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Dyslipidemia Fibrate
Dyslipidemia Fibrate
10
Pharmacology
Professional
09/12/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
How do fibrates work?
Definition

By activating PPARα, there is enhanced elimination and decreased synthesis of VLDL (causing decreased TGs) and will increase HDL

 

Term
What can happe when reducing TGs?
Definition

When TGs are high, reducing TGs can increase LDL - be careful to monitor LDL when reducing TGs

Term
Brand name for Fenofibrate?
Definition
TriCor
Term
Does TriCor come in different strenghts?
Definition

Yes. And the delivery technology may be different. If you want to dispense a generic, may need to call prescriber for a cloes mg strength - and try to match one with a similar delivery technology, using the oragne book

Term
Dosage form of fibrates?
Definition

Micronized formulations and other modes are used to improve bioavailability - to get a higher TG reduction (which are dose dependent)

Term
[image]
Definition
Statement. Not a question.
Term

When used in combination with statins, fenofibrates have less risk of myopathies (and rhabdomyolysis) than gemfibrozil.

Definition
Statement. Not a question.
Term
Fibrates should be taken once daily, with or without food, for all except?
Definition
Lofibra and Lopid
Term
Lofibra should be taken?
Definition
once daily, with food
Term
Lopid should be taken?
Definition
twice daily, 30 minutes before breakfast and dinner
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