Term
| In what ratio are T4 and T3 released from the thyroid? |
|
Definition
|
|
Term
| What enzyme converts T4 to T3? |
|
Definition
|
|
Term
| How are thyroid hormones transported in blood? |
|
Definition
Bound to Thyroxine Binding Globulin (TBG) for transport in blood
Hydrophobic |
|
|
Term
|
Definition
"Reverse" T3- the iodide closest to the amine group is cleaved off of T4 instead of the one furthest
Can be higher in pregnancy
Inactive |
|
|
Term
| Which is more active in tissues: T4 or T3? |
|
Definition
|
|
Term
| What is the underlying pathophys of Graves' disease? |
|
Definition
| Body secretes thyroid-stimulating antibodies |
|
|
Term
| If you have hyperthyroidism in the presence of increased TSH, where is the lesion likely to be? |
|
Definition
| Hypothalamus or anterior pituitary |
|
|
Term
| TSH levels in Hashimoto's? |
|
Definition
| Can go up or down- inflammation of thyroid triggers cell death --> cells release thyroid hormone when they die, negatively feeding back to hypothalamus to reduce TSH |
|
|
Term
| What hormone promotes calcium deposition in bone, secretion from intestines and kidneys? |
|
Definition
|
|
Term
| What 2 hormones promote release of Ca++ from bone and enhanced absorption from intestine/kidneys? |
|
Definition
|
|
Term
| What form of vit D is produced in the skin? |
|
Definition
7-dehydrocholesterol
Must be activated to cholecalciferol by UV light |
|
|
