Term
| what is lung bud derived from? what day of embryo? What separates it from it's origin? |
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Definition
| respiratory diverticulum from endoderm (foregut). day 22. Separated by Tracheo-Esophageal ridges. |
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Term
| laryngeal orifice function? |
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Definition
| embryological communication between respiratory primordium (lung bud) and pharynx. |
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Term
| Larynx derived from? which arches? |
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Definition
| Epithelium from Endoderm. Mesoderm gives muscles of larynx. Neural crest cells from 4th & 6th pharyngeal arches give cartilage. |
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Term
| Trachea. develop from what structure? what looks like in week 4? 3rd month? end of 3rd month? |
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Definition
| Straight portion of respiratory diverticulum. Week 4 - simple tube of endoderm surrounded by mesoderm. 3rd month - mesoderm give cartilage, muscle & CT. End of 3rd month - trachealis muscle, respiratory epithelium, cartilage plates. |
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Term
| Tracheo-esophageal fistula? |
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Definition
| result from incomplete division of foregut into esophageal & respiratory portions. |
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Term
| tracheo-esophageal fistula with atresia. what look like? what symptoms? Dx? |
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Definition
| upper esophagus ends abruptly. stomach fill w air. Gagging & cyanosis after eating. Reflux gastric contents into lungs. Dx - air in stomach. |
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Term
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Definition
| Vertebral Defect. Anal Atresia. cardiac defects. Tracheo-asophageal defects. Esophageal Atresia. Renal Abnormalities. limb defects. |
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Term
| which bronchus gets more things stuck in in? why? |
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Definition
| Right one. cuz descend more vertically. |
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Term
| primordium of broncho-pulmonary segments? |
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Definition
| each tertiary bronchus with it's surrounding mesenchyme. |
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Term
| origin of cartilage plates & smooth muscle around bronchi? |
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Definition
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Term
| visceral pleura derived from? parietal pleura? |
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Definition
| visceral - splanchnic mesoderm. parietal - somatic mesoderm. |
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Term
| Pseudoglandular Period. When? what does lung resemble? can baby breath air? |
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Definition
| 5 - 16 weeks. Resembles a compound exocrine gland. Terminal Bronchioles formed. NO respiration. |
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Term
| Canalicular Period. When? what 2 things develop? Can baby breath air? |
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Definition
| 16 - 25 weeks. respiratory bronchioles give rise to alveolur ducts. blood vessels from mesoderm surround bronchioles & terminal sacs. Baby can breath toward end of this period. |
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Term
| terminal sac period. when? what 2 things formed? what 2 cells formed? Time at which surfactant is made? |
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Definition
| 24 wks - term. primitive alveoli formed. epithelium thins & capillaries make contact. blood air barrier formed. Type 1 & 2 pneumocytes. Surfactant made at week 20 by type 2 pneumocytes. |
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Term
| alveolur period. when? what made? |
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Definition
| birth to 8 yrs. increase in # of bronchioles & alveoli. |
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Term
| how are the baby lungs cleared of fluid at birth. 3 routes? |
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Definition
| 1. thru nose & mouth by pressure on thorax during delivery. 2. into pulmonary capillaries. 3. into lymphatics & pulm arteries. |
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Term
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Definition
| risk of respiratory stress syndrome. prior to 26 wks high risk cuz lil surfactant made. Rx - mechanical breathing. Glucocorticoid - stimulate surfactant production & fetal lung development. |
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Term
| surfactant B deficiency disease |
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Definition
| auto recessive. fatal - respiratory failure. |
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Term
| unilateral pulmonary agenisis. symptoms? which lung assoc with more problems? |
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Definition
| bronchial bud fails to split. child develops respiratory distress w/ lower resp tract infection. assoc with other congenital deformities (more if agenisis of R lung) |
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Term
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Definition
| complete absence of lungs, bronchi, vasculature. fatal. |
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Term
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Definition
| inadequate size of resp components. |
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Term
| congenital bronchial cysts. cause? bronchi filled with what? Dx? |
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Definition
| abnormal dilation of bronchi. may be filled w fluid or air. honeycomb appearance on x-ray. |
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