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Dunaway Lecture 1
Overview of Lecture 1 Learning Objectives for Dunaway
10
Pharmacology
Professional
09/21/2012

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Term
3 alleles --> extensive metabolizers
6 alleles --> intermediate metabolizers
11 alleles --> poor metabolizers
Definition
CYP2D6 (enzyme that possesses genetic variants affecting drug metabolism)
Term
Allele 1 = normal phenotype
Alleles2 and 3 = poor metabolizers
Definition
Cyp2C19 (enzyme that possesses genetic variants affecting drug metabolism)
Term
No gene expression or dysfunctional protein
Definition
DNA fragment deletions or insertions into genes (altered gene DNA sequence)
Term
If inserted intact, increased gene expression and protein levels; If not inserted intact --> DNA fragment insertion
Definition
Gene duplication or increased copy number of genes (altered gene DNA sequence)
Term
most common cause of gene sequence variation; SNP --> phenotypic change and can increase risk of disease; most SNP's occur in introns and rarely cause phenotypic disease
Definition
Single Nucelotide Polymorphism (Altered Gene DNA sequence)
Term
Hepatic enzyme that conjugates glucuronic acid to bilirubin to increase solubilityand elimination
Definition
UDP-glucuronosyltransferase 1A1 (UGT1A1)
Term
Gilbert disease
Definition
genetic variant UGT1A1*18
(poor/slow metabolizer of irinotecan --> increase drug levels)
Term
labs will show drug levels in normal therapeuic range
Definition
alteration of drug pharmacodynamics i.e. how patient responds
Term
labs will show non-therapeutic circulating levels of drug and/or active metabolites
Definition
Abnormal Drug Pharmacokinetics
Term
Mechanisms of management strategies that are used to alter the pathophysiological symptoms
Definition
Replacement therapy for hormone deficiencies; use of hormones or hormone analogs as pharmacological agents; utilization of agents to antagonize the ADR's of hormone action
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