Term
|
Definition
| disorder that is characterized by destructive pattern of using substance that leads to significant problems or distress |
|
|
Term
|
Definition
| A disease that is destructive pattern of drug abuse that leads to significant problems involving dependence. A DISEASE DAMMIT |
|
|
Term
|
Definition
| physical need for a specific agent that results in withdrawal when the agent is taken away |
|
|
Term
|
Definition
psychoactive, disinhibition, enhanced sensory perception, affect coordination memory pain
pain relieving, controls nausea, appetite stimulant, decrease ocular pressure
NO TOLERANCE |
|
|
Term
|
Definition
inhaled - rapid access to brain cross BBB
oral - 30-90 minutes
effects dose dependent lipid soluble
blood test for 3-10 days |
|
|
Term
|
Definition
| cannabinoid receptors - GPCR CB1 and CB2 |
|
|
Term
|
Definition
morphine like properties.
analgesia, miosis, respiratory depression, nausea & vomiting
cough depression, gastric depression |
|
|
Term
| morphine Pharmacokinetics |
|
Definition
IV readily absorbed
metabolized in liver to make active and inactive stuff
low lipid solubility |
|
|
Term
|
Definition
mu (most pain relief), delta, k
located in CNS and periphery
60% homology among receptor subtypes |
|
|
Term
|
Definition
Coma
pinpoint pupils
respiratory depression |
|
|
Term
|
Definition
Naloxone
antagonist
works in seconds |
|
|
Term
|
Definition
Methadone
synthetic opioid
half life 15-40 hours
controlled withdrawal |
|
|
Term
| buprenorphine/naloxone(suboxone) |
|
Definition
buprenorphine - partial agonist
naloxone - full antagonist
decreased potential for abuse
fewer withdrawal symptoms |
|
|
Term
|
Definition
stimulate CNS
blocks reuptake of serotonin, dopamine, NE
metabolized in liver |
|
|
Term
|
Definition
| Hallucinogenic, odorless, tasteless, pupil dilation, reduce appetite, wakefulness |
|
|
Term
|
Definition
completely absorbed after oral ingestion
stimulation peaks at 2 hours
goes to all organs BBB
almost completely metabolized |
|
|
Term
|
Definition
inhibits activation of serotonin receptors
tolerance buildup is rapid and reversible |
|
|
Term
|
Definition
psychostimulant
potent neurotoxin
prolonged post-withdrawal syndrome
increase alertness, concentration, energy.
causes dopamine release, blocks dopamine reuptake |
|
|
Term
|
Definition
| stimulant and psychodelic, increased energy, euphoria, will permanantly damage serotonin neurons |
|
|
