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Drugs in Lung Cancer Management
Drugs mentioned in lecture one
16
Other
Not Applicable
12/06/2012

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Cards

Term
Cisplatin
Definition
highly emetogenic, ototoxic, and renal toxic Platinum Agent
Term
Carboplatin
Definition
highly emetogenic and renal toxic Platinum Agent (use calvert formula dosing)
Term
Oxaliplatin
Definition
Platinum agent not used in lung cancer, mostly in colon
Term
Paclitaxel
Definition
Taxane agent, moderate to low emetogenic potential, can be neurotoxic
Term
Docetaxel
Definition
Taxane agent that is better tolerated than Paclitaxel
Term
Etoposide
Definition
Mildly emetogenic, severe hypotension with rapid infusion
Term
Vinblastine and Vinorelbine
Definition
Neurotoxic, vinca alkaloid-- *fatal if administered intrathecally!!
Term
Erlotinib
Definition
Tyrosine kinase inhibitor: Improves OS by 3.3 months, 2nd or 3rd line
Term
Crizotinib
Definition
Tyrosine kinase inhibitor: Used to terat NSCLC that is advanced or metastasis and is caused by a defect in gene called ALK
Term
Bevaczimuab
Definition
used in combo with chemo as first line therapy in advanced NSCLC
Term
Gemcitabine
Definition
one of the agents that can be used in combo with Cisplatin or Carboplatin in 1st line therapy in advanced NSCLC
Term
Irinotecan
Definition
one of the agents that can be used in combo with Cisplatin or Carboplatin in 1st line therapy in advanced NSCLC
Term
Pemetrexed
Definition
an agent that can be used as second line therapy in advanced NSCLC
Term
Cisplatin/irinotecan
Definition
Data encouraging for extensive stage disease in SCLC but needs to be confirmed in US studies
Term
Cisplatin with pemetrexed
Definition
treatment in Mesothelioma
Term
Folic acid, Vitamin B12, Dexamethasone
Definition
Adjuvant meds necessary for pemetrexed
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