Term
| First generation H1 blockers (3) |
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Definition
| diphenhydramine, dimenhydrinate, chlorpheniramine |
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Term
| Diphenhydramine, Dimenhydrinate, Chlorpheniramine use and toxicity |
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Definition
| Use - allergy, motion sickness, sleep aid. Toxicity - sedation, antimuscarinic, anti-alpha-adrenergic |
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Term
| Second generation H1 blockers (3) |
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Definition
| Loratadine, Fexofenadine, Desloratadine |
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Term
| Loratadine, Fexofenadine, Desloratadine use and toxicity |
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Definition
| Use - allergy. Toxicity - less sedation than 1st generation H1 blockers |
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Term
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Definition
| asthma use. a non-specific beta agonist. relaxes bronchial smooth muscle via beta 2 receptors. adverse effect is tachycardia (beta 1) |
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Term
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Definition
| asthma use. beta 2 agonist. relaxes bronchial smooth muscle (beta 2). use during acute exacerbation. |
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Term
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Definition
| asthma use. beta 2 agonist. long-acting agent for prophylaxis. Adverse effects are tremor and arrhythmia. |
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Term
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Definition
| asthma use. a methylxanthine. likely causes bronchodilation by inhibiting phosphodiesterase, thereby decreasing cAMP hydrolysis. Usage is limited because of narrow therapeutic index (cardiotoxicity, neurotoxicity). |
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Term
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Definition
| asthma use. a muscarinic antagonist. competitive block of muscarinic receptors, preventing bronchoconstriction. |
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Term
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Definition
| asthma use. prevents release of mediators from mast cells. effective only for the prophylaxis of asthma. not effectie during an acute asthmatic attack. toxicity is rare. |
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Term
| Beclomethasone, Prednisone |
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Definition
| asthma use. corticosteroids. inhibit the synthesis of virtually all cytokines. inactivate NF-kB, the transcription factor that induces the production of TNF-alpha, among other inflammatory agents. 1st line therapy for chronic asthma. |
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Term
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Definition
| asthma use. an antileukotriene. a 5-lipoxygenase pathway inhibitor. blocks conversion of arachidonic acid to leukotrienes. |
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Term
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Definition
| asthma use. antileukotrienes. block leukotriene receptors. |
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Term
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Definition
LTB - neutrophil chemotaxis.
LTC, LTD, LTE - bronchoconstriction, vasoconstriction, contraction of smooth muscle, increased vascular permeability. Zafirlukast and Montelukast block leukotriene receptors. |
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Term
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Definition
| (PGI) inhibit platelet aggregation, promote vasodilation, decrease in bronchial tone, decrease in uterine tone. |
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Term
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Definition
| (PGE, PGF) increase uterine tone, vasodilate, decrease bronchial tone. |
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Term
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Definition
| (TXA) increase platelet aggregation, increase vascular tone, increase bronchial tone. |
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