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Eicosanoids
Pharmacology
26
Medical
Professional
02/04/2012

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Cards

Term
This releases arachidonic acid
Definition
phospholipase
Term
This generates PGH
Definition
COX
Term
This releases LTA's
Definition
5' Lipooxygenase
Term
This releases Thrombaxane
Definition
Cox--> PGH
Term
what are PGs inactivated by
Definition
dehydrogenation and/or reduction or non-enzymatic breakdown
Term
what are LT's inactivated by
Definition
peptidases
Term
effect of PGI on smooth muscle
Definition
increase in cAMP causing relaxation
Term
effect of TXA on smooth muscle
Definition
releases IP3 and Ca to cause contraction of smooth muscle
Term
PGI on platelets
Definition
vasodilation and INHIB of platelet aggregation
Term
PGI and E on gastric acid secretion
Definition
decreases
Term
PGI and E on pain threshold
Definition
lowers pain threshold
Term
LT4 on vessels and bronchioles
Definition
increase vascular permeability
constrict bronchioles
Term
These induce labor at any stage
Definition
PGE and PGF
Term
PGI on thrombosis
Definition
inhibits and dilates arterioles
Term
this maintains ductus arteriosus
Definition
PGE
Term
What can be used to close ductus arteriosus
Definition
COX inhibs
Term
this causes fever in the CNS
Definition
PGE
Term
large dose of PGI; physiological dose
Definition
pain; hyperalgesia
Term
These are inhibs of gastric acid secretion
Definition
PGI
Term
therapeutic abortifacients
Definition
dinoprostone and carboprose
Term
postpartum hemorrhage
Definition
carboprost
Term
dilation of ductus arteriosus
Definition
alprostadil (PGE analogue)
Term
when is Cox2 induced?
Definition
inflammation
Term
aspirin mech of action
Definition
irreversible inhib of Cox.

new enzyme must be synthesized
Term
5-lipoxygenase inhib used in asthma
Definition
zileuton
Term
LT recepeptor antag
Definition
zafirlukast
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