Term
| What would you use to treat M. Tuberculosis? |
|
Definition
Prophyalxis: Isoniazid
Treatment: RIPE-->
Rifampin
Isoniazid
Pyrazinamide
Ethanbutol |
|
|
Term
| What woud you use to treat M. avium-intracellulare? |
|
Definition
Prophylaxis: Azithromycin
Treatment: (ARSE)
Azithromycin
Rifampin
Streptomycin
Ethambutol
|
|
|
Term
| What would you use to treat M. Leprae? |
|
Definition
Dapsone
Rifampin
Clofazimine |
|
|
Term
| What are the anti-TB drugs? |
|
Definition
INH-SPIRE
Isoniazid (INH)
Streptomycin
Pyrazinamide
Rifampin
Ethambutol |
|
|
Term
What is a key side effect of ethambutol that you need to know?
What is its MOA? |
|
Definition
- Optic neuropathy (red-gleen blindness)
- Decreases carbohydrate polymerization of mycobacterium wall by blocking arabinosyltransferase
|
|
|
Term
| What is a general toxicity of anti-TB drugs? |
|
Definition
|
|
Term
| What is the MOA of Isoniazid (INH)? |
|
Definition
- Dec synthesis of mycolic acids
- Bacteria catalase peroxidase needed to convert INH to active metabolite
|
|
|
Term
| What do you use Isoniazid (INH) for? |
|
Definition
Mycobacterium tuberculosis
Only agent used as solo prophylaxis against TB |
|
|
Term
| What is the toxicity of Isoniazid? |
|
Definition
- Neurotoxicity
- Hepatotoxicity
- Lupus
- Pyridoxine (vitamin B6) can prevent neurotoxicity and lupus
- "INH Injures Neurons and Hepatocytes"
|
|
|
Term
| What is the MOA of Rifampin? |
|
Definition
| Inhibits DNA-dependent RNA polymerase |
|
|
Term
| What do you use rifampin for? |
|
Definition
- Mycobacterium tuberculosis
- Delays resistance to dapsone when used for leprosy
- Used for menigococcal prophylaxis & chemoprophylaxis in contacts of children w/ H. influenzae type B
|
|
|
Term
| What is the toxicity of rifampin? |
|
Definition
Rifampin's 4 R's:
- RNA polymerase inhibitor
- Revs up microsomal P-450
- Red/orange body fluids
- Rapid resistance if used alone
|
|
|
Term
| What is the drug of choice for a meningococcal infection? |
|
Definition
|
|
Term
| What would you use for nonsurgical prophylaxis for pts w/ gonorrhea? |
|
Definition
|
|
Term
| What would you do for prophylaxis nonsurgical treatment for pts w/ syphilis? |
|
Definition
|
|
Term
| What would you do for prophylactic treatment of a patient with recurrent UTIs? |
|
Definition
TMP-SMX
(Trimethoprim, sulfa drugs)
Remember, nucleic acid synthesis inhibitors by blocking folic acid |
|
|
Term
| What would you do to prophylactically treat a patient with pneumocystis jiroveci pneumonia? |
|
Definition
TMP-SMX (drug of choice)
aerosolized pentamidine |
|
|
Term
| What drug would you use for prophylaxis for pts w/ endocarditis from surgical or dental procedures? |
|
Definition
|
|
Term
| What would you use to treat MRSA? |
|
Definition
|
|
Term
| What would you use to treat VRSA, VRE? |
|
Definition
| Linezolid, streptogramins (quinupristin/dalfopristin) |
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