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Effector Mechanisms of Humoral Immunity
BBD Lec 4/7 @1PM
22
Medical
Professional
04/07/2010

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Cards

Term
what binds to Fc receptors (of macrophages)?
Definition
antibodies
Term
what happens when antibodies bind to Fc receptors?
Definition
antibody-mediated phagocytosis
Term
what is cross-linking?
Definition
several Fc receptors are bound by antibodies at the same time. Allows for phagocytosis.
Term
what are one of the most important Fc receptors to remember?
Definition
Fc-gamma RI. while one is inhibitory: Fc-gamma RII
Term
what is an "immune complex" ?
Definition
pathogen coated with antibodies
Term
great summary review on slide 14
Definition
describes how different immune cells react to immune complexes
Term
what is the form of IgM?
Definition
Pentamer.
Term
what is the main phagocytic antibody?
Definition
IgG
Term
what is the form of IgA?
Definition
dimer
Term
what is the function of IgM?
Definition
initiate complement cascade (since there is a short distance between the molecules)
Term
what are the 3 activation pathways of complement?
Definition
1) classical, 2) mannose-binding lectin, 3) alternative
Term
what does the classical pathway rely on?
Definition
antibodies.
Term
what is C1q? C3b?
Definition
Term
what is the first step in the lectin pathway?
Definition
binding of mannose-binding-lectin.
Term
what happens once the MBL binds to the bacterial surface?
Definition
proteases cleave C2a and C4b to then cleave C3 into C3a and C3b
Term
what is the alternative pathway?
Definition
spontaneous cleavage of C3
Term
what is common amongst all 3 pathways?
Definition
convertase cleaves C3 into C3b which is the major component in the complement pathway
Term
what is the membrane attack complex [also known as: MAC] . (PS: its at the end of the 3 different pathways) ?
Definition
C5b-9 is a pore that forms in the cell membrane
Term
what are Anaphylatoxins?
Definition
are fragments (C3a, C4a and C5a) that are produced as part of the activation of the complement system.
Term
what are some of the membrane complement regulatory proteins and what do they do?
Definition
keep us from killing our own cells. Some are: DAF, MCP, CR1, CD59. Found on cell surfaces. Accelerate degradation of the convertases in the 3 pathways.
Term
what happens when C3b attaches to a host cell?
Definition
factors H and I attach and deactivate it.
Term
what happens when C3b attaches to a bacterial cell?
Definition
Factors H and I do not recognize it and it becomes activated.
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