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Drugs Gastrointestinal chaps 47 48
Pharm
40
Pharmacology
Undergraduate 4
09/22/2016

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Term
Nonprescription Anti emetics
Definition
Anti histamines, Bismuth subsalicylate, Emetrol
Term
Anti Histamines
Definition
Drugs: dimenhydrinate, meclizine hydrochloride

Action: inhibit vestibular stimulation in the middle ear

Symptoms:anticholinergic (drowsiness, dry mouth, blurred vision caused by pupillary dilation, tachycardia (with anticholinergic use), urinary retention, and constipation

These drugs should not be used by patients with glaucoma.
Term
Bismuth subsalicylate (Pepto-Bismol)
Definition
Action: acts directly on gastric mucosa to decrease irritation, also antibacterial
Term
Emetrol
Definition
Action: decreases n/v by changing the gastric pH, decreases smooth muscle contraction of the stomach

High sugar content, avoid with diabetes patients
Term
Prescription Anti emetics
Definition
Dopamine antagonists, Phenothiazines, Benzodiazepines, 5-HT3 receptor antagonists.
Term
Dopamine Antagonists
Definition
Butyrohenones: Droperidol, Haloperidol

Action:Block dopamine 2 receptors in the CTZ

Side effects: EPS symptoms, hypotension

May be used for post op nausea and vomiting.
Term
Phenothiazines
Definition
Drugs: Promethazine

Also an antihistamine

Side effects antihistamine and anticholinergic effects
Term
Benzodiazephines
Definition
Drug: lorazepam

action:Used for its antianxiety properties, used in combination with others for chemotherapy .
Term
Nonprescription Anti emetics
Definition
Anti histamines, Bismuth subsalicylate, Emetrol
Term
Anti Histamines
Definition
Drugs: dimenhydrinate, meclizine hydrochloride

Action: inhibit vestibular stimulation in the middle ear

Symptoms:anticholinergic (drowsiness, dry mouth, blurred vision caused by pupillary dilation, tachycardia (with anticholinergic use), urinary retention, and constipation

These drugs should not be used by patients with glaucoma.
Term
Bismuth subsalicylate (Pepto-Bismol)
Definition
Action: acts directly on gastric mucosa to decrease irritation, also antibacterial
Term
Emetrol
Definition
Action: decreases n/v by changing the gastric pH, decreases smooth muscle contraction of the stomach

High sugar content, avoid with diabetes patients
Term
Prescription Anti emetics
Definition
Dopamine antagonists, Phenothiazines, Benzodiazepines, 5-HT3 receptor antagonists.
Term
Dopamine Antagonists
Definition
Butyrohenones: Droperidol, Haloperidol

Action:Block dopamine 2 receptors in the CTZ

Side effects: EPS symptoms, hypotension

May be used for post op nausea and vomiting.
Term
Phenothiazines
Definition
Drugs: Promethazine

Also an antihistamine

Side effects antihistamine and anticholinergic effects
Term
Benzodiazephines
Definition
Drug: lorazepam

action:Used for its antianxiety properties, used in combination with others for chemotherapy .
Term
5-HT3 receptor antagonists
Definition
Action: Blocks serotonin receptors in CTZ

Drugs: Ondanetron
Increased efficacy with steroids; potentially fatal cardiac arrhythmia with IV route.

Palonosetron:2nd gneration more potent, longer half life
Term
Glucocorticoids
Definition
Drugs: dexamethasone, methylprednisolone

Use: cancer chemotherapy, given IV only for a short time
Term
Cannabonioids
Definition
Drugs: dronabinol, used when cannot take other antiemetics, avoid giving to patients with psychiatric disorders, can stimulate appetite for AIDS patients.
Term
Miscellaneous drugs
Definition
Metroclopramide- interacting with receptors for ach and dopamine on the gastrointestinal muscles and nerves, used to increase gastric emptying.
Blackboxwarning- tardice dyskinesia.
Term
Prescriptive antihistamines and anticholinergics
Definition
Drugs: Hydroxyzine, Promethazine, Scolamine

Side effects: drowsiness, dry mouth, blurred vison caused by pupillary dialation, tachycardia(with anticholonergic use) and constipation

Should not be used with patients with glaucoma.
Term
Emetics
Definition
Drug: Ipecac

Action: stimulates the CTZ and acts directly on gastric mucosa

Use Induces vomitting after toxic substance, onset of 15-30 minutes.

Caution: avoid vomiting if substance is caustic or petroleum because can damage Esophagus on the way back up.
Activated charcoal is given when emesis is contraindicated.
Term
Antidiarrheal 3 categories
Definition
Absorbents, Opioids, Somatastatin analogs.
Term
Absorbents
Definition
Drugs Bismuth-subsalicylate, Kaolin, Questran.

Action: coats GI tract, absorbs bacteria or toxins.
Term
Opioids
Definition
Drugs: Lomotil(sechedule 5 controlled substance), Loperamide(OTC)

Action: Rapid onset and effectiveness. At doses used for diarrhea, opioids do not produce dependence or serious adverse effects.
Term
Somatostatin analogs
Definition
Drugs: octreotide
Used for severe diarrhea from cancer
Action: inhibits gastric acid, secretions, and hormones. Decreases smoothmuscle contractillity.
Term
Nursing interventions for N/V
Definition
*nonpharacological interventions
*stay ahead of it, take it prophylactically
*monitor vital signs, bowel sounds
*monitor for dehydration
*warn cilent to not take alcohol with antiemetics
*Avoid giving to pregnant women
*Avoid driving
Term
Nursing interventions for anti diarrheals
Definition
*Monitor BP and respirations
*report more than 10 to 15 mm HG decrease in BP
*Monitor bowel movements and sounds
*Monitor electrolytes
*If diarrhea persists after 48 hours, notify healthcare provider.
Term
Treatment for constipation
Definition
Laxatives- drugs that promote bowel movement
Cathartic- drug thatpromotes strong and complete dowel emptying
Purgatives- promotes watery stoll with cramping(harsh)
Term
Bulk forming
Definition
Drug: Metamucil

*Absorbs water- add t the size of the fecal mass
*Prevention and treatment of chronic constipation.
*Slow onset of action
*Not used when a rapid and complete bowel evacuation is necessary
*administration: mix in glass of water or juice. stir and drink immediately followed by one glass of water.
Term
Stool softeners
Definition
Drugs: Colace, Amitiza(Cl channel activator)

*Cause more water and fat to be absorbed into the stools
*emulsifies and lubricates the feces
*used to prevent constipation
Term
Stimulant laxatives
Definition
Drugs: Ex-Lax, Dulcolax, Correctol

*Promote parastalsis by irritating the bowel
*more likely to cause diarrhea and cramping
*should only be used occasionally- may cause dependence and depletion of fluid and electrolytes
Term
Osmotic Laxatives
Definition
Drugs: Milk of magnesia, polyethlene glycol

*Cause water to be retained in the fecal mass to cause more watery stool
*Used for surgical and diagnostic prep
*Side effects: Fluid and electrolyte imbalances, hypotension, weakness
Term
Contraindications of Laxatives
Definition
*undiagnosed abdominal pain
*inflammatory disorders of the GI tract: Appendicitis, diverticulitis, UC
*Spastic colon
*Bowel obstruction
Term
Teachings for laxatives
Definition
*alternatives: high fiber diet, increased fluid
*stool softeners and bulk products preferable to stimulants
*laxative dependency
Term
Reflux
Definition
occurs when stomach contents backup through the LES into the esophagus
Term
GERD
Definition
Gastroesophageal Reflux Disease
Term
Peptic Ulcer Disease
Definition
*Ulcers in the stomach or intestine
*single small round cavities; breakdown of mucosa
*Caused by helicobacter pylori organism, some are due to medications few by stomach or intestinal cancers.
Term
Drug treatment for Peptic ulcer disease
Definition
*H2- receptor blockers
*Antibiotics
*Proton pump inhibitors
*Antacids
Term
Histamine-2 (H2) Receptor Antagonists
Definition
Drugs: Zantac, Pepcid

*Prevents histamine from stimulating the H2 receptors on gastric parietal cells, reducing volume and concentration of gastric acid secretions.
*Adverse effects are minor.
*wait 30mins to an hour between taking antacid and H2 blocker
*Zantac should not be taken with antacids, interacts with other meds and labs.
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