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Dyslipidemia Niacin
Dyslipidemia Niacin
11
Pharmacology
Professional
09/12/2012

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Cards

Term
How niacin work?
Definition

Inhibits VLDL production (which decreases LDL and decreases TGs) and decreases the removal of HDL (causing increase in HDL)

Term
Brand name for extended release Niacin?
Definition
Niaspan
Term
Dosing for extended rlease niacin?
Definition

500 QHS x 4 weeks

1000 QHS x 4 weeks

Can increase to 1500 - 2000 QHS

Max: 2 grams daily

Term
The problem with Niacin is?
Definition
tolerability due to flushing/itching
Term
Is Niaspan the most economical choice?
Definition

No. It is the most expensive. But it's the best clinical choice because it has decreased side effects withouth increased risk liver damage

Term
Niaspan is approved for use with what two statins?
Definition
simvastatin and lovastatin
Term
Are Niaspan tablets interchangeable?
Definition

NO. Niaspan talbets are not interchangeable from other formulations; also the 500 and 750 mg tabs are not interchangeable

 

3 of the 500 mg tabs ≠ 2 of 750 mg tabs

Term
Major side effect of Niacin?
Definition
Flushing and pruritis (itching)
Term
How should Niaspan be taken?
Definition

At night after a low-fat snack. Other niacins: take with food

Term
How to do deal with the flushing side effect?
Definition

pre-treat with 325mg uncoated aspirin (or ibuprofen) 30 min before dose (for a few weeks) to decrease flushing. With Niaspan, flushing will occur mostly at night

Term
[image]
Definition
Statement. Not a question.
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