS ANC (absolute neutrophil count) <500 or <1,000 and expected to fall
Term
In which phase of the cell cycle do antimetabolites exert their effect?
Definition
S phase (DNA replication)
Term
In which phase of the cell cycle do taxanes exert their effect?
Definition
M phase (arrest microtubule movement)
Term
Is chemo-induced peripheral neuropathy more sensory or motor?
Definition
Sensory
Term
From what fungus are the anthracyclines (antitumor abx) derived?
Definition
Streptomyces percetus
Term
What NT is most involved in acute chemo-induced N/V?
Definition
Serotonin
Term
What meds target the vomiting center in the medulla to prevent CINV?
Definition
Dopamine antagonists; histamine antagonists; cannabinoids
Term
What med targets the higher cortical centers of the brain contribution to CINV (fear, anticipation, etc.)?
Definition
Benzos
Term
What substances are most associated with delayed CINV?
Definition
Substance P and NK1
Term
How do we prevent CINV with high-risk agents?
Definition
NK-1 antagonists + 5HT antagonists + steroid (dexamethasone)
Term
In what types of cancer are cytokine therapies used?
Definition
Renal cell carcinoma, melanoma
Term
For what type of cancer is the BCG vaccine used?
Definition
Bladder cancer
Term
In what type of cancer is Sipuleucel-T therapy used?
Definition
Prostate
Term
What region of the monoclonal antibody mediates its affinity for a particular antigen?
Definition
Variable region
Term
What region of the monoclonal antibody mediates its ability to recruit other immune cells and molecules?
Definition
Fc region
Term
MOA of bevacizumab?
Definition
VEGF inhibitor --> inhibits angiogenesis
Term
What disease state is rituximab targeted against?
Definition
B cell lymphoma
Term
In what type of cancer do we use Ado-Trastuzumab Emtansine?
Definition
Breast
Term
Which Mabs are most likely to cause hypersensitivity rxn?
Definition
Murine (mouse) derived: Tositumomab, Ibritumomab
Term
Which Mab is least likely to cause hypersensitivity rxn?
Definition
Human derived: Panitumumab
Term
Targeted therapy rash most associated w/ what drug?
Definition
Cetuximab (EGFR inhibitor)
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