Term
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Definition
coricosteroids, calcineurin inhibitors, mTOR, cytoxoxic agents |
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Term
used to prevent rejection of grafted tissue |
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Definition
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Term
side effects of corticosteroids |
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Definition
adrenal insufficiency, osteoproosis, increased risk of infection, muscle wastin, thin skin, fluid and electorlyt imbalances, glucose intolerance, psychologic disturbances, peptic ulcer disease |
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Term
corticosteroids nursing interventions |
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Definition
doses must be tapered off when discontinued to prevent acute adrenal insufficienct, protect patient form sources of infection, protect fragile skin from trauma |
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Term
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Definition
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Term
used to rpeved rejection of transplanted tissue by reducint proliferation of B cells and cytotoxic T cells |
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Definition
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Term
side effects of calcineruin inhibitors (CI) |
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Definition
nephrotoxicity, infection, hepatotoxicity, lymphoma, hypertension, anaphylaxis with IV route |
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Term
_ inhibits metabolism, raising CI blood level |
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Definition
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Term
oral solutions of CI can be mixed with |
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Definition
milk, apple or orange juice |
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Term
advise the pt taking calcineurin inhibitors the importance of regular |
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Definition
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Term
mTOR (mammalian target of rapamycin) inhibitors |
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Definition
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Term
suppresses proliferation of B cells and T cells |
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Definition
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Term
used to prevent rejection of transplanted kidneys |
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Definition
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Term
side effects of mTOR inhibitors |
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Definition
risk fo infection, elevated serum lipids, rash, acne, anemia, thrombocytopenia, joint pain, diarrhea, hypokalemia, sever complications in liver and lung receipients, thrombosis in transplanted kindey |
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Term
everolimus can also cause |
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Definition
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Term
mTOR should be taken with |
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Definition
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Term
grapefruit juice raises serum drug levels of |
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Definition
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Term
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Definition
cyclophosphamide, azathioprine, mycophenylate mofetil |
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Term
prevents rejection of transnplanted tissue by killing B and T lymphocytes |
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Definition
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Term
side effects of cytotoxic agents |
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Definition
bone marrow supression, neutropenia, thrombocytopenia, infection, GI disturbances, hair loss, reduced fertility, increased risk of malignancy |
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Term
nursing interventions for nursing interventions |
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Definition
stress importance of regular blood studies, protect patients from sources of infection |
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Term
folate antagonists/antimetabolic |
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Definition
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Term
supresses B and T lymphocyte production, by interfering with folate metabolism |
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Definition
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Term
methotrexate is used to treat |
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Definition
psoriasis, arthritis, various types of cancer, acute lymphoblastic leukemia, CNS prophylaxis with leukemia therpay, prevention of graft versus host disease after transplant |
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Term
side effects of folate antagonist |
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Definition
liver damage, dosage for cancer treatment can cause nausea, vomiting, rash, diarrhea, leukopenia, anemia, thrombocytopenia, headache, confusion, hair loss |
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Term
nursing interventinos for mthotrexate |
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Definition
protect form infection, stress need for regular blood tests, inspect skin for serious rash, sore throat, fever, bleeding |
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Term
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Definition
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Term
affects the biosnthesis of DNA and RNA |
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Definition
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Term
cytarabine is used to treate |
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Definition
AML, ALL, non-hodgkin lymphoma |
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Term
side effect of pyrimidine analog |
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Definition
neutropenia, anemia, thrombocytopenia,anusea and vomiting, fever, stomatitis, liver damage, headache, conjucntivitis, pulmonary edema, cerbellar toxicity |
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Term
nursing interventions for cytarabine |
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Definition
monitor for excessive bruising, prolonged bleeding, avoid exposure to infections, teach good hygiene |
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Term
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Definition
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Term
destroys target cells by inhibiting DNA and preventing DN repari |
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Definition
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Term
antrachylenes are used to treat |
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Definition
hodgkin and non hodgkn lymphoma, aml and ALL, and other cancers |
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Term
side effects of anthracyclines |
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Definition
neutropenia, anemia, thrombocytopenia, cardiotoxicity, nausea and vomiting, hair loss, stomatitis, anorexia, conjunctivitis |
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Term
nursing interventions for anthracyclines |
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Definition
inform patient that the drug will turn urin and sweat red and that extremitis may become pigmented, IV route only |
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Term
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Definition
belimumab, rituximab, basilizimab, lymphocyte immune globulin |
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Term
used only to prevent rejection of kidney allogract and to treat systemic lupus erythematosus |
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Definition
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Term
lymphocyte immune globulin is used for |
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Definition
renal transplants and aplastic anemia |
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Term
other monoclonal antibodies are used to treat |
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Definition
non-hodgkin lymphoma, systemic lupus erythematosus, some luekimas (ALL) |
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Term
TYROSINE KINASE INHIBITORS |
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Definition
imatinib, nilotinib, dasatinib |
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Term
inhibits proliferation and promotes death of cancer cells |
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Definition
tyrosine kinase inhibitors |
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Term
tryosine kinase inhibitors treat |
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Definition
chronic myelogenous leukemia, some GI tumors |
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Term
side effects of tyrosine kinase inhibitors |
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Definition
neutropenia, anemia, thrombocytopenia, nausea, diarrhea or constibation, myalgia, rash, edema, liver, injury, fluid retention, pulmonary edema, cardiac dysrhythmias |
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Term
nursing interventions for tyrosine kinase inhibitors |
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Definition
monitor resp status, reprot dyspnea, dedema, bleeding,infspect skin, stress to patient importance of blood tests, asses peripheral and apical pulses for irregularity,, take same time each day |
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