Term
|
Definition
| Cimetidine, Ranitidine, Famotidine, Nizatidine. MOA - reversible block of histamine H2 receptors. |
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|
Term
| H2 blocker use and toxicity |
|
Definition
| Use - peptic ulcer, gastritis, mild esophageal reflux. Toxicity (Cimetidine only) - potent inhibitor of P-450; it also has an antiandrogenic effect and decreased renal excretion of creatinine. |
|
|
Term
| proton pump inhibitors (2) |
|
Definition
|
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Term
|
Definition
MOA - irreversibly inhibit H+/K+ ATPase in stomach parietal cells.
Use - peptic ulcer, gastritis, esophageal reflux, Zollinger-Ellison syndrome. |
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Term
|
Definition
MOA - bind to ulcer base, providing physical protection, and allows HCO3- secretion to reestablish pH gradient in the mucous layer.
Use - to increase ulcer healing. |
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Term
|
Definition
MOA - a PGE1 analog. increased production and secretion of gastric mucous barrier.
Use - prevention of NSAID-induced peptic ulcers; maintenance of patent ductus arteriosus. also used to induce labor. |
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Term
|
Definition
| Toxicity - diarrhea, contraindicated in women of childbearing potential (abortifacient). |
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Term
|
Definition
MOA - a monoclonal Ab to TNF-alpha, proinflammatory cytokine.
Use - Crohn's disease, rheumatoid arthritis. |
|
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Term
|
Definition
| respiratory infection, fever, hypotension |
|
|
Term
| Sulfasalazine MOA and use |
|
Definition
MOA - a combination of sulfapyridine (antibacterial) and mesalamine (anti-inflammatory).
Use - ulcerative colitis, Crohn's disease |
|
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Term
|
Definition
| malaise, nausea, sulfonamide toxicity |
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Term
|
Definition
MOA - 5-HT3 antagonist. powerful central-acting antiemetic.
Use - control vomiting postoperatively and in patients undergoing chemotherapy. |
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Term
|
Definition
|
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Term
|
Definition
| can affect absorption, bioavailability, or urinary excretion of other drugs by altering gastric and urinary pH or by delaying gastric emptying |
|
|
Term
| Aluminum hydroxide (antacid) overuse |
|
Definition
| hypokalemia, constipation, hypophosphatemia |
|
|
Term
| Magnesium hydroxide (antacid) overuse |
|
Definition
|
|
Term
| Calcium carbonate (antacid) overuse |
|
Definition
| hypokalemia, hypercalcemia, rebound acid increase. |
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