Shared Flashcard Set

Details

Drugs
Drugs covered in immunopharmacology
32
Other
Not Applicable
10/21/2012

Additional Other Flashcards

 


 

Cards

Term
Corticosteroids
Definition
modifies gene expression; affects all immune cells; suppresses many proteins
Term
Azathioprine
Definition
inhibits an enzyme required for the synetheisis of purines (adenine and guanine)
Term
Methotrexate
Definition
inhibits purine and thymidine synthesis through inhibiting enzymes
Term
Mycophenolate
Definition
Inhibits DNA syntehsis by blocking de novo guanine synthesis
Term
Cyclophosphamide
Definition
alkylating agent- prevents DNA replication and protein production (more potent)
Term
Chlorambucil
Definition
alkylating agent- prevents DNA replication and protein production (less potent)
Term
Cyclosporin A (CSA)
Definition
works by inhibiting t cell activation by blocking IL-2 production
Term
Tacrolimus
Definition
inhibits calcineurin activation, blocking IL-2 production
Term
Sirolimus
Definition
In T cells blocks signals from IL-2 receptor-- inhibits a protein called mTOR
Term
Muromonab
Definition
mouse mAb works to destroy t cells, Ab recognizes CD3 and causes t cells to be opsonized
Term
Antithymocyte globulin
Definition
(horse);recognize many antigens; antibodies opsonize, fixing complement, ADCC
Term
Thymoglobulin
Definition
(rabbit); recognize many antigens; antibodies opsonize, fixing complement, ADCC
Term
Basiliximab (simulect)
Definition
chimeric mAb; blocks IL2 binding to the IL2 receptor- more likely to affect t cells that are activated against graft antigens
Term
Etanerecept (Enbrel)
Definition
Form soluble receptors/fusion proteins; blocks normal function of TNF alpha
Term
Infliximab (Remicade)
Definition
Chimeric mAb; binding TNF alpha to block it from binding to its receptor
Term
Adalimumab (Humira)
Definition
Human mAb; binding TNF alpha to block it from binding to its receptor
Term
Certolizumab pegol (Cimzia)
Definition
pegylated humanized fab to TNF alpha; Fab fragment is able to block TNF alpha
Term
Anakinra (Kinaret)
Definition
Recombinant form of a naturally occuring IL-1 receptor antagonist; binds to IL-1 receptor on target cells to keep IL-1 from binding
Term
Toclizumab (Actemra)
Definition
Humanized mAb; binds IL-6 receptor to keep IL-6 from binding
Term
Abatacept (Orencia)
Definition
Soluble receptor/fusion protein; blocks B7---CD28 interaction by binding to B7
Term
Alefacept (Amevive)
Definition
Soluble receptor/fusion molecule; blocks t cell activation by blocking adhesion between t cell and APC
Term
Natalizumab (tysabri)
Definition
humanized mAb; block adhesion molecule on t cells that helps them move into brain and intestine
Term
Fingolimod (Gilenya)
Definition
Fungal metabolite; holding lymphocytes in the lymph nodes to keep them from entering blood and reaching the brain
Term
Rituximab (Rituxan)
Definition
chimeric mAb; kill b cells that make antibodies that form complexes and cause type III hypersensitivity; binds CD20
Term
Omalizumab (Xolair)
Definition
humanized mAb; binds to IgE and blocks it from binding to the Fc receptor present on mast cells, eosinophils
Term
INF Beta
Definition
type 1 interferon; shuts off TH1 type immune responses and production of inflammatory cytokines; MOA not understood
Term
Homologous pooled human antibody
Definition
fix complement, activate ADCC, block, opsonize (remove IgE, not meant to activate allergies), all the normal functions of antibodies
Term
Homologous human hyper-immunoglobuline
Definition
Antibodies are collected from specific people with high levels of antibodies against the pathogen or antigen of interest
Term
Rhogam
Definition
Drug binds to D antigen on fetal RBCs to block mother from generating an immune response (prevent "hemolytic disease of the newborn")
Term
Heterologous hyper-immune serum
Definition
Collected from animals immunized with a specific antigen. Often its a toxin or a venom; blocks/neutralizes
Term
Palivizumab (Synagis)
Definition
Humanized mAb; recognizes respiratory syncytial virus (RSV), no RSV vaccination- usually occurs in children (provides passive immunity)
Term
Alum
Definition
adjuvant used in human vaccines; aluminum salt suspended in gel
Supporting users have an ad free experience!